Abstract: The present invention provides a compound represented by formula I, a racemate, an enantiomer, a diastereoisomer and a pharmaceutically acceptable salt thereof, and their use in preventing or treating a related disease caused by coronavirus and/or picornavirus infection.

Abstract: Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis.

Abstract: Provided herein is a solid dispersion, which comprises a carrier and an active ingredient. The active ingredient is one or more of the compound shown in formula (I) (APG-115), its pharmaceutically acceptable salt, its crystal form and its hydrate. The solid dispersion can improve the dissolution of the active ingredient APG-115. The dissolution of APG-115 of some solid dispersions can reach more than 90%, and has good stability. It can improve the dissolution and dissolution of drugs in gastrointestinal fluid, so as to improve the oral bioavailability. The solid dispersion shows high plasma exposure in animals, that is, higher drug peak concentration and higher area under blood concentration curve.

Abstract: A lifting device for building a steel structure hoistway and a method for building a steel structure hoistway. The lifting device includes a lifting mechanism and a crane mechanism. The lifting mechanism includes a bottom platform, a middle platform and a top platform. The crane mechanism is arranged on the top platform of the lifting mechanism, and includes a base and a crane on the base. The base is arranged on the top platform and is rotatable relative to the top platform along a vertical axis, and the hanger frame of the crane is movable between a vertical orientation and an inclined orientation. The lifting mechanism is configured to ascend and descend in the constructed steel structure hoistway, and the crane mechanism is configured to lift building materials, such as steel beams, steel columns, etc., for use in building the steel structure hoistway to their designed installation locations.

Abstract: A lifting device for building a steel structure hoistway and a method for building a steel structure hoistway. The lifting device includes a lifting mechanism and a crane mechanism. The lifting mechanism includes a bottom platform, a middle platform and a top platform. The crane mechanism is arranged on the top platform of the lifting mechanism, and includes a base and a crane on the base. The base is arranged on the top platform and is rotatable relative to the top platform along a vertical axis, and the hanger frame of the crane is movable between a vertical orientation and an inclined orientation. The lifting mechanism is configured to ascend and descend in the constructed steel structure hoistway, and the crane mechanism is configured to lift building materials, such as steel beams, steel columns, etc., for use in building the steel structure hoistway to their designed installation locations.

Abstract: The invention discloses a solid dispersion, a pharmaceutical preparation, a preparation method and an application thereof. The solid dispersion of the invention comprises carriers and active constituents, which is a compound as shown in formula (I) and/or a pharmaceutically acceptable salt thereof; The carrier is “homopolymer and copolymer of N-vinyl lactam” and/or pH-dependent cellulose derivatives. The preparation of the invention comprises the solid dispersion, fillers and disintegrating agents. The solid dispersion of the invention has good dissolution and significantly improves the solubility of effective constituents. The preparation can effectively improve the bioavailability of Bcl-2 inhibitor, has good dissolution and stability, and can improve the safety of a medication.

Abstract: Provided herein is a solid dispersion, which comprises a carrier and an active ingredient. The active ingredient is one or more of the compound shown in formula (I) (APG-115), its pharmaceutically acceptable salt, its crystal form and its hydrate. The solid dispersion can improve the dissolution of the active ingredient APG-115. The dissolution of APG-115 of some solid dispersions can reach more than 90%, and has good stability. It can improve the dissolution and dissolution of drugs in gastrointestinal fluid, so as to improve the oral bioavailability. The solid dispersion shows high plasma exposure in animals, that is, higher drug peak concentration and higher area under blood concentration curve.

Abstract: A handrail safety control device, a transportation system and a handrail safety control method. The handrail safety control device is provided for a transportation system having a handrail, the handrail including a body and a handrail belt, the handrail belt being driven under power to move relative to the body and forming an engaged state or a disengaged state with the body. The handrail safety control device includes: a contact portion disposed in a preset section of the handrail, the contact portion being in a first state or a second state respectively when the handrail belt in the preset section is in the engaged state or the disengaged state, wherein in the first state, the contact portion is in contact with the handrail belt, and in the second state, the contact portion is at least partially out of contact with the handrail belt; and a signal generation portion.

Abstract: A handrail safety control device, a transportation system and a handrail safety control method. The handrail safety control device is provided for a transportation system having a handrail, the handrail including a body and a handrail belt, the handrail belt being driven under power to move relative to the body and forming an engaged state or a disengaged state with the body. The handrail safety control device includes: a contact portion disposed in a preset section of the handrail, the contact portion being in a first state or a second state respectively when the handrail belt in the preset section is in the engaged state or the disengaged state, wherein in the first state, the contact portion is in contact with the handrail belt, and in the second state, the contact portion is at least partially out of contact with the handrail belt; and a signal generation portion.

Abstract: Systems and methods are provided herein for establishing data constructs necessary for efficient and transparent tiering of data from local storage to cloud storage, and there use in transferring data to and from cloud storage. Files data can split into chunks and stored as individual objects in cloud storage. A stub file can replace the local file in local storage and describe a mapping of cloud objects that contain data to specific regions of the file. Upon creation of the stub and transfer of data to cloud storage, local storage capacity previously dedicated to file data can be freed for other uses.

Abstract: Systems and methods are provided herein for writing back data to files tiered in cloud storage. Files tiered to cloud storage can be stored in chunks where each chunk is stored as a distinct cloud object and where each cloud object is mapped to known offset regions of a file and the mapping is stored in local storage within a stub file. If the file is modified locally, e.g., a write has occurred, the offset range associated with the write can be used to determine which cloud object associated with the file is being modified. A new cloud object can be stored with the write data, while the previous cloud object is retained in cloud storage. The mapping, stored within the stub file can updated to reference the new cloud object for the region of the file that was modified. In addition, mapping can be retained for the previous version of the file allowing for efficient recall of past versions of files.