Patents by Inventor Huan-Cheng Chang
Huan-Cheng Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230103404Abstract: A detection system and a portable detection device for detecting an object of interest in a lateral flow immunoassay strip. The lateral flow immunoassay strip has a detection carrier and a reporter, the detection carrier has a control zone and a test zone. The detection system has a laser light source, a scanning and spatial modulation module, a signal acquisition assembly, and a processing device. The laser light source provides a laser light. The scanning and spatial modulation module receives the laser light, and then provides a scanning and spatially modulating laser beam for irradiating a lateral flow immunoassay strip to generate a detecting signal. The signal acquisition assembly receives the detecting signal. The processing device electronic connects to the signal acquisition assembly and receives the detecting signal from the signal acquisition assembly.Type: ApplicationFiled: October 4, 2022Publication date: April 6, 2023Inventors: Huan-Cheng CHANG, Yuen-Yung HUI, Yi-Xiu TANG
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Patent number: 11366119Abstract: This invention is a functionalized diamond crystal with high dispersibility in high ionic strength solution and/or with specific targeting ability, which comprise a diamond crystal and a fatty acid layer. The fatty acid layer works a surfactant and provides a specific targeting feature for the diamond crystal. The feature of the surfactant makes the diamond crystal being easily dispersed in biological surrounding (e.g., phosphate saline buffer) and the feature of specific targeting ability provides the diamond crystal with specific recognizing specific targets. This invention allows researchers to use diamond crystal as a marker for specific labelling.Type: GrantFiled: May 25, 2018Date of Patent: June 21, 2022Assignee: ACADEMIA SINICAInventors: Huan-Cheng Chang, Feng-Jen Hsieh, Yen-Wei Chen
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Publication number: 20220120757Abstract: The present disclosure discloses a detection method and a detection system for detecting an object of interest in a biological sample. The detection method comprises the following steps: providing a detection kit comprising a detection carrier and a reporter, wherein the detection carrier comprises a coating protein having a recognition site for binding the object of interest, the reporter including a spin luminescent material; mixing the reporter and the biological sample and loading the mixture onto the detection carrier; placing the detection carrier with the mixture of the reporter molecule and the biological sample in a time-varied physical field; irradiating a detection carrier placed in the time-varied physical field with an excitation light to excite the spin luminescent material to generate a fluorescence signal modulated by the time-varied physical field; and receiving and analyzing the fluorescence signal.Type: ApplicationFiled: October 15, 2021Publication date: April 21, 2022Inventors: Huan-Cheng CHANG, Yuen-Yung HUI, Hsin-Hung LIN, Oliver Y. CHEN
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Patent number: 11029421Abstract: The present disclosure provides a fluorescent nitrogen-vacancy diamond (FNVD) having a plurality of nitrogen-vacancy centers with a concentration about 1 ppm to 10,000 ppm. The FNVD as built-in fluorophores exhibit a nearly constant emission profile over 540 nm to 850 nm upon excitation by vacuum ultraviolet (VUV), extreme ultraviolet (EUV) and X-rays for the energy larger than 6.2 eV. Applying the FNVD sensor can measure VUV/EUV/X-rays as a sensing sheet, manufacturing method and uses thereof, sensor and lithography apparatus. The superb photostability and broad applicability of FNVDs offer a promising solution for the long-standing problem of lacking robust and reliable detectors for VUV, EUV, and X-rays.Type: GrantFiled: August 30, 2019Date of Patent: June 8, 2021Assignees: National Synchrotron Radiation Research Center, Academia SinicaInventors: Bing-Ming Cheng, Hsiao-Chi Lu, Jen-Iu Lo, Huan-Cheng Chang
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Publication number: 20210063587Abstract: The present disclosure provides a fluorescent nitrogen-vacancy diamond (FNVD) having a plurality of nitrogen-vacancy centers with a concentration about 1 ppm to 10,000 ppm. The FNVD as built-in fluorophores exhibit a nearly constant emission profile over 540 nm to 850 nm upon excitation by vacuum ultraviolet (VUV), extreme ultraviolet (EUV) and X-rays for the energy larger than 6.2 eV. Applying the FNVD sensor can measure VUV/EUV/X-rays as a sensing sheet, manufacturing method and uses thereof, sensor and lithography apparatus. The superb photostability and broad applicability of FNVDs offer a promising solution for the long-standing problem of lacking robust and reliable detectors for VUV, EUV, and X-rays.Type: ApplicationFiled: August 30, 2019Publication date: March 4, 2021Inventors: BING-MING CHENG, HSIAO-CHI LU, JEN-IU LO, HUAN-CHENG CHANG
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Patent number: 10255896Abstract: A sound-absorbing mask is configured for covering a mouth. The sound-absorbing mask includes a covering body, a ventilation structure and a sound-absorbing portion. The covering body has a first chamber, a first and a second openings. The first chamber communicates with the first and the second openings. The first opening corresponds to the mouth. The ventilation structure is disposed at the second opening and has a second chamber, a third and a fourth openings. The second chamber communicates with the third and the fourth openings. The fourth opening is away from the first opening. The ventilation structure includes a plate disposed in the second chamber. The plate has a functioning surface facing the third opening. An edge of the plate and an inner wall of the ventilation structure have a gap in between. The sound-absorbing portion is disposed between the ventilation structure and the first opening.Type: GrantFiled: April 24, 2017Date of Patent: April 9, 2019Inventor: Huan-Cheng Chang
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Publication number: 20180340938Abstract: This invention is a functionalized diamond crystal with high dispersibility in high ionic strength solution and/or with specific targeting ability, which comprise a diamond crystal and a fatty acid layer. The fatty acid layer works a surfactant and provides a specific targeting feature for the diamond crystal. The feature of the surfactant makes the diamond crystal being easily dispersed in biological surrounding (e.g., phosphate saline buffer) and the feature of specific targeting ability provides the diamond crystal with specific recognizing specific targets. This invention allows researchers to use diamond crystal as a marker for specific labelling.Type: ApplicationFiled: May 25, 2018Publication date: November 29, 2018Inventors: Huan-Cheng CHANG, Feng-Jen HSIEH, Yen-Wei CHEN
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Publication number: 20180018951Abstract: A sound-absorbing mask is configured for covering a mouth. The sound-absorbing mask includes a covering body, a ventilation structure and a sound-absorbing portion. The covering body has a first chamber, a first and a second openings. The first chamber communicates with the first and the second openings. The first opening corresponds to the mouth. The ventilation structure is disposed at the second opening and has a second chamber, a third and a fourth openings. The second chamber communicates with the third and the fourth openings. The fourth opening is away from the first opening. The ventilation structure includes a plate disposed in the second chamber. The plate has a functioning surface facing the third opening. An edge of the plate and an inner wall of the ventilation structure have a gap in between. The sound-absorbing portion is disposed between the ventilation structure and the first opening.Type: ApplicationFiled: April 24, 2017Publication date: January 18, 2018Inventor: HUAN-CHENG CHANG
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Patent number: 8963075Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.Type: GrantFiled: December 11, 2008Date of Patent: February 24, 2015Assignee: Academia SinicaInventors: Chung Hsuan Chen, Wen-Ping Peng, Ming Lee Chu, Huan Cheng Chang, Huan-Chang Lin
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Patent number: 8168413Abstract: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm and the ion beam has a kinetic energy of 1 KeV to 900 MeV. Also disclosed are luminescent diamond particles prepared by this method and methods of using them.Type: GrantFiled: November 13, 2007Date of Patent: May 1, 2012Assignee: Academia SinicaInventors: Huan-Cheng Chang, Wunshain Fann, Chau-Chung Han
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Patent number: 7645987Abstract: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.Type: GrantFiled: September 22, 2005Date of Patent: January 12, 2010Assignee: Academia SinicaInventors: Huan-Cheng Chang, Chung-Hsuan Chen
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Publication number: 20090246887Abstract: A diamond-based composition that contains (1) a diamond crystallite having chemically derivatized surface groups, and (2) a polymer having functional groups, in which a portion of the functional groups bind to the chemically derivatized surface groups non-covalently. Also disclosed are methods of using such composition for analyzing a biological sample by determining the identity of biomolecules bound to the composition.Type: ApplicationFiled: March 25, 2009Publication date: October 1, 2009Applicant: Academia SinicaInventors: Huan-cheng Chang, Chau-chung Han
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Publication number: 20090189069Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.Type: ApplicationFiled: December 11, 2008Publication date: July 30, 2009Inventors: Chung Hsuan Chen, Wen-Ping Peng, Ming Lee Chu, Huan Cheng Chang, Huan-Chang Lin
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Publication number: 20080118966Abstract: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm and the ion beam has a kinetic energy of 1 KeV to 900 MeV. Also disclosed are luminescent diamond particles prepared by this method and methods of using them.Type: ApplicationFiled: November 13, 2007Publication date: May 22, 2008Applicant: Academia SinicaInventors: Huan-Cheng Chang, Wunshain Fann, Chau-Chung Han
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Patent number: 7326837Abstract: A method for profiling proteins in a biological sample by mixing the sample and a diamond-based composition. The diamond-based composition includes a diamond crystallite having a surface that contains chemically derivatized surface groups and a polymer having a plurality of functional groups non-covalently bound to the surface groups. Proteins in the sample are mixed with and allowed to bind to the diamond-based composition. The bound proteins are then profiled.Type: GrantFiled: February 23, 2006Date of Patent: February 5, 2008Assignee: Academia SinicaInventors: Chau-Chung Han, Huan-Cheng Chang, Sheng-Chung Lee, Wei-Hao Chen
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Publication number: 20070131871Abstract: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.Type: ApplicationFiled: September 22, 2005Publication date: June 14, 2007Inventors: Huan-Cheng Chang, Chung-Hsuan Chen
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Patent number: 7161147Abstract: A method for identifying a biological organism that includes providing a biological sample corresponding to the biological organism, ionizing the biological sample to produce an ionized sample of the biological sample, performing a mass spectrometry analysis of the ionized sample, and identifying the biological organism in accordance with the mass spectrometry analysis.Type: GrantFiled: May 20, 2005Date of Patent: January 9, 2007Assignee: Academia SinicaInventors: Huan-Cheng Chang, Joseph W. Ting
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Publication number: 20060284074Abstract: A method for identifying a biological organism that includes providing a biological sample corresponding to the biological organism, ionizing the biological sample to produce an ionized sample of the biological sample, performing a mass spectrometry analysis of the ionized sample, and identifying the biological organism in accordance with the mass spectrometry analysis.Type: ApplicationFiled: May 20, 2005Publication date: December 21, 2006Inventors: Huan-Cheng Chang, Joseph Ting
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Patent number: 7119331Abstract: A nanoparticle ion detector includes an ion trap that receives charged particles ejected from a mass selection device. A laser beam illuminates the particles to induce fluorescence, which is detected by the photon detector. Particles are periodically dumped from the ion trap. A mass spectrum of the charged particles can be obtained by comparing signals from the photon detector with the particle ejection characteristics of the mass selection device.Type: GrantFiled: December 1, 2003Date of Patent: October 10, 2006Assignee: Academia SinicaInventors: Huan-Cheng Chang, Wen-Ping Peng, Yong Cai
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Publication number: 20060154259Abstract: A diamond-based composition that contains (1) a diamond crystallite having chemically derivatized surface groups, and (2) a polymer having functional groups, in which a portion of the functional groups bind to the chemically derivatized surface groups non-covalently. Also disclosed are methods of using such composition for analyzing a biological sample by determining the identity of biomolecules bound to the composition.Type: ApplicationFiled: January 7, 2005Publication date: July 13, 2006Inventors: Huan-Cheng Chang, Chau-Chung Han