Abstract: The present disclosure discloses a preparation method of fatty acid-based VC liposomes, and belongs to the field of pharmaceutical preparations. In the disclosure, a complex of industrial conjugated linoleic acid and other fatty acids with sodium dodecyl sulfate is taken as a capsule material, which is self-assembled to embed vitamin C in an aqueous phase under an acidic condition (pH<7) to form the fatty acid-based vitamin C liposome. The preparation method of the disclosure does not use organic solvents and other substances harmful to the human body, and has the characteristics of safety and health. In addition to VC encapsulation under the acidic condition, the prepared fatty acid-based liposome can play a role in slowly releasing VC.

Abstract: Disclosed are a motion-sensing in-vehicle alerting method, a system, and a related device, which are applied to vehicles. The method includes steps of: obtaining, by a controller, an audio signal from an in-vehicle audio bus; performing an acoustic characteristics analysis on the audio signal, and extracting an acoustic waveform of the audio signal in a time domain waveform; performing an amplitude modulation on a sinusoidal signal of the acoustic waveform to obtain a modulated sinusoidal signal after amplitude modulation; obtaining, by the controller, a control signal indicating operational behavior information from an in-vehicle control bus, matching the control signal with the modulated sinusoidal signal according to a predetermined rule to generate a vibration signal, and transmitting the vibration signal to the excitation oscillator to achieve a vibration alert. The method of the present application not only enhances safety, but also provides the vibration alert, resulting in an improved user experience.

Abstract: The present disclosure provides a method, apparatus, medium and device for extracting a river drying-up region and frequency, and belongs to the technical field of remote sensing. The method for extracting a river drying-up region and frequency can be applied to efficiently acquiring river drying-up information for a long time within the large spatial region. With the inverse normalized difference water index (iNDWI) and the maximum value composite (MVC) method for the remote sensing images, the present disclosure omits the troublesome step of separately extracting a river range for each image in the conventional method. In addition, the present disclosure quickly obtains the drying-up frequency by counting the total number of available images and the number of non-water images at the same pixel position, and yields a greater efficiency for extracting the river drying-up region and frequency.

Abstract: A two-component adhesive composition is provided. The two-component adhesive composition comprises an isocyanate component, an isocyanate-reactive component and an polyether amine-epoxy silane adduct, and can achieve superior adhesion strength between the adhesive and a substrate like metal alloy substrate. A laminated article prepared with said composition, a method for preparing the article and the use of the polyether amine-epoxy silane adduct as adhesion promoter in a two-component polyurethane adhesive composition are also provided.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: The present disclosure relates to a chip-on-film bonding structure, a display module, and a terminal equipment. The chip-on-film bonding structure includes: a chip on film including a first pin, the first pin including a first end and a second end that are arranged to be opposite to each other; and a flexible circuit board including a second pin connected to the first pin, the second pin including a third end and a fourth end that are arranged to be opposite to each other; in which the first end and the third end overlap to form a first active contact region; and the second end and the fourth end respectively extend outward from two opposite sides of the first active contact region, to form a first exposed region at the second end and to form a second exposed region at the fourth end.

Abstract: A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.

Abstract: A display device includes first and second camera regions, a function integrating region, and an ambient light sensing region. A display panel has a first through hole in the first camera region, a second through hole in the second camera region, and a non-display region between the through holes. A cover panel is provided on the display side of the display panel. A grid glue has an orthographic projection of the first openings of the two camera regions and has an area greater than an orthographic projection of the through holes. A rigid heat dissipating layer has a second opening in all the four adjacent regions, and an orthographic projection of the second openings has an area greater than the orthographic projection of the first openings, and a photosensitive module defines an orthographic projection with an area greater than the orthographic projections of the first openings and the second openings.

Abstract: A computer-implemented process for training a neural network having a plurality of transform layers includes the following operations. Input data for one transform layer of the plurality of transform layers is transformed by the one transform layer into output data. A neural-backed decision tree is generated for the transform layer, a neural-backed decision tree. The transforming and the generating are repeated for each of the plurality of transform layers. A neural-backed decision tree map for a particular one of the plurality of transform layers maps output data of the particular one of the plurality of transform layers into a list of interpretable words from a generative search domain of facts and evidence.

Abstract: Provided is a perfusion culture method for CAR-T cells. The method comprises the following steps: 1) separating peripheral blood mononuclear cells from a single blood cell of a subject, and sorting the mononuclear cells to obtain T cells; 2) carrying out activation treatment on the separated T cells by using CD3/CD28 stimulation magnetic beads; 3) infecting the activated T cells by using a lentiviral vector; 4) carrying out perfusion culture on the lentivirus-infected T cells, and harvesting CAR-T cells, wherein the composition of a serum-free culture medium, which does not contain an animal-derived component, for culturing the CAR-T cells is: AIM-V+(3-9)% ISR; and the perfusion culture comprises the following stages: the first stage: when the cell density is (0.5-1.1)×106 cells/mL, the perfusion rate is A1, and/or the second stage: when the cell density is (1.

Abstract: A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.

Abstract: The present disclosure relates to a circuit board structure, display panel, display device and manufacturing method. The circuit board structure includes a circuit board body, a first connection part, a second connection part and a connection circuit board. An accommodating hole is disposed on the circuit board body. The first connection part is disposed on the circuit board body and located at a side of the accommodating hole. The second connection part is disposed on the circuit board body and located at a side of the accommodating hole away from the first connection part. The connection circuit board is provided with a plurality of connection wires thereon, and the connection wires conductively connect the first and second connection parts. An orthographic projection of the connection circuit board on the circuit board body is not overlapped with that of the accommodating hole on the circuit board body.

Abstract: In various embodiments, drug delivery vehicles that contain one or more metal-based therapeutic agents are provided. In certain embodiments, the drug delivery vehicle comprises: a silica nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication with the outside surface of the nanoparticle; a metal-based (e.g., platinum-based) chemotherapeutic drug disposed on the surface of the nanoparticle and/or within the one or more cavities of the nanoparticle where the drug comprises a cationic, metal-based drug; and a lipid bilayer disposed on the surface of the nanoparticle where the lipid bilayer fully encapsulates and seals the nanoparticle.

Abstract: Provided is a terminal device, including a photosensitive element, a display panel provided with a light-transmitting region, and a circuit board disposed between the photosensitive element and the display panel and being provided with a light-transmitting hole. The light-transmitting region is a region where light is able to pass through the display panel. The light-transmitting hole is disposed between the photosensitive element and the light-transmitting region of the display panel in a direction perpendicular to a light-exiting surface of the display panel.

Abstract: In various embodiments, methods of treating a cancer are provided. In certain embodiments, the methods comprise administering to a mammal in need thereof i) one or more checkpoint inhibitor(s); and ii) one or more camptothecin analogs, and, optionally, or one or more autophagy inhibitors wherein said camptothecin analog, and one or more autophagy inhibitors, when present, are provided inside a delivery vehicle where said delivery vehicle comprises: a nanoparticle comprising one or more cavities disposed within said nanoparticle and an outside surface where said one or more cavities are in fluid communication the outside surface of said nanoparticle; said one or more camptothecin analog, one or more autophagy inhibitors, when present, are disposed within said one or more cavities; and a lipid bilayer is disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates the nanoparticle.

Abstract: In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Abstract: In certain embodiments a platform technology for the facilitating immune therapy in the treatment of cancer is provided. In certain embodiments nanocarriers are provided that facilitate delivery of an IDO inhibitor in conjunction with an inducer of cell death (ICD-inducer). In certain embodiments the IDO inhibitor is conjugated to a component of a lipid bilayer forming a nanovesicle. In still another embodiment, methods and compositions are provided where an ICD-inducing agent (e.g., doxorubicin, oxaliplatin, mitoxantrone etc.) and an IDO pathway inhibitor (e.g., an IDO inhibitor-prodrug) are integrated into a nanocarrier (e.g. a lipid-bilayer (LB)-coated nanoparticle), that allows systemic delivery to orthotopic pancreatic cancer site.

Abstract: In various embodiments nanoparticle drug delivery vehicles are provided herein for the effective delivery of a GSK3 inhibitor. In certain embodiments the drug delivery vehicle comprises a nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication the outside surface of the nanoparticle; a GSK3 inhibitor disposed within said one or more cavities; and a lipid bilayer disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates said nanoparticle.

Abstract: In various embodiments immunogenic nanoparticles are provided that are capable of raising an immune response directed against one or more viral proteins and/or protein fragments. In certain embodiments the immunogenic nanoparticles raise an immune response directed against a virus (e.g., SARS-CoV-2 (2019-nCoV), SARS-CoV-2, and MERS-CoV, and the like). In certain embodiments the immunogenic nanoparticles comprise a nanoparticle formed from one or more biocompatible polymer(s), one or more viral proteins or fragments thereof encapsulated within or attached to the biocompatible polymer(s) where the viral protein or fragment thereof comprises an antigen to which an immune response is to be induced by administration of the immunogenic nanoparticle to a mammal and where the immunogenic nanoparticle further comprises an adjuvant (e.g., a STING agonist).

Abstract: A display device includes first and second camera regions, a function integrating region, and an ambient light sensing region. A display panel has a first through hole in the first camera region, a second through hole in the second camera region, and a non-display region between the through holes. A cover panel is provided on the display side of the display panel. A grid glue has an orthographic projection of the first openings of the two camera regions and has an area greater than an orthographic projection of the through holes. A rigid heat dissipating layer has a second opening in all the four adjacent regions, and an orthographic projection of the second openings has an area greater than the orthographic projection of the first openings, and a photosensitive module defines an orthographic projection with an area greater than the orthographic projections of the first openings and the second openings.