Abstract: A light-emitting diode includes an epitaxial structure and a first metal electrode. The epitaxial structure has a first surface and a second surface opposite thereto, and includes a first-type semiconductor layer, a light-emitting layer and a second-type semiconductor layer. The first-type semiconductor layer includes an ohmic contact layer which at least partially defines the first surface. The first metal electrode is disposed on the first surface, and includes a main electrode and auxiliary electrodes which are disposed on and electrically connected to the ohmic contact layer. The ohmic contact layer is made of AlxGayInP, where 0?x?1 or 0?y?1. In a top view of the light-emitting layer, a projection of each auxiliary electrode on the first surface is smaller than or equal to that of the ohmic contact layer on the first surface. A light-emitting divide including the light-emitting diode, and a method for manufacturing the light-emitting diode are also provided.

Abstract: A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures.

Abstract: The present disclosure relates to a circuit board structure, display panel, display device and manufacturing method. The circuit board structure includes a circuit board body, a first connection part, a second connection part and a connection circuit board. An accommodating hole is disposed on the circuit board body. The first connection part is disposed on the circuit board body and located at a side of the accommodating hole. The second connection part is disposed on the circuit board body and located at a side of the accommodating hole away from the first connection part. The connection circuit board is provided with a plurality of connection wires thereon, and the connection wires conductively connect the first and second connection parts. An orthographic projection of the connection circuit board on the circuit board body is not overlapped with that of the accommodating hole on the circuit board body.

Abstract: In various embodiments, drug delivery vehicles that contain one or more metal-based therapeutic agents are provided. In certain embodiments, the drug delivery vehicle comprises: a silica nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication with the outside surface of the nanoparticle; a metal-based (e.g., platinum-based) chemotherapeutic drug disposed on the surface of the nanoparticle and/or within the one or more cavities of the nanoparticle where the drug comprises a cationic, metal-based drug; and a lipid bilayer disposed on the surface of the nanoparticle where the lipid bilayer fully encapsulates and seals the nanoparticle.

Abstract: Provided is a terminal device, including a photosensitive element, a display panel provided with a light-transmitting region, and a circuit board disposed between the photosensitive element and the display panel and being provided with a light-transmitting hole. The light-transmitting region is a region where light is able to pass through the display panel. The light-transmitting hole is disposed between the photosensitive element and the light-transmitting region of the display panel in a direction perpendicular to a light-exiting surface of the display panel.

Abstract: In various embodiments, methods of treating a cancer are provided. In certain embodiments, the methods comprise administering to a mammal in need thereof i) one or more checkpoint inhibitor(s); and ii) one or more camptothecin analogs, and, optionally, or one or more autophagy inhibitors wherein said camptothecin analog, and one or more autophagy inhibitors, when present, are provided inside a delivery vehicle where said delivery vehicle comprises: a nanoparticle comprising one or more cavities disposed within said nanoparticle and an outside surface where said one or more cavities are in fluid communication the outside surface of said nanoparticle; said one or more camptothecin analog, one or more autophagy inhibitors, when present, are disposed within said one or more cavities; and a lipid bilayer is disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates the nanoparticle.

Abstract: In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Abstract: In various embodiments nanoparticle drug delivery vehicles are provided herein for the effective delivery of a GSK3 inhibitor. In certain embodiments the drug delivery vehicle comprises a nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication the outside surface of the nanoparticle; a GSK3 inhibitor disposed within said one or more cavities; and a lipid bilayer disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates said nanoparticle.

Abstract: In certain embodiments a platform technology for the facilitating immune therapy in the treatment of cancer is provided. In certain embodiments nanocarriers are provided that facilitate delivery of an IDO inhibitor in conjunction with an inducer of cell death (ICD-inducer). In certain embodiments the IDO inhibitor is conjugated to a component of a lipid bilayer forming a nanovesicle. In still another embodiment, methods and compositions are provided where an ICD-inducing agent (e.g., doxorubicin, oxaliplatin, mitoxantrone etc.) and an IDO pathway inhibitor (e.g., an IDO inhibitor-prodrug) are integrated into a nanocarrier (e.g. a lipid-bilayer (LB)-coated nanoparticle), that allows systemic delivery to orthotopic pancreatic cancer site.

Abstract: In various embodiments immunogenic nanoparticles are provided that are capable of raising an immune response directed against one or more viral proteins and/or protein fragments. In certain embodiments the immunogenic nanoparticles raise an immune response directed against a virus (e.g., SARS-CoV-2 (2019-nCoV), SARS-CoV-2, and MERS-CoV, and the like). In certain embodiments the immunogenic nanoparticles comprise a nanoparticle formed from one or more biocompatible polymer(s), one or more viral proteins or fragments thereof encapsulated within or attached to the biocompatible polymer(s) where the viral protein or fragment thereof comprises an antigen to which an immune response is to be induced by administration of the immunogenic nanoparticle to a mammal and where the immunogenic nanoparticle further comprises an adjuvant (e.g., a STING agonist).

Abstract: A display device includes first and second camera regions, a function integrating region, and an ambient light sensing region. A display panel has a first through hole in the first camera region, a second through hole in the second camera region, and a non-display region between the through holes. A cover panel is provided on the display side of the display panel. A grid glue has an orthographic projection of the first openings of the two camera regions and has an area greater than an orthographic projection of the through holes. A rigid heat dissipating layer has a second opening in all the four adjacent regions, and an orthographic projection of the second openings has an area greater than the orthographic projection of the first openings, and a photosensitive module defines an orthographic projection with an area greater than the orthographic projections of the first openings and the second openings.

Abstract: An electronic device, which includes at least a first part and a second part bonded to each other is provided. The first part includes a first bonding area. The first bonding area includes at least one first testing area. The first testing area includes a plurality of testing pads. The second part includes a second boding area corresponding to the first bonding area. The second bonding area includes a plurality of testing terminals, and includes at least one second testing area respectively corresponding to the at least one first testing area. The second testing area includes a plurality of testing pins. The plurality of testing pads, the plurality of testing terminals and the plurality of testing pins are configured to form a current channel and a voltage testing channel, for measuring a resistance of bonded testing pads and testing pins on both the current channel and the voltage testing channel.

Abstract: The present disclosure relates to a circuit board structure, display panel, display device and manufacturing method. The circuit board structure includes a circuit board body, a first connection part, a second connection part and a connection circuit board. An accommodating hole is disposed on the circuit board body. The first connection part is disposed on the circuit board body and located at a side of the accommodating hole. The second connection part is disposed on the circuit board body and located at a side of the accommodating hole away from the first connection part. The connection circuit board is provided with a plurality of connection wires thereon, and the connection wires conductively connect the first and second connection parts. An orthographic projection of the connection circuit board on the circuit board body is not overlapped with that of the accommodating hole on the circuit board body.

Abstract: In certain embodiments a platform technology for the facilitating immune therapy in the treatment of cancer is provided. In certain embodiments nanocarriers are provided that facilitate delivery of an IDO inhibitor in conjunction with an inducer of cell death (ICD-inducer). In certain embodiments the IDO inhibitor is conjugated to a component of a lipid bilayer forming a nanovesicle. In still another embodiment, methods and compositions are provided where an ICD-inducing agent (e.g., doxorubicin, oxaliplatin, mitoxantrone etc.) and an IDO pathway inhibitor (e.g., an IDO inhibitor-prodrug) are integrated into a nanocarrier (e.g. a lipid-bilayer (LB)-coated nanoparticle), that allows systemic delivery to orthotopic pancreatic cancer site.

Abstract: A terminal device includes: a rear housing, and a photosensitive element disposed on the rear housing; a light-transmissive cover plate provided with an edge window region coated with ink, wherein the edge window region includes a light-transmissive ink region; and a display panel provided with an edge light-transmissive region, wherein at least a portion of the edge light-transmissive region is disposed between the light-transmissive ink region and the photosensitive element, and both the edge light-transmissive region and the light-transmissive ink region are regions transmittable to light.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: An electronic device, which includes at least a first part and a second part bonded to each other is provided. The first part includes a first bonding area. The first bonding area includes at least one first testing area. The first testing area includes a plurality of testing pads. The second part includes a second boding area corresponding to the first bonding area. The second bonding area includes a plurality of testing terminals, and includes at least one second testing area respectively corresponding to the at least one first testing area. The second testing area includes a plurality of testing pins. The plurality of testing pads, the plurality of testing terminals and the plurality of testing pins are configured to form a current channel and a voltage testing channel, for measuring a resistance of bonded testing pads and testing pins on both the current channel and the voltage testing channel.

Abstract: A terminal device includes: a rear housing, and a photosensitive element disposed on the rear housing; a light-transmissive cover plate provided with an edge window region coated with ink, wherein the edge window region includes a light-transmissive ink region; and a display panel provided with an edge light-transmissive region, wherein at least a portion of the edge light-transmissive region is disposed between the light-transmissive ink region and the photosensitive element, and both the edge light-transmissive region and the light-transmissive ink region are regions transmittable to light.

Abstract: The present disclosure relates to a chip-on-film bonding structure, a display module, and a terminal equipment. The chip-on-film bonding structure includes: a chip on film including a first pin, the first pin including a first end and a second end that are arranged to be opposite to each other; and a flexible circuit board including a second pin connected to the first pin, the second pin including a third end and a fourth end that are arranged to be opposite to each other; in which the first end and the third end overlap to form a first active contact region; and the second end and the fourth end respectively extend outward from two opposite sides of the first active contact region, to form a first exposed region at the second end and to form a second exposed region at the fourth end.

Abstract: Provided is a terminal device, including a photosensitive element, a display panel provided with a light-transmitting region, and a circuit board disposed between the photosensitive element and the display panel and being provided with a light-transmitting hole. The light-transmitting region is a region where light is able to pass through the display panel. The light-transmitting hole is disposed between the photosensitive element and the light-transmitting region of the display panel in a direction perpendicular to a light-exiting surface of the display panel.