Abstract: Disclosed herein are antibodies and compositions used for binding to Gal3. Some embodiments allow for disrupting interactions between Galectin-3 (Gal3) and cell surface markers and/or proteins associated with neurological diseases and/or proteopathies, such as Alzheimer's disease. Additionally, disclosed herein are methods of treatment and uses of the antibodies or binding fragments thereof for the treatment of fibrosis, liver fibrosis, kidney fibrosis, cardiac fibrosis, pulmonary fibrosis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, sepsis, atopic dermatitis, psoriasis, cancer, brain cancer, breast cancer, colorectal cancer, kidney cancer, liver cancer, lung cancer, pancreatic cancer, bladder cancer, stomach cancer, hematological malignancy, neurological diseases and/or proteopathies. Furthermore, some embodiments provided herein can cross the blood-brain barrier and can be conjugated or otherwise associated with one or more payloads for the treatment of a neurological disease.

Abstract: Disclosed herein are methods, antibodies, and compositions for disrupting an interaction between Galectin-3 (Gal3) and viral proteins, such as proteins of the SARS-CoV-2 virus or other coronaviruses, or viral-associated host proteins. Further disclosed herein are methods, medicaments, and compositions for the treatment of a disease or a disorder in a subject, such as the treatment of a viral infection, or treatment of a fibrosis, such as lung fibrosis, that develop as a sequela of a viral infection, or cytokine release syndrome. Further disclosed herein are methods, medicaments, and compositions for the treatment of an inflammatory disease or disorder, such as inflammation of the lungs or systemic lupus erythematosus, which may be associated with neutrophil activity, in a subject. Also disclosed herein are pharmaceutical antibody formulations for the treatment of a disease, such as a coronavirus infection.

Abstract: A fan noise control method includes being activated by a power-on signal to perform: controlling a rotation speed of a fan not to be greater than a first predetermined rotation speed, obtaining a power consumption of a computing device, obtaining a first temperature, wherein the first temperature is a temperature of the computing device, obtaining a second temperature, wherein the second temperature is not the temperature of the computing device, and switching from controlling the rotation speed of the fan not to be greater than the first predetermined rotation speed to controlling the rotation speed of the fan according to the first temperature when the power consumption of the computing device is greater than a first predetermined power consumption, or the second temperature is greater than a predetermined temperature.

Abstract: A method is provided for fabricating a cathode film layer of lithium ion batteries through atmospheric plasma spraying (APS) without using polymer adhesive. The ratio of active substance can approach 100%. A cathode film layer fabricated by APS is porous, where, with the coordination of a liquid electrolyte, electrolyte penetration paths are provided to significantly increase the area of reaction. Hence, the effective thickness of the film layer is relatively thick and the capacity of battery is increased. As an example, the thickness of a film layer of lithium cobalt oxide fabricated accordingly reaches more than 100 microns and its maximum electric capacity per unit area reaches 6 milliampere-hours per square centimeter (mAh/cm2).

Abstract: A switch device includes a driver circuit, a switch circuit and a level transition circuit. The driver circuit includes an input terminal for receiving an input signal, an output terminal for outputting an output signal, a first terminal coupled to a first reference terminal, and a second terminal coupled to a second reference terminal. The switch circuit includes a control terminal for receiving the output signal. The level transition circuit includes a first terminal for receiving the output signal, a second terminal coupled to a third reference terminal, and a third terminal for receiving the input signal. In a transition interval, the input signal is transitioned from a first input signal level to a second input signal level, the level transition circuit transitions the output signal from a first output signal level to a third output signal level between the first output signal level and a second output signal level.

Abstract: A housing structure manufacturing method and an electronic device are provided. The housing structure manufacturing method includes providing a plurality of memory polymeric materials, heating the plurality of memory polymeric materials, and forming the housing structure having a first morphology by printing the plurality of memory polymeric materials that are heated.

Abstract: A hot plate cooling system is provided, configured to cool a hot plate, including a chamber and a cooling module. The hot plate is placed in the chamber. The cooling module extends into the chamber and faces the hot plate. The cooling module includes a nozzle member, a shell member, and a discharge channel. The nozzle member faces the hot plate for spraying a working fluid onto the hot plate. The shell member has a receiving groove surrounding the nozzle member. The discharge channel is connected to the shell member and communicates with the receiving groove. When the nozzle member sprays the working fluid to cool the hot plate, the working fluid is conveyed through the nozzle member toward a surface of the hot plate, and the working fluid is sequentially discharged from the hot plate cooling system through the receiving groove to the discharge channel.

Abstract: A switch device includes a first switch unit, a second switch unit, a first sub-switch unit, a second sub-switch unit, a first resistor and a second resistor. The first switch unit is coupled to a radio-frequency terminal and coupled to the second switch unit in cascode. The first sub-switch unit is coupled to the second sub-switch unit in cascode. The first sub-switch unit is further coupled between control terminals of the first switch unit and the second switch unit. The first sub-switch unit is further coupled to a node between the first resistor and the first switch unit. The second sub-switch unit is further coupled to a node between the second resistor and the second switch unit. When the first switch unit and the second switch unit are transitioned, the first sub-switch unit and the second sub-switch unit can be turned on to discharge and/or neutralize accumulated charges.

Abstract: A switch device includes a first switch unit, a second switch unit, a first sub-switch unit, a second sub-switch unit, a first resistor and a second resistor. The first switch unit is coupled to a radio-frequency terminal and coupled to the second switch unit in cascode. The first sub-switch unit is coupled to the second sub-switch unit in cascode. The first sub-switch unit is further coupled between control terminals of the first switch unit and the second switch unit. The first sub-switch unit is further coupled to a node between the first resistor and the first switch unit. The second sub-switch unit is further coupled to a node between the second resistor and the second switch unit. When the first switch unit and the second switch unit are transitioned, the first sub-switch unit and the second sub-switch unit can be turned on to discharge and/or neutralize accumulated charges.

Abstract: A switch device includes a driver circuit, a switch circuit and a level transition circuit. The driver circuit includes an input terminal for receiving an input signal, an output terminal for outputting an output signal, a first terminal coupled to a first reference terminal, and a second terminal coupled to a second reference terminal. The switch circuit includes a control terminal for receiving the output signal. The level transition circuit includes a first terminal for receiving the output signal, a second terminal coupled to a third reference terminal, and a third terminal for receiving the input signal. In a transition interval, the input signal is transitioned from a first input signal level to a second input signal level, the level transition circuit transitions the output signal from a first output signal level to a third output signal level between the first output signal level and a second output signal level.

Abstract: A voltage state detector includes a voltage drop circuit, a pull-down circuit, a load circuit, a transistor, a pull-up circuit, first and second output terminals, and a logic circuit. The pull-down circuit is coupled to the voltage drop circuit. The transistor has a first terminal coupled to the load circuit, a second terminal coupled to the pull-down circuit, and a control terminal coupled to the voltage drop circuit. The pull-up circuit is coupled to the load circuit and the voltage drop circuit. The first output terminal is coupled to the first terminal of the transistor for outputting a first state determination signal. The second output terminal is coupled to the voltage drop circuit for outputting a second state determination signal. The logic circuit includes a NOR gate for performing an NOR operation on the first state determination signal and the second state determination signal to output a control signal.

Abstract: A voltage state detector includes a voltage drop circuit, a pull-down circuit, a load circuit, a transistor, a pull-up circuit, first and second output terminals, and a logic circuit. The pull-down circuit is coupled to the voltage drop circuit. The transistor has a first terminal coupled to the load circuit, a second terminal coupled to the pull-down circuit, and a control terminal coupled to the voltage drop circuit. The pull-up circuit is coupled to the load circuit and the voltage drop circuit. The first output terminal is coupled to the first terminal of the transistor for outputting a first state determination signal. The second output terminal is coupled to the voltage drop circuit for outputting a second state determination signal. The logic circuit includes a NOR gate for performing an NOR operation on the first state determination signal and the second state determination signal to output a control signal.

Abstract: Disclosed herein are methods and compositions for disrupting an interaction between Galectin-3 and insulin receptor or integrins. Further disclosed herein are methods and compositions for the treatment of a disease or a disorder in a subject, such as the treatment of diabetes mellitus, inflammatory bowel syndrome, non-alcoholic fatty liver disease, and nonalcoholic steatohepatitis.

Abstract: A method is provided for fabricating a film layer. A cathode film layer of lithium ion batteries is fabricated through atmospheric plasma spraying (APS) without using polymer adhesive. The ratio of its active substance can even reach 100%. Moreover, the cathode film layer fabricated by APS obtains pores, where, with the coordination of a liquid electrolyte, electrolyte penetration paths are provided to significantly increase the area of reaction. Hence, the effective thickness of the film layer is relatively thick and the capacity of battery is increased. As an example, the thickness of a film layer of lithium cobalt oxide fabricated accordingly reaches more than 100 microns; and its maximum electric capacity per unit area reaches 6 milliampere-hours per square centimeter (mAh/cm2). Thus, the performance of the follow-on solid-state lithium-ion battery is improved and its high-volume manufacturing cost is reduced.

Abstract: A voltage state detector includes an input terminal, a voltage drop circuit, a pull-down circuit, a load circuit, a transistor, a pull-up circuit, a first output terminal, and a second output terminal. The voltage drop circuit is coupled to the input terminal. The pull-down circuit is coupled to the voltage drop circuit and a first reference terminal. The load circuit is coupled to a second reference terminal. The transistor has a first terminal coupled to the load circuit, a second terminal coupled to the first reference terminal, and a control terminal coupled to the voltage drop circuit. The pull-up circuit is coupled to the second reference terminal and the voltage drop circuit. The first output terminal is coupled to the first terminal of the transistor for outputting a first state determination signal. The second output terminal is coupled to the voltage drop circuit for outputting a second state determination signal.

Abstract: A driving circuit includes a first reference terminal, a second reference terminal, at least one input terminal, an output terminal, a first transistor, a second transistor, a switch module, and at least one control signal terminal. The at least one input terminal receives at least one input signal. The output terminal outputs an output signal in response to the at least one input signal. The first transistor and the second transistor respectively include control terminals coupled to the at least one input terminal. The switch module includes at least one control terminal coupled to the at least one control signal terminal to receive at least one control signal. The at least one input signal has a transition period. The switch module can be turned off according to the at least one control signal.

Abstract: Disclosed herein are antibodies and compositions used for binding to Gal3. Some embodiments allow for disrupting interactions between Galectin-3 (Gal3) and cell surface markers and/or proteins associated with neurological diseases and/or proteopathies, such as Alzheimer's disease. Additionally, disclosed herein are methods of treatment and uses of the antibodies or binding fragments thereof for the treatment of fibrosis, liver fibrosis, kidney fibrosis, cardiac fibrosis, pulmonary fibrosis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, sepsis, atopic dermatitis, psoriasis, cancer, brain cancer, breast cancer, colorectal cancer, kidney cancer, liver cancer, lung cancer, pancreatic cancer, bladder cancer, stomach cancer, hematological malignancy, neurological diseases and/or proteopathies. Furthermore, some embodiments provided herein can cross the blood-brain barrier and can be conjugated or otherwise associated with one or more payloads for the treatment of a neurological disease.

Abstract: A touch panel includes a substrate, a peripheral circuit layer, and a touch sensing electrode layer. The substrate has a visible region and a border region surrounding the visible region. The peripheral circuit layer is disposed on the substrate and located in the border region, and has at least one concave portion, in which the concave portion is located on a surface of the peripheral circuit layer facing away from the substrate. The touch sensing electrode layer is disposed in the visible region and partially extends to the border region to at least cover the concave portion, in which the touch sensing electrode layer has at least one entering portion extending into the concave portion.

Abstract: A touch panel having dummy pattern is provided, including a first metal nanowire layer and a second metal nanowire layer. The first metal nanowire layer includes first electrode wires, first axial wires connected to the first electrode wires, and first dummy patterns. The second metal nanowire layer includes a plurality of second electrode wires and a plurality of second axial wires connected to the second electrode wires. The first dummy patterns are electrically insulated and deposited outside the first electrode wires and the first axial wires, and each of the first dummy patterns comprises a plurality of first etching areas extending along the first and second directions. The first dummy patterns do not expose the first etching areas along the first direction at a vertical projection area of a part where each of the second axial wires alone exists, so that the electrode pattern is difficult to observe.

Abstract: A hot plate cooling system is provided, configured to cool a hot plate, including a chamber and a cooling module. The hot plate is placed in the chamber. The cooling module extends into the chamber and faces the hot plate. The cooling module includes a nozzle member, a shell member, and a discharge channel. The nozzle member faces the hot plate for spraying a working fluid onto the hot plate. The shell member has a receiving groove surrounding the nozzle member. The discharge channel is connected to the shell member and communicates with the receiving groove. When the nozzle member sprays the working fluid to cool the hot plate, the working fluid is conveyed through the nozzle member toward a surface of the hot plate, and the working fluid is sequentially discharged from the hot plate cooling system through the receiving groove to the discharge channel.