Patents by Inventor Huangpin Ben Hsieh
Huangpin Ben Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8268169Abstract: The water treatment system and method incorporating the use of a hydrodynamic separator to remove most of the total suspended solids (TSS) in source water being treated to thereby lighten the load on membrane filtration in the water treatment system and lower energy costs.Type: GrantFiled: December 20, 2010Date of Patent: September 18, 2012Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Joe Zuback, Nitin Parekh, Norine E. Chang, Huangpin Ben Hsieh, Kai Melde
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Publication number: 20120152814Abstract: The water treatment system and method incorporating the use of a hydrodynamic separator to remove most of the total suspended solids (TSS) in source water being treated to thereby lighten the load on membrane filtration in the water treatment system and lower energy costs.Type: ApplicationFiled: December 20, 2010Publication date: June 21, 2012Applicant: PALO ALTO RESEARCH CENTER INCORPORATEDInventors: Meng H. Lean, Joe Zuback, Nitin Parekh, Norine E. Chang, Huangpin Ben Hsieh, Kai Melde
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Publication number: 20120074074Abstract: A self-cleaning screen system and method removes contaminants from a fluid passed through a screen of the self-cleaning screen system. The self-cleaning screen system includes a cleaning mechanism used to remove contaminants which may have adhered to the screen. The self-cleaning screen system is self-powered by extracting energy from the fluid flow to cause rotation or other movement of either the screen and/or the cleaning mechanism.Type: ApplicationFiled: September 24, 2010Publication date: March 29, 2012Applicant: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Armin R. Völkel, Ashutosh Kole, Kai Melde, Huangpin Ben Hsieh
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Patent number: 7842465Abstract: A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 ?m or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.Type: GrantFiled: January 17, 2006Date of Patent: November 30, 2010Assignee: Palo Alto Research Center IncorporatedInventors: Huangpin Ben Hsieh, Nicole H. Lazarus, Robert T. Krivacic, Douglas N. Curry, Richard H. Bruce
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Publication number: 20100196914Abstract: Disclosed is a method using a large area flat panel imager which is specifically adapted for rare cell detection methods. The method generally includes an imager having a sample receiving surface which can provide a digital or electronic image of a sample deposited on the surface. The method also includes a selectively positionable microscope and/or camera which are used to obtain high resolution images of the deposited samples. An electronic controller can also be used in conjunction with the imager, microscope, and/or camera to selectively position at least one of those components to focus on desired regions of the deposited sample. The noted method is particularly adapted for use with chemiluminescence or other tagging technologies.Type: ApplicationFiled: April 15, 2010Publication date: August 5, 2010Applicant: PALO ALTO RESEARCH CENTER INCORPORATEDInventors: Huangpin Ben Hsieh, Jeng Ping Lu
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Patent number: 7727471Abstract: Disclosed is a system using a large area flat panel imager which is specifically adapted for rare cell detection methods. The system generally includes an imager having a sample receiving surface which can provide a digital or electronic image of a sample deposited on the surface. The system also includes a selectively positionable microscope and/or camera which are used to obtain high resolution images of the deposited samples. An electronic controller can also be used in conjunction with the imager, microscope, and/or camera to selectively position at least one of those components to focus on desired regions of the deposited sample. The noted system is particularly adapted for use with chemiluminescence or other tagging technologies.Type: GrantFiled: September 9, 2004Date of Patent: June 1, 2010Assignee: Palo Alto Research Center IncorporatedInventors: Huangpin Ben Hsieh, JengPeng Lu
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Patent number: 7681738Abstract: Various traveling wave grid configurations are disclosed. The grids and systems are well suited for transporting, separating, and classifying small particles dispersed in liquid or gaseous media. Also disclosed are various separation strategies and purification cells utilizing such traveling wave arrays and strategies.Type: GrantFiled: September 12, 2005Date of Patent: March 23, 2010Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Jeng Ping Lu, Scott J. Limb, Jürgen H. Daniel, Armin R. Völkel, Huangpin Ben Hsieh, Scott E. Solberg, Bryan T. Preas
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Patent number: 7538192Abstract: A technique for forming conjugates of proteins and oligonucleotides is disclosed in which conjugation is performed while the oligonucleotide is attached to support media such as glass beads. The conjugated product may then be readily removed from the support media. Also disclosed are the conjugated products formed by this technique. The present invention is particularly directed to conjugates of albumin proteins and specifically to bovine serum albumin (BSA).Type: GrantFiled: July 1, 2005Date of Patent: May 26, 2009Assignee: Palo Alto Research Center IncorporatedInventor: Huangpin Ben Hsieh
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Patent number: 7309410Abstract: Various traveling wave grids and related systems are disclosed that are particularly beneficial for the separation, transport, and focusing of biomolecules or other charged species. An implementation of a vertically integrated traveling wave module is described which allows for scalability to arbitrary gel dimensions through tiling. In addition, several unique traveling wave algorithms are also described which when used in conjunction with the traveling wave grids, impart selective motion to biomolecules or other charged species.Type: GrantFiled: December 3, 2003Date of Patent: December 18, 2007Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Jeng Ping Lu, Jackson Ho, Chinwen Shih, Armin R. Völkel, Huangpin Ben Hsieh, Jurgen Daniel
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Patent number: 7282129Abstract: An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and arrangement of the samples and resulting sample patterns.Type: GrantFiled: June 12, 2003Date of Patent: October 16, 2007Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Huangpin Ben Hsieh, John S. Fitch, Armin R. Völkel, Bryan Preas, Scott Elrod, Richard H. Bruce, Eric Peeters, Frank Torres, Michael Chabinyc
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Patent number: 7248361Abstract: A sample detection system including an anti-resonant waveguide, including a sample having a first index of refraction, a top layer and a substrate surrounding the sample, where the top layer has a second index of refraction, and the substrate has a third index of refraction. The second index of refraction, and the third index of refraction are both greater than the first index of refraction. A detection device of the system includes a low power light source used to direct light into the sample and generate an anti-resonant optical mode in the sample, and an analyzing system to detect the interaction of the light propagating in the sample.Type: GrantFiled: December 22, 2005Date of Patent: July 24, 2007Assignee: Palo Alto Research Center IncorporatedInventors: Peter Kiesel, Oliver Wolst, Michael Kneissl, Huangpin Ben Hsieh, Oliver Schmidt
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Patent number: 7163611Abstract: Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.Type: GrantFiled: December 3, 2003Date of Patent: January 16, 2007Assignee: Palo Alto Research Center IncorporatedInventors: Armin R. Völkel, Meng H. Lean, Huangpin Ben Hsieh, Jurgen Daniel
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Patent number: 7156970Abstract: Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.Type: GrantFiled: June 12, 2003Date of Patent: January 2, 2007Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Huangpin Ben Hsieh, John S. Fitch, Armin R. Völkel, Bryan Preas, Scott Elrod, Richard H. Bruce, Eric Peeters, Frank Torres, Michael Chabinyc
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Patent number: 7150813Abstract: Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.Type: GrantFiled: June 12, 2003Date of Patent: December 19, 2006Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Huangpin Ben Hsieh, John S. Fitch, Armin R. Völkel, Bryan Preas, Scott Elrod, Richard H. Bruce, Eric Peeters, Frank Torres, Michael Chabinyc
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Patent number: 7126134Abstract: A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.Type: GrantFiled: August 19, 2004Date of Patent: October 24, 2006Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Francisco E. Torres, Huangpin Ben Hsieh, Armin R. Völkel, Bryan Preas, Scott A. Elrod, John S. Fitch, Richard H. Bruce
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Patent number: 7121157Abstract: Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.Type: GrantFiled: August 6, 2004Date of Patent: October 17, 2006Assignee: Palo Alto Research Center IncorporatedInventors: Meng H. Lean, Huangpin Ben Hsieh, Armin R. Völkel, Peter Kiesel, Noble Johnson
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Patent number: 7122799Abstract: A system for conducting a polymerase chain reaction (PCR) assay upon a collection of samples is disclosed. The PCR assay is performed by absorption detection. The system includes a multi-well plate which is adapted to retain a collection of sample wells. This system includes a thermal cycler for the multi-well plate. The system additionally includes a collection of photodetectors, and a corresponding number of light sources. The light sources are positioned such that light emitted from each of the respective light sources passes through a corresponding well retained in the multi-well plate and to a corresponding photodetector. The system also includes a processor or other means for analyzing the output signals from the photodetectors. In certain versions of the system, ultra-violet light is used.Type: GrantFiled: December 18, 2003Date of Patent: October 17, 2006Assignee: Palo Alto Research Center IncorporatedInventors: Huangpin Ben Hsieh, Michael A. Kneissl
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Patent number: 6913890Abstract: A technique for forming conjugates of proteins and oligonucleotides is disclosed in which conjugation is performed while the oligonucleotide is attached to support media such as glass beads. The conjugated product may then be readily removed from the support media. Also disclosed are the conjugated products formed by this technique. The present invention is particularly directed to conjugates of albumin proteins and specifically to bovine serum albumin (BSA).Type: GrantFiled: December 18, 2002Date of Patent: July 5, 2005Assignee: Palo Alto Research Center IncorporatedInventor: Huangpin Ben Hsieh
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Publication number: 20040251135Abstract: Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.Type: ApplicationFiled: June 12, 2003Publication date: December 16, 2004Applicant: PALO ALTO RESEARCH CENTER INCORPORATEDInventors: Meng H. Lean, Huangpin Ben Hsieh, John S. Fitch, Armin R. Volkel, Bryan Preas, Scott Elrod, Richard H. Bruce, Eric Peeters, Frank Torres, Michael Chabinyc
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Publication number: 20040251139Abstract: An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and arrangement of the samples and resulting sample patterns.Type: ApplicationFiled: June 12, 2003Publication date: December 16, 2004Applicant: PALO ALTO RESEARCH CENTER INCORPORATEDInventors: Meng H. Lean, Huangpin Ben Hsieh, John S. Fitch, Armin R. Volkel, Bryan Preas, Scott Elrod, Richard H. Bruce, Eric Peeters, Frank Torres, Michael Chabinyc