Patents by Inventor Huangshu Lei

Huangshu Lei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL FORM I OF CANAGLIFLOZIN AND PREPARATION METHOD THEREOF
    Publication number: 20170342061
    Abstract: Disclosed in the present invention is a crystal form I of Canagliflozin, and an X-ray powder diffraction spectrum of the crystal form I has characteristic diffraction peaks when 2? is at the position of 4.4±0.2°, 8.4±0.2°, 16.8±0.2°, 17.5±0.2°, 18.0±0.2°, and 22.8±0.2°. The crystal form is physically and chemically stable and is suitable for manufacturing of various preparations.
    Type: Application
    Filed: March 27, 2015
    Publication date: November 30, 2017
    Applicant: CHONGQING PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE CO., LTD
    Inventors: Fei WANG, Jian ZHANG, Meng LIN, Yuanfu TANG, Hao CHEN, Huangshu LEI
  • 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
    Patent number: 8957068
    Abstract: The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: February 17, 2015
    Assignee: Novartis AG
    Inventors: Thomas Raymond Caferro, Young Shin Cho, Abran Q. Costales, Huangshu Lei, Francois Lenoir, Julian Roy Levell, Gang Liu, Mark G. Palermo, Keith Bruce Pfister, Martin Sendzik, Cynthia Shafer, Michael David Shultz, Troy Smith, James Clifford Sutton, Bakary-Barry Toure, Fan Yang, Qian Zhao
  • 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
    Publication number: 20140235620
    Abstract: The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
    Type: Application
    Filed: September 26, 2012
    Publication date: August 21, 2014
    Applicant: NOVARTIS AG
    Inventors: Thomas Raymond Caferro, Young Shin Cho, Abran Q. Costales, Huangshu Lei, Francois Lenoir, Julian Roy Levell, Gang Liu, Mark G. Palermo, Keith Bruce Pfister, Martin Sendzik, Cynthia Shafer, Michael David Shultz, Troy Smith, James Clifford Sutton, Bakary-Barry Toure, Fan Yang, Qian Zhao
  • (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses
    Patent number: 8552003
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: October 8, 2013
    Assignee: Novartis AG
    Inventors: Mark G. Charest, Christine Hiu-Tung Chen, Zhuoliang Chen, Miao Dai, Feng He, Huangshu Lei, Ly Luu Pham, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming David Wang, Fan Yang, Leigh Zawel
  • SMAC peptidometics useful as IAP inhibitors
    Patent number: 8546336
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 1, 2013
    Assignee: Novartis AG
    Inventors: Zhuoliang Chen, Mark G. Charest, Christine Hiu-Tung Chen, Miao Dai, Feng He, Huangshu Lei, Ly Luu Pham, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming David Wang, Fan Yang, Leigh Zawel
  • SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS
    Publication number: 20130005663
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: NOVARTIS AG
    Inventors: Mark G. CHAREST, Christine Hiu-Tung CHEN, Zhuoliang CHEN, Miao DAI, Feng HE, Huangshu LEI, Ly Luu PHAM, Sushil Kumar SHARMA, Christopher Sean STRAUB, Run-Ming David WANG, Fan YANG, Leigh ZAWEL
  • Pyrrolydine derivatives as IAP inhibitors
    Patent number: 8044209
    Abstract: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: October 25, 2011
    Assignee: Novartis AG
    Inventors: Mark G. Charest, Christine Hiu-Tung Chen, Ming Chen, Zhuoliang Chen, Miao Dai, Feng He, Huangshu Lei, Christopher Sean Straub, Run-Ming David Wang, Leigh Zawel
  • 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer
    Patent number: 7981903
    Abstract: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: July 19, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Stanley Dawes Chamberlain, Felix Deanda, Jr., Roseanne Gerding, Masaichi Hasegawa, Kevin Kuntz, Huangshu Lei, Yasushi Miyazaki, Naohiko Nishigaki, Samarjit Patnaik, Aniko Redman, John Brad Shotwell, Kirk Stevens, Joseph Wilson, Bin Yang
  • Organic Compounds
    Publication number: 20110065726
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Application
    Filed: July 31, 2007
    Publication date: March 17, 2011
    Inventors: Zhuoliang CHEN, Sushil Kumar Sharma, Christopher Straub, Mark G. Charest, Feng He, Run-Ming David Wang, Leigh Zawel, Christine Hiu-Tung Chen, Miao Dai, Huangshu Lei, Ly Pham, Fan Yang
  • Pyrrolydine Derivatives as IAP Inhibitors
    Publication number: 20110015232
    Abstract: The present invention relates to novel IAP inhibitor compounds of: Formula (I).
    Type: Application
    Filed: October 10, 2007
    Publication date: January 20, 2011
    Inventors: Mark G. Charest, Christine Hiu-Tung CHEN, Ming Chen, Zhuoliang Chen, Miao Dai, Feng He, Huangshu Lei, Christopher Straub, Run-Ming David Wang, Leigh Zawel
  • 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer
    Publication number: 20100204196
    Abstract: Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
    Type: Application
    Filed: August 6, 2008
    Publication date: August 12, 2010
    Inventors: Stanley Dawes Chamberlain, Felix Deanda, JR., Roseanne Gerding, Masaichi Hasegawa, Kevin Kuntz, Huangshu Lei, Yasushi Miyazaki, Naohiko Nishigaki, Samarjit Patnaik, Aniko Redman, John Brad Shotwell, Kirk Stevens, Joseph Wilson, Bin Yang
  • Androgen modulators
    Patent number: 7670613
    Abstract: The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: March 2, 2010
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Bruce A. Lefker, Daniel Y. Du, Yvonne Dorothy Smith, Huangshu Lei, William Glen Harter, Victoria Leigh Downs, Mark L. Boys, Donna Michele Iula
  • ANDROGEN MODULATORS
    Publication number: 20100048517
    Abstract: The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: November 5, 2009
    Publication date: February 25, 2010
    Inventors: Lain-Yen Hu, Bruce A. Lefker, Daniel Y. Du, Yvonne Dorothy Smith, Huangshu Lei, William Glen Harter, Victoria Leigh Downs, Mark L. Boys, Donna Michele Iula
  • Androgen receptor modulators
    Patent number: 7576128
    Abstract: The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: August 18, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
  • ANDROGEN MODULATORS
    Publication number: 20090192202
    Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: February 9, 2009
    Publication date: July 30, 2009
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker, Yvonne Dorothy Smith, Victor Fedij
  • ANDROGEN MODULATORS
    Publication number: 20090105349
    Abstract: The present invention is directed to the discovery of a new class of androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease sebum secretion and to stimulate hair growth.
    Type: Application
    Filed: August 8, 2005
    Publication date: April 23, 2009
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: Nicole Chantel Barvian, Daniel Yunlong Du, Lain-Yen Hu, Donna Michele Iula, Bruce Allen Lefker, Huangshu Lei, Raj Kumar Raheja, Yvonne Dorothy Smith
  • Androgen modulators
    Patent number: 7507860
    Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: March 24, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker, Yvonne Dorothy Smith, Victor Fedij
  • Androgen modulators
    Patent number: 7473711
    Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
  • Androgen modulators
    Publication number: 20070197641
    Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: April 1, 2005
    Publication date: August 23, 2007
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Du, Bruce Lefker, Yvonne Smith, Victor Fedij
  • Androgen modulators
    Publication number: 20070197642
    Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: April 15, 2005
    Publication date: August 23, 2007
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Du, Bruce Lefker