Abstract: Provided herein is 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol, which is a compound represented by formula I, or an enantiomer or a raceme thereof. The 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol is prepared with a 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-dicarbaldehyde derivative as a starting material through a Baeyer-Villiger oxidation rearrangement reaction and an alkaline hydrolysis reaction. The 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol comprises two gem-dimethyl groups and is a key intermediate for preparing corresponding 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based monophosphine ligands, such as phosphonite ligands, phosphite ligands, phosphoramidite ester ligands, phosphoric acid and phsophonamidate. The 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol skeleton provided herein could be used in chemical industry and has economic practicality and industrial application prospects.

Abstract: Provided are a 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based monophosphine ligand and intermediates thereof, and preparation methods and uses of the same. The monophosphine ligand is a compound represented by formula I or formula I?, or an enantiomer, a raceme or a diastereoisomer thereof, including phosphonite ligands, phosphite ligands, phosphoramidite ester ligands, phosphoric acid and phosphonic amide. The monophosphine ligand is prepared with a known 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol derivative as a raw material through a scheme in which the compound presented by formula II acts as an intermediate.

Abstract: Provided are a 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based monophosphine ligand and intermediates thereof, and preparation methods and uses of the same. The monophosphine ligand is a compound represented by formula I or formula I?, or an enantiomer, a raceme or a diastereoisomer thereof, including phosphonite ligands, phosphite ligands, phosphoramidite ester ligands, phosphoric acid and phosphonic amide. The monophosphine ligand is prepared with a known 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-7,7?-diol derivative as a raw material through a scheme in which the compound presented by formula II acts as an intermediate.