Patents by Inventor Huashi Zhang

Huashi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210259598
    Abstract: A working electrode for a subcutaneous sensor for use with a continuous biological monitor for a patient is disclosed. The working electrode includes a conductive substrate and an enzyme layer on the conductive substrate. The enzyme layer includes an enzyme, and the enzyme selected according to a biological function to be monitored. A hydrophobic material cross-linked with an acrylic polyol is included. The enzyme is fully entrapped in the cross-linked hydrophobic material with the acrylic polyol.
    Type: Application
    Filed: May 13, 2021
    Publication date: August 26, 2021
    Applicant: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Patent number: 11013438
    Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme is added to the base emulsion, which is applied to the working electrode and cured. Optionally, other additives can be added to the base emulsion prior to application, such as hydrophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 25, 2021
    Assignee: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Publication number: 20190357826
    Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring, Huashi Zhang, Mark Wu, David Sze
  • Publication number: 20190310218
    Abstract: Briefly, a sensor for a continuous biological monitor is provided for measuring the level of a target analyte for a patient. The sensor has a working wire and a reference wire, where the working wire has an analyte limiting layer that passes more than 1 in 1000 analyte molecules from the patient to the an enzyme layer . The enzyme layer has an enzyme entrapped in a polyurethane cross-linked with acrylic polyol. As free electrons are generated, a conductor transfers the electrons to the biological monitor. In some cases, the sensor may be constructed without the use of any expensive platinum.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 10, 2019
    Applicant: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Publication number: 20190307371
    Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Robert Boock, Jeff Jackson, Huashi Zhang, Jason Mitchell
  • Publication number: 20190307379
    Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with a new interfere layer that is (1) non-electron conducting, (2) ion passing, and (3) permselective for molecular weight. The new interference layer is made by mixing a monomer and a mildly basic buffer, and then electropolymerizing the monomer and the buffer into a polymer. The polymer is deposited onto a working electrode for a continuous metabolic monitor, for example, using an electro depositing process in the form of cyclic voltammety (CV). The interference layer is permselectable for molecule size by adjusting the pH of the basic buffer.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 10, 2019
    Applicant: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Publication number: 20190310220
    Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme is added to the base emulsion, which is applied to the working electrode and cured. Optionally, other additives can be added to the base emulsion prior to application, such as hydrophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 10, 2019
    Applicant: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Publication number: 20190307375
    Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced carbon-enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme and carbon materials are added to the base emulsion, which is applied to the working electrode and cured. The carbon materials may include carbon and graphite to provide strength, as well as graphene or pyrolytic graphite to provide a desirable electrical resistance for the carbon-enzyme layer. Optionally, other additives can be added to the base emulsion prior to application, such as hydophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 10, 2019
    Applicant: Zense-Life Inc.
    Inventors: Robert James Boock, Huashi Zhang
  • Patent number: 10413227
    Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: September 17, 2019
    Assignee: DexCom, Inc.
    Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring, Huashi Zhang, Mark Wu, David Sze
  • Publication number: 20190069826
    Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
    Type: Application
    Filed: October 31, 2018
    Publication date: March 7, 2019
    Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
  • Patent number: 10143410
    Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: December 4, 2018
    Assignee: DexCom, Inc.
    Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
  • Publication number: 20170319111
    Abstract: In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 9, 2017
    Inventors: Peter C. Simpson, Sebastian Bohm, Robert J. Boock, Matthew D. Wightlin, Huashi Zhang
  • Publication number: 20170311859
    Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring, Huashi Zhang, Mark Wu, David Sze
  • Publication number: 20170265795
    Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
  • Patent number: 9743871
    Abstract: In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: August 29, 2017
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Sebastian Bohm, Robert J. Boock, Matthew D. Wightlin, Huashi Zhang
  • Patent number: 9737250
    Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 22, 2017
    Assignee: DexCom, Inc.
    Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring, Huashi Zhang, Mark Wu, David Sze
  • Publication number: 20170188923
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
    Type: Application
    Filed: December 29, 2016
    Publication date: July 6, 2017
    Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
  • Publication number: 20170191955
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
    Type: Application
    Filed: December 29, 2016
    Publication date: July 6, 2017
    Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
  • Publication number: 20170188916
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.
    Type: Application
    Filed: December 30, 2016
    Publication date: July 6, 2017
    Inventors: Shanger Wang, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A Tapsak, Huashi Zhang, Jiong Zou
  • Patent number: 9693721
    Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 4, 2017
    Assignee: DexCom, Inc.
    Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence