Patents by Inventor Huaxiang YE

Huaxiang YE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for continuously preparing citalopram diol
    Patent number: 11845710
    Abstract: The present application relates to a method for citalopram intermediate citalopram diol. The method comprises: first mixing two Grignard reagents required for a reaction; then mixing the mixed Grignard reagents with a raw material 5-cyanophthalide in a temperature-controllable micromixer to obtain a reaction solution; then subjecting the reaction solution to the reaction by means of a reactor to obtain a citalopram diol reaction solution; and then performing operations such as quenching, concentration, extraction, acidification, and crystallization to obtain a qualified product. The citalopram diol provided in the present invention has good selectivity, high yield, high safety, safety and reliability, and little sewage discharge, and is suitable for industrial production.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: December 19, 2023
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, SHANGHAI AOBO PHARMTECH, INC., LTD.
    Inventors: Chen Liu, Xing Li, Huaxiang Ye, Jicheng Zhang, Luning Huang, Anping Tao, Jianguo An, Hong Gu
  • METHOD FOR CONTINUOUSLY PREPARING CITALOPRAM DIOL
    Publication number: 20220024860
    Abstract: The present application relates to a method for citalopram intermediate citalopram diol. The method comprises: first mixing two Grignard reagents required for a reaction; then mixing the mixed Grignard reagents with a raw material 5-cyanophthalide in a temperature-controllable micromixer to obtain a reaction solution; then subjecting the reaction solution to the reaction by means of a reactor to obtain a citalopram diol reaction solution; and then performing operations such as quenching, concentration, extraction, acidification, and crystallization to obtain a qualified product. The citalopram diol provided in the present invention has good selectivity, high yield, high safety, safety and reliability, and little sewage discharge, and is suitable for industrial production.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 27, 2022
    Inventors: Chen LIU, Xing LI, Huaxiang YE, Jicheng ZHANG, Luning HUANG, Anping TAO, Jianguo AN, Hong GU