Abstract: A sealed container especially adapted for medical usage to receive and dispense fluids without contamination has a two orifice closure system whereby contaminants are kept out by a microfilter when an inlet orifice is opened for additions, and by a valve when an outlet orifice is opened for withdrawals. The closure has an upper removable seal and a lower fixed seal spaced from the upper removable seal and cooperating therewith in defining an operative space compartment sealed from both the interior of the container and the outside. In some embodiments, the lower seal has inlet and outlet passageways joining the interior of the container with the operative space compartment. An independent seal accessible from the operative space compartment is provided for the inlet passageway which is associated with the microfilter for stopping ingress of contaminants into the container. The valve provided at the outlet passageway is accessible from the operative space compartment to control outflow.