Patents by Inventor Hubert A. Nicholson
Hubert A. Nicholson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150080418Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: ApplicationFiled: November 21, 2014Publication date: March 19, 2015Inventors: Ivan Leo PINTO, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Patent number: 8536183Abstract: The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: GrantFiled: August 7, 2012Date of Patent: September 17, 2013Assignee: Convergence Pharmaceuticals LimitedInventors: Paul John Beswick, Alister Campbell, Andrew Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Patent number: 8530478Abstract: The present invention relates to novel piperazine derivatives (I); to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: GrantFiled: July 15, 2009Date of Patent: September 10, 2013Assignee: Convergence Pharmaceuticals LimitedInventors: Paul John Beswick, Alister Campbell, Andrew Peter Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Publication number: 20130150383Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: ApplicationFiled: February 6, 2013Publication date: June 13, 2013Applicant: GlaxoSmithKline LLCInventors: Ivan Leo PINTO, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Patent number: 8394808Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: GrantFiled: September 2, 2009Date of Patent: March 12, 2013Assignee: Glaxosmithkline LLCInventors: Ivan Leo Pinto, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Publication number: 20120302746Abstract: The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: ApplicationFiled: August 7, 2012Publication date: November 29, 2012Inventors: Paul John Beswick, Alister Campbell, Andrew Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Patent number: 8288388Abstract: The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: GrantFiled: July 15, 2009Date of Patent: October 16, 2012Assignee: Convergence Pharmaceuticals LimitedInventors: Paul John Beswick, Alister Campbell, Andrew Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Patent number: 8268839Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: GrantFiled: March 4, 2010Date of Patent: September 18, 2012Assignee: Glaxosmithkline LLCInventors: Ivan Leo Pinto, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Publication number: 20110130379Abstract: The present invention relates to novel piperazine derivatives (I); to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: ApplicationFiled: July 15, 2009Publication date: June 2, 2011Applicant: CONVERGENCE PHARMACEUTICALS LIMITEDInventors: Paul John Beswick, Alister Campbell, Andrew Peter Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Publication number: 20100160354Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: ApplicationFiled: March 4, 2010Publication date: June 24, 2010Inventors: Ivan Leo Pinto, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Publication number: 20100022555Abstract: The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.Type: ApplicationFiled: July 15, 2009Publication date: January 28, 2010Inventors: Paul John Beswick, Alister Campbell, Andrew Cridland, Robert James Gleave, Jag Paul Heer, Neville Hubert Nicholson, Lee William Page, Sadie Vile
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Publication number: 20100010021Abstract: The present invention relates to therapeutically active xanthine derivative compounds of Formula (I): corresponding processes for manufacture of said derivatives, pharmaceutical formulations containing and uses of such compounds in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.Type: ApplicationFiled: September 2, 2009Publication date: January 14, 2010Inventors: Ivan Leo Pinto, Shahzad Sharooq Rahman, Neville Hubert Nicholson
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Patent number: 6692950Abstract: A compound of formula (I), wherein R=H or Na, or a salt thereof and an enzyme, obtainable from Streptomyces species, having clavulanic acid dehydrogenase activity which is capable of converting (I) into clavulanic acid.Type: GrantFiled: April 3, 1996Date of Patent: February 17, 2004Assignee: SmithKline Beecham plcInventors: Stephen William Elson, Neville Hubert Nicholson, Stefan Roland Woroniecki, Janice Arnell
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Publication number: 20030219867Abstract: An isolated DNA fragment encoding a protein with CAD activity wherein the protein is clavulanic acid dehydrogenase (CAD) from S. clavuligerus, with the proviso that the isolated DNA fragment is not: (a) the 13.1 kb BglII to SphI fragment of S. clavuligerus; (b) the 10.8 kb EcoRI to BamHI fragment of S. clavuligerus; (c) the 8.8 kb BclI to BclII fragment of S. clavuligerus; (d) the 2.5 kb BglII to BglII fragment of S. clavuligerus; (e) the 60 kb BglII to BamHI fragment of S. clavuligerus; or (f) the 18.0 BclI to SphI fragment of S. clavuligerus.Type: ApplicationFiled: February 14, 2003Publication date: November 27, 2003Applicant: SmithKline Beecham plcInventors: Janice Arnell, Stephen William Elson, Neville Hubert Nicholson, Stefan Roland Woroniecki
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Publication number: 20010007743Abstract: A method of identifying compounds which interact, directly or indirectly, with a target molecule of interest, wherein the target molecule of interest is an RNA, comprises screening compounds for interaction with the (L)-enantiomer of the said RNA, and identifying, as hits, the enantiomers of those compounds for which a said interaction is detected.Type: ApplicationFiled: May 26, 1999Publication date: July 12, 2001Inventors: DAVID JUSTIN CHARLES KNOWLES, BRIAN METCALF, NEVILLE HUBERT NICHOLSON, NEIL DAVID PEARSON, CATHERINE DENISE PRESCOTT
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Patent number: 5869299Abstract: A process for preparing clavulanic acid and other clavam derivatives using an enzyme system from Streptomyces, particularly S. Clavuligerus.Type: GrantFiled: August 25, 1995Date of Patent: February 9, 1999Assignee: SmithKline Beecham p.l.c.Inventors: Keith Howard Baggaley, Neville Hubert Nicholson, Stephen William Elson, Jeffrey Edwards, Alison Jane Earl, William Henry Holms, David Michael Mousdale, Jack Edward Baldwin, Christopher Schofield
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Patent number: 5665717Abstract: Carbacephalosporin compounds of formula (I), ##STR1## salts thereof, processes for their synthesis and uses thereof, wherein: R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 represent hydrogen or a substituent; R.sup.4 and R.sup.7 may be replaced by a chemical bond between the two carbon atoms shown; R.sup.5 and R.sup.6 may be linked together into a cyclic system. The compounds (I) have antibacterial properties.Type: GrantFiled: January 18, 1996Date of Patent: September 9, 1997Assignee: Pfizer Inc.Inventors: Richard Leonard Elliott, Neville Hubert Nicholson, Andrew Kenneth Takle
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Patent number: PP6305Abstract: There is disclosed a variegated leaved red flowering Dogwood tree having purplish red blooms with distinct pinkish-red tipped new growth, olive green and yellow summer foliage with colorful fall foliage ranging from pink through red to purple.Type: GrantFiled: October 28, 1986Date of Patent: September 27, 1988Assignee: Commercial Nursery, Inc.Inventor: Hubert A. Nicholson
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Patent number: PP6320Abstract: A white flowering Dogwood having distinct olive green leaves with a yellow white margin and fall foliage of distinct color which is borne on an unusually vigorous tree that is more resistant to anthracnose than other variegated leaf dogwood trees.Type: GrantFiled: October 28, 1986Date of Patent: October 4, 1988Assignee: Commercial Nursery, Inc.Inventor: Hubert A. Nicholson
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Patent number: PP10166Abstract: A distinctive Dogwood cultivar of the Cornus florida genus and species having bracts which present an overall strong red appearance with white portions at the base of the bracts and white apical notches, the plant being vigorous and with distinct purplish red new growth, and resistance to powdery mildew.Type: GrantFiled: December 18, 1995Date of Patent: December 30, 1997Assignee: Commercial Nursery Co., Inc.Inventor: Hubert A. Nicholson, deceased