Patents by Inventor Hubert C. Chen

Hubert C. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified mouse lacking diacylglycerol acyltransferase-1 (DGAT-1) activity
    Patent number: 7745691
    Abstract: Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: June 29, 2010
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs, The J. David Gladstone Institutes
    Inventors: Robert V. Farese, Jr., Hubert C. Chen, Steven J. Smith, Sylvaine Cases, Sandra K. Erickson
  • Methods and compositions for modulating carbohydrate metabolism
    Publication number: 20030154504
    Abstract: Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
    Type: Application
    Filed: November 5, 2002
    Publication date: August 14, 2003
    Inventors: Robert V. Farese, Hubert C. Chen
  • Methods and compositions for modulating sebaceous glands
    Publication number: 20030100480
    Abstract: Methods and compositions for modulating sebaceous gland activity in a host are provided. In the subject methods, DGAT1 activity is modified, e.g., reduced or enhanced, to achieve the desired sebaceous gland activity modulation, e.g., reduction in sebum production and/or sebaceous gland size. Also provided are pharmaceutical preparations for use in practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering from sebaceous gland related conditions, e.g., acne and related conditions.
    Type: Application
    Filed: October 21, 2002
    Publication date: May 29, 2003
    Inventors: Steven J. Smith, Hubert C. Chen, Robert V. Farese