Patents by Inventor Hubert E. Blum

Hubert E. Blum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition for treating hepatitis B virus (HBV) infection
    Patent number: 6410009
    Abstract: The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the binding sites between hIL6 and pS1 and between hIL6 and hepatocytes and other HBV-permissive cells, the active agent being present in sufficient amount to competitively bind to at least one of the sites and thereby to prevent hIL6-mediated HBV infection of hepatocytes and other HBV-permissive cells.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: June 25, 2002
    Assignee: Hadasit Medical Research Services & Development Co., Ltd.
    Inventors: Eithan Galun, Orit Nahor, Hubert E. Blum
  • Pharmaceutical composition for treating hepatitis B virus (HBV) infection
    Patent number: 6217858
    Abstract: The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the binding sites between hIL6 and pS1 and between hIL6 and hepatocytes and other HBV-permissive cells, the active agent being present in sufficient amount to competitively bind to at least one of the sites and thereby to prevent hIL6-mediated HBV infection of hepatocytes and other HBV-permissive cells.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: April 17, 2001
    Assignee: Hadasit & Medical Research Services & Development Company, Ltd.
    Inventors: Eithan Galun, Orit Nahor, Hubert E. Blum
  • Methods of preventing viral replication
    Patent number: 5610050
    Abstract: The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: March 11, 1997
    Assignee: The General Hospital Corporation
    Inventors: Hubert E. Blum, Tsanyang Liang, Eithan Galun, Jack R. Wands