Patents by Inventor Hubert Gaertner
Hubert Gaertner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10087234Abstract: The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.Type: GrantFiled: November 6, 2013Date of Patent: October 2, 2018Assignees: LES HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITE DE GENEVE, HOFFMAN-LA ROCHE INC.Inventors: Nicolas Vuilleumier, Sabrina Pagano, Oliver Hartley, Hubert Gaertner, Priscila Camillo Teixeira, Paul Cutler, Philippe Ferber
-
Patent number: 9198974Abstract: The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications. Such applications include drag and gene delivery, tumour targeting, bioimaging, tissue remodelling, generation of antiviral products and vaccines delivery.Type: GrantFiled: April 11, 2012Date of Patent: December 1, 2015Assignee: Mintaka Foundation for Medical ResearchInventors: Hubert Gaertner, Oliver Hartley
-
Publication number: 20150291682Abstract: The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.Type: ApplicationFiled: November 6, 2013Publication date: October 15, 2015Inventors: Nicolas VUILLEUMIER, Sabrina PAGANO, Oliver HARTLEY, Hubert GAERTNER, Priscila CAMILLO TEIXEIRA, Paul CUTLER, Philippe FERBER
-
Publication number: 20140221569Abstract: The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications. Such applications include drag and gene delivery, tumour targeting, bioimaging, tissue remodelling, generation of antiviral products and vaccines delivery.Type: ApplicationFiled: April 11, 2012Publication date: August 7, 2014Inventors: Hubert Gaertner, Oliver Hartley
-
Patent number: 7884182Abstract: The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal heterocyclic protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.Type: GrantFiled: November 14, 2002Date of Patent: February 8, 2011Assignee: Amylin Pharmaceuticals, Inc.Inventors: Paolo Botti, Hubert Gaertner, Sonia Manganiello, Matteo Villain
-
Patent number: 7781488Abstract: The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.Type: GrantFiled: June 9, 2003Date of Patent: August 24, 2010Assignee: Amylin Pharmaceuticals, Inc.Inventors: Paolo Botti, Matteo Villain, Sonia Manganiello, Hubert Gaertner
-
Patent number: 7662914Abstract: The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal cyclic thiazolidine protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.Type: GrantFiled: May 31, 2002Date of Patent: February 16, 2010Assignee: Amylin Pharmaceuticals, Inc.Inventors: Matteo Villain, Hubert Gaertner
-
Patent number: 7566697Abstract: The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.Type: GrantFiled: June 9, 2003Date of Patent: July 28, 2009Assignee: Amylin Pharmaceuticals, Inc.Inventors: Paolo Botti, Matteo Villain, Sonia Manganiello, Hubert Gaertner
-
Publication number: 20070059792Abstract: The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.Type: ApplicationFiled: June 9, 2003Publication date: March 15, 2007Inventors: Paolo Botti, Matteo Villain, Sonia Manganiello, Hubert Gaertner
-
Publication number: 20050261473Abstract: The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotecte acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters.Type: ApplicationFiled: June 9, 2003Publication date: November 24, 2005Applicant: GeneProt, Inc.Inventors: Paolo Botti, Matteo Villain, Sonia Manganiello, Hubert Gaertner
-
Publication number: 20050113563Abstract: The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal heterocyclic protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improve,s; the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.Type: ApplicationFiled: November 14, 2002Publication date: May 26, 2005Inventors: Paolo Botti, Hubert Gaertner, Sonia Manganiello, Matteo Villain
-
Publication number: 20050064538Abstract: The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal cyclic thiazolidine protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where three or more peptide fragements are used to assemble a polypeptide or protein product.Type: ApplicationFiled: May 31, 2002Publication date: March 24, 2005Inventors: Matteo Villain, Hubert Gaertner
-
Publication number: 20040077835Abstract: Chemokine receptor modulators comprising a chemically modified carboxyl-terminus (C-terminus) and/or amino-terminus (N-terminus) for modulating potency and pharmacokinetic properties, and methods of production and use are disclosed. The compounds and methods of the invention are exemplified by novel N-terminal, C-terminal and N/C-terminal analogs of CC and CXC chemokines. The chemokine receptor modulator analogs of the invention are useful for the treatment of disorders involving the naturally occurring chemokine that the analogs of the invention antagonize, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.Type: ApplicationFiled: January 6, 2003Publication date: April 22, 2004Inventors: Robin Offord, Hubert Gaertner, Oliver Hartley
-
Patent number: 4701328Abstract: Polylysine and/or polymethionylpolylysine are advantageously incorporated in compositions for feeding animals, especially ruminants, to provide assimilable lysine and methionine.Type: GrantFiled: January 31, 1986Date of Patent: October 20, 1987Assignee: A.E.C. Societe de Chimie Organique et BiologiqueInventors: Daniel Bercovici, Hubert Gaertner, Antoine Puigserver