Patents by Inventor Hubert Graafland

Hubert Graafland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for separating and/or detecting and/or quantifying (an) infectious compound(s) and support for implementing the process
    Patent number: 6465191
    Abstract: Method for separating and/or screening and/or quantifying one or more infectious compounds (IC) in a biological material, characterised in that a &bgr;2GPLIC complex, chosen from the group comprising a) (&bgr;2GPI)n/IC complexes and b) (&bgr;2GPI)r/nVIC (non viral IC) complexes, is separated and/or screened and/or quantified.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: October 15, 2002
    Assignee: Institut Francais de Recherches Scientifiques Pour le Developpement en Cooperation-Orstom
    Inventors: Elie Stefas, Marcell Rucheton, Hubert Graafland, Francisco Veas
  • Aqueous .beta.2'-glycoprotein I composition
    Patent number: 5859213
    Abstract: A method for preparing an aqueous protein composition from human blood plasma, wherein the plasma undergoes a series of treatments by heating and precipitating agent to give albumin solutions containing the precipitating agent, and said precipitating agent is separated from the resulting solutions to give a crude aqueous albumin solution which is subjected to at least one liquid phase chromatography step to retain at least part of the secondary proteins other than albumin. The chromatography comprises affinity chromatography on a particulate support consisting of neutral particles loaded with at least one compound comprising sulphate groups, whereby, after the albumin solution has been fed through, the particulate affinity chromatography support is eluted by feeding through an aqueous saline solution, preferably by increasing the ionic strength, and the desired protein composition is collected by elution.
    Type: Grant
    Filed: October 23, 1995
    Date of Patent: January 12, 1999
    Inventors: Elie Stefas, Marcel Rucheton, Hubert Graafland
  • Method for purifying an aqueous solution of raw albumin
    Patent number: 5677424
    Abstract: Method for purifying an aqueous solution of raw albumin wherein contaminant proteins are bound by chromatography to a stationary solid phase, preferably a particulate phase, the purified albumin solution being collected as an effluent, in which a neutral phase charged with at least one compound chosen from the group formed by compounds containing C.sub.3 to C.sub.8 alkyl radicals and compounds containing sulfate groups is used as the stationary phase.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: October 14, 1997
    Inventors: Marcel Rucheton, Elie Stefas, Hubert Graafland
  • Method for detecting viral compounds using a .beta.2'-glycoprotein I
    Patent number: 5650269
    Abstract: A method for detecting and/or assaying viral compounds, wherein the viral compounds are bound with .beta.2'-glycoprotein I which is a glycoprotein having a molecular weight of 50,000.+-.3,000 daltons from the method for producing albumin obtained as a blood plasma by-product according to FR-A 2 690 444. Viral compound separation may be simplified by binding the .beta.2'-glycoprotein I to a preferably solid support or by binding the viral compounds to a support and exposing same with the .beta.2'-glycoprotein I conjugated with a marker. A solid support to which at least the .beta.2'-glycoprotein I is bound, is also disclosed.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: July 22, 1997
    Inventors: Marcel Rucheton, Elie Stefas, Hubert Graafland