Patents by Inventor Hubert Serve

Hubert Serve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPANION DIAGNOSTICS FOR LEUKEMIA TREATMENT
    Publication number: 20200032350
    Abstract: The present invention pertains to a method for detecting whether a cancer disease in a subject is susceptible to a treatment with a Spleen Tyrosine Kinase (SYK) inhibitor by determining the amount or level of a biomarker selected from Hoxa9/Meis1, PU.1 and miR146a in a biological sample from the subject. The invention provides novel treatment approaches based on the detection of the differential expression of the above biomarkers using SYK inhibitors. Also provided are diagnostic kits, and combined therapeutic and diagnostic kits for use in the inventive methods.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 30, 2020
    Inventors: THOMAS OELLERICH, HUBERT SERVE, SEBASTIAN MOHR, CARMEN DÖBELE
  • SAMHD1 MODULATION FOR TREATING RESISTANCE TO CANCER THERAPY
    Publication number: 20180313843
    Abstract: The present invention pertains to novel treatments for cancer diseases. Treatment of cancers with nucleoside analogs (NA), which specifically inhibit rapidly dividing cells, may face preexisting NA resistance or development of resistant cancer cells resulting in poor clinical prognosis. Treatment of cancers with oncolytic herpes simplex viruses (HSV) may face preexisting resistance or development of resistant cancer cells resulting in poor clinical prognosis. The invention overcomes chemotherapy resistance or resistance to oncolytic HSV by providing methods for detecting the resistance in a cancer disease based on the expression of SAM domain and HD domain-containing protein 1 (SAMHD1) in cancer cells. Furthermore provided are treatment options addressing the chemotherapy resistance such as a combination of a SAMHD1 inhibitor with a NA. Moreover, provided are treatment options addressing the resistance to oncolytic HSV such as a combination of a SAMHD1 inhibitor or depletion of SAMHD1 with an oncolytic HSV.
    Type: Application
    Filed: November 2, 2016
    Publication date: November 1, 2018
    Inventors: Oliver Till KEPPLER, Jindrich CINATL, Constanze SCHNEIDER, Hanna-Mari BALDAUF, Sarah-Marie SCHWARZ, Hubert SERVE, Thomas OELLERICH, Gerd GEISSLINGER, Veit HORNUNG
  • Delocalization molecules and use thereof
    Patent number: 8362205
    Abstract: The invention relates to delocalization molecules, methods for the production thereof, and the use thereof as medicaments, especially for treating tumors.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: January 29, 2013
    Assignees: Oncoscience AG
    Inventors: Wolfgang Berdel, Carsten Müller-Tidow, Hubert Serve, Björn Steffen
  • Delocalization molecules and use thereof
    Publication number: 20060166876
    Abstract: The invention relates to delocalization molecules, methods for the production thereof, and the use thereof as medicaments, especially for treating tumors.
    Type: Application
    Filed: October 17, 2003
    Publication date: July 27, 2006
    Inventors: Wolfgang Berdel, Carsten Muller-Tidow, Hubert Serve, Bjorn Steffen