Patents by Inventor Hubert Simons
Hubert Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140249050Abstract: Disclosed is a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step. Also disclosed is an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscope or labelling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers.Type: ApplicationFiled: May 16, 2014Publication date: September 4, 2014Applicant: BIOCARTIS SAInventors: Marc Jan René LEBLANS, Emmanuel Marie Paul Ernest GUSTIN, Christiaan Hubert Simon ROELANT, Stefaan Cornelis DE SMEDT, Joseph DEMEESTER, Kevin BRAECKMANS
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Publication number: 20140206569Abstract: Encoded microcarriers, and more specifically microcarriers having codes written on them. Methods for writing the codes on the microcarriers, methods of reading the codes, and methods of using the encoded microcarriers. A preferred method of encoding the microcarriers involves exposing microcarriers containing a bleachable substance to a high spatial resolution light source to bleach the codes on the microcarriers. The encoded microcarriers may be used, for example, as support materials in chemical and biological assays and syntheses.Type: ApplicationFiled: March 25, 2014Publication date: July 24, 2014Applicant: Biocartis SAInventors: Stefaan Cornelis De Smedt, Joseph Demeester, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels
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Patent number: 8735172Abstract: The present invention relates to a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step, wherein the identification purpose step is a detection step for the detection of an encoded microcarrier having an anisotropy in its shape. The invention further relates to an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscope and means for the positioning and orientation of the microcarriers.Type: GrantFiled: September 22, 2010Date of Patent: May 27, 2014Assignee: Biocartis S.A.Inventors: Marc Jan René Leblans, Emmanuel Marie Paul Ernest Gustin, Christiaan Hubert Simon Roelant, Joseph Demeester, Stefaan Cornelis De Smedt, Kevin Braeckmans
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Publication number: 20110082046Abstract: The present invention relates to a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step, wherein the identification purpose step is a detection step for the detection of an encoded microcarrier having an anisotropy in its shape. The invention further relates to an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscoper and means for the positioning and orientation of the microcarriers.Type: ApplicationFiled: September 22, 2010Publication date: April 7, 2011Applicant: Universiteit GentInventors: Marc Jan René LEBLANS, Emmanuel Marie Paul Ernest Gustin, Christiaan Hubert Simon Roelant, Stefaan Cornelis De Smedt, Joseph Demeester, Kevin Braeckmans
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Patent number: 7045312Abstract: The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound to a protein or tissue or introduced into a cell. The invention also relates to methods of utilizing the apo metal binding protein for detecting a cell expressing a protein of interest, localizing a protein in a cell, and designing a therapeutic agent for treating a disease or infection.Type: GrantFiled: September 8, 2004Date of Patent: May 16, 2006Inventors: Inge Dierynck, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels, Koenraad Lodewijk August Van Acker, Jan Octaaf Antoon De Kerpel
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Patent number: 6868875Abstract: A method for dispensing a volume of fluids from a reservoir, through a fluid outlet in fluid communication with said reservoir, into each well of at least a series of wells, whereby the fluid is dispensed into said series of wells at a continuous uninterrupted flow. A micro titer plate constructed from a hydrophobic and more in particular from a plastic material containing a plurality of series of wells and to an apparatus able to perform the above method.Type: GrantFiled: March 8, 2001Date of Patent: March 22, 2005Assignee: Tibotec BVBAInventors: Werner René Irène De Beukeleer, Christiaan Hubert Simon Roelant
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Patent number: 6800437Abstract: The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound to a protein or tissue or introduced into a cell. The invention also relates to methods of utilizing the apo metal binding protein for detecting a cell expressing a protein of interest, localizing a protein in a cell, and designing a therapeutic agent for treating a disease or infection.Type: GrantFiled: August 4, 2000Date of Patent: October 5, 2004Assignee: Tibotec BvbaInventors: Inge Dierynck, Christiaan Hubert Simon Roelant, Rudi Wilfried Jan Pauwels, Koenraad Lodewijk August Van Acker, Jan Octaaf Antoon De Kerpel
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Publication number: 20040069857Abstract: The present invention relates to a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier, and (b) a positioning and orientation step prior to or during the identification purpose step, wherein the identification purpose step is a detection step for the detection of a identifiable or encoded microcarrier and a labeling step resulting in a identifiable or encoded microcarrier. The invention further relates to an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscope or labeling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers and to a microcarrier suitable for use in a method according to the invention.Type: ApplicationFiled: April 16, 2003Publication date: April 15, 2004Inventors: Marc Jan Rene Leblans, Emmanuel Marie Paul Ernest Gustin, Christiaan Hubert Simon Leuven Roelant, Stefaan Cornelis Mariakerke De Smedt, Joseph De Meester, Kevin Braeckmans
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Publication number: 20030155034Abstract: The present invention relates to a method for dispensing a volume of fluids from a reservoir, through a fluid outlet in fluid communication with said reservoir, into each well of at least a series of wells, whereby the method comprises a dispensing mode and a non-dispensing mode, whereby the fluid is dispensed into said series of wells at a continuous uninterrupted flow.Type: ApplicationFiled: February 5, 2003Publication date: August 21, 2003Inventors: Werner Rene Irene De Beukeleer, Christiaan Hubert Simon Roelant
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Publication number: 20020081629Abstract: A method for the rapid screening of analytes, such as potential drug candidates, comprises the steps of applying a plurality of analytes to be screened onto one or more, solid support(s) (61) such that the analytes remain isolated from one another; contacting said analyte-carrying solid support(s) (61) with targets provided in a semi-solid or liquid medium, whereby said analytes are released from the solid support(s) (61) to the targets; and measuring analyte-target interactions. This method allows for the manipulation of thousands of different analytes simultaneously. When the analyte is applied to the solid support (61) it can diffuse thereon so as to produce a concentration gradient and serial dilution of analyte if a dose response curve for a candidate drug is required. The method described can be readily automated.Type: ApplicationFiled: December 19, 2001Publication date: June 27, 2002Applicant: TIBOTEC N.V.Inventors: Rudi Wilfried Jan Pauwels, Christiaan Hubert Simon Roelant, Koenraad Lodewijk August Van Acker
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Patent number: 5394805Abstract: The sabot (16) relates to a projectile (11) which can be accelerated in an accelerator comprising a tubular preaccelerator followed by RAM acceleration tubes. It consists of an outer band (18) which is designed in a way to be attached to the radial fins (13) at the rear of the projectile (11) and to support the peripheral sealing elements (25) and a subcaliber base plate (31) of relatively small thickness, which is designed in such a way that it rests on the outer band (18) with its perimeter, and if necessary on the projectile base (7) with its center part, and that it separates from the projectile (11) and the outer band (18) before the projectile (11) enters into the acceleration tubes.Type: GrantFiled: September 2, 1993Date of Patent: March 7, 1995Assignee: Institut Franco-Allemand de Recherches de Saint-LouisInventors: Marc Giraud, Hubert Simon
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Patent number: 5166383Abstract: Compounds of general formula I ##STR1## wherein R.sup.2 is hydrogen unsubstituted C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl substituted by --OH, --CN or by --Si(OR.sup.3).sub.3-q R.sup.4.sub.q, or C.sub.2 -C.sub.6 alkenyl,R.sup.3 is C.sub.1 -C.sub.4 alkyl, or two radicals R.sup.3 together are C.sub.1 -C.sub.4 alkylene,R.sup.4 is C.sub.1 -C.sub.4 alkyl or phenyl, andq is from 0 to 2, andE is a radical of the formula ##STR2## wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl andR.sup.6 is hydrogen, orR.sup.5 and R.sup.6 together are C.sub.4 -C.sub.8 alkylene, orandA is --(CH.sub.2).sub.r --O--, wherein r is 1,2 or 3, and p is 0 or 1, andY is oxygen or sulfur; andwhereinT is a radical --R.sup.9 --Si(OR.sup.3).sub.3-q R.sup.4.sub.q, a radical of the formula ##STR3## X is --S-- or --NH--, and Z is an organic radical derived from a polyisocyanate or polyisothiocyanate having at least 2 NCO or NCS groups, respectively,are suitable as adhesion promoters, especially for moisture-curing polyurethane resins.Type: GrantFiled: June 7, 1990Date of Patent: November 24, 1992Assignee: Ciba-Geigy CorporationInventors: Giovanni Parrinello, Hubert Simon, Rolf Mulhaupt
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Patent number: 5128423Abstract: Compounds of the general formula I ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or benzyl,R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl, orR.sub.1 and R.sub.2, together with the linking carbon atom, form a 5- or 6-membered ring, andR.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and are hydrogen, C.sub.1 -C.sub.12 alkyl, phenyl or phenyl substituted by 1 to 3 members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy or are a group of formula --CH.sub.2 OR.sub.11, where R.sub.11, where R.sub.11 is C.sub.1 -C.sub.12 alkyl, phenyl or phenyl substituted by 1 to 3 members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy, or are --C(O)--R.sub.12, and R.sub.12, and R.sub.12 is C.sub.1 -C.sub.12 alkyl,R.sub.7 is C.sub.1 -C.sub.4 alkylene, R.sub.8 is C.sub.1 -C.sub.8 alkylene, R.sub.9 is C.sub.1 -C.sub.4 alkyl, or two radicals R.sub.9 together are C.sub.Type: GrantFiled: June 17, 1991Date of Patent: July 7, 1992Assignee: Ciba-Geigy CorporationInventors: Giovanni Parrinello, Rolf Mulhaupt, Hubert Simon
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Patent number: 5047546Abstract: Compounds of the general formula I ##STR1## wherein R.sub.1 is a hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or benzy.,R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl, orR.sub.1 and R.sub.2, together with the linking carbon atom, form a 5- or 6-membered ring, andR.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and are hydrogen, C.sub.1 -C.sub.12 alkyl, phenyl or phenyl substituted by 1 to 3 members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy or are a group of formula --CH.sub.2 OR.sub.11, where R.sub.11 is C.sub.1 -C.sub.12 alkyl, phenyl or phenyl substituted by 1 to 3 members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy, or are --C(O)-R.sub.12, and R.sub.12 is C.sub.1 -C.sub.12 alkyl,R.sub.7 is C.sub.1 -C.sub.4 alkylene, R.sub.8 is C.sub.1 -C.sub.8 alkylene, R.sub.9 is C.sub.1 -C.sub.4 alkyl, or two radicals R.sub.9 together are C.sub.1 -C.sub.4 alkylene, and R.Type: GrantFiled: November 9, 1990Date of Patent: September 10, 1991Assignee: Ciba-Geigy CorporationInventors: Giovanni Parrinello, Rolf Mulhaupt, Hubert Simon
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Patent number: 4963636Abstract: Compounds of formula (I) ##STR1## wherein one of the radicals R.sup.1 or R.sup.2 is --N.dbd.C.dbd.O and the other is --NHC(O)S(CH.sub.2).sub.3 Si(OR.sup.3).sub.3, wherein R.sup.3 is C.sub.1 -C.sub.4 alkyl or phenyl, are most suitable for use as adhesion promoters for polyurethane single-component or two-component adhesives and also as primers.Type: GrantFiled: February 12, 1990Date of Patent: October 16, 1990Assignee: Ciba-Geigy CorporationInventors: Rolf Mulhaupt, Hubert Simon
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Patent number: 4908406Abstract: Curable mixtures, comprising(a) a cycloaliphatic polyol of the formula I ##STR1## in which z is ##STR2## m is a number from 2 to 5, n is zero or a number from 1 to 10 and X is a direct bond or an aliphatic or cycloaliphatic radical, and(b) a prepolymeric polyhydroxy compound blocked by an aliphatic or cycloaliphatic diisocyanate, are advantageously suitable for producing adhesive bonds and seals having high tensile shear strengths.Type: GrantFiled: December 27, 1988Date of Patent: March 13, 1990Assignee: Ciba-Geigy CorporationInventors: Rolf Mulhaupt, Hubert Simon, Jacques-Alain Cotting
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Patent number: 4874805Abstract: Compounds of the general formula I ##STR1## in which R.sup.1 is hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, phenyl or benzyl and R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl, or R.sup.1 and R.sup.2, together with the C atom to which they are attached, form a 5-membered or 6-membered ring, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are identical or different and are hydrogen, C.sub.1 -C.sub.12 -alkyl, phenyl which is unsubstituted or monosubstituted to trisubstituted by C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, or is a group of the formula --CH.sub.2 OR.sup.7 (II) in which R.sup.7 is C.sub.1- C.sub.12 -alkyl, phenyl which is unsubstituted or monosubstituted to trisubstituted by C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, or is --C(O)--R.sup.8, and R.sup.8 is C.sub.1 -C.sub.12 -alkyl, and also not more than two of the radicals R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are one or two groups of the formula --CH.sub.2 CH.sub.2 Si(OR.sup.9).sub.3 (III), --CH.Type: GrantFiled: June 29, 1988Date of Patent: October 17, 1989Assignee: Ciba-Geigy CorporationInventors: Rolf Mulhaupt, Hubert Simon
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Patent number: 4772716Abstract: Compounds of the general formula I ##STR1## in which R.sup.1 is hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, phenyl or benzyl and R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl, or R.sup.1 and R.sup.2, together with the C atom to which they are attached, form a 5-membered or 6-membered ring, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are identical or different and are hydrogen, C.sub.1 -C.sub.12 -alkyl, phenyl which is unsubstituted or monosubstituted to trisubstituted by C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, or is a group of the formula --CH.sub.2 OR.sup.7 (II) in which R.sup.7 is C.sub.1 -C.sub.12 -alkyl, phenyl which is unsubstituted or monosubstituted to trisubstituted by C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, or is --C(O)--R.sup.8, and R.sup.8 is C.sub.1 -C.sub.12 -alkyl, and also not more than two of the radicals R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are one or two groups of the formula --CH.sub.2 CH.sub.2 Si(OR.sup.9).sub.3 (III), --CH.Type: GrantFiled: July 6, 1987Date of Patent: September 20, 1988Assignee: Ciba-Geigy CorporationInventors: Rolf Mulhaupt, Hubert Simon
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Patent number: 4170688Abstract: The invention disclosed provides a new improved metallic support member and process for bonding the metallic support member to a glass surface by means of an intermediate vitreous coating.Type: GrantFiled: July 6, 1978Date of Patent: October 9, 1979Assignee: Saint-Gobain IndustriesInventors: Paul Roentgen, Hubert Simons, Werner Nuding
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Patent number: D392435Type: GrantFiled: May 1, 1995Date of Patent: March 24, 1998Assignee: General Mills, Inc.Inventors: Gerardus Johannes Mocking, Hubert Simon