Abstract: Herein is reported the use of a binding assay of a bivalent, bispecific antibody that has the smaller kD value (dissociation constant) for the interaction with its antigen for the immobilization of the bivalent, bispecific antibody to a solid surface for the determination of the biological activity of the bivalent, bispecific antibody.

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating bronchiectasis, chronic obstructive pulmonary disorder, cystic fibrosis, chronic bronchitis or asthma comprising administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutical composition described herein.

Abstract: Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,45,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Abstract: Drug products in the form of modified release formulations comprising the drug substance (?)-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating bronchiectasis, chronic obstructive pulmonary disorder, cystic fibrosis, chronic bronchitis or asthma comprising administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutical composition described herein.

Abstract: A ship having a length to width ratio smaller than two and including a superstructure and at least two hulls, the superstructure forming a wing able to generate an aerodynamic lift comprised between 20 and 90% of the weight of the ship at a cruising speed thereof, the wing including curved ends connected to each of the hulls and having a developed surface of an extrados of the wing substantially equal to the product of the length by the width of the ship, wherein a point for application of the aerodynamic lift generated by the superstructure is situated behind the center of gravity for application of the gravitational forces on the ship, and a point for application of the resultant of the hydrodynamic forces generated by the hulls is situated in front of the center of gravity.

Abstract: Drug products in the form of modified release formulations comprising the drug substance (-)-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Abstract: The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterized in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.

Abstract: The invention relates to a method for acquiring seismic data at a plurality of positions spread out over a zone on the seabed which includes transmitting acoustic waves in the water layer above the zone by a plurality of sources, for each of the acquisition positions, dropping from the surface a seismic acquisition equipment, the equipment comprising a seismic acquisition unit and autonomous guiding equipment adapted to receive while descending acoustic signals from the sources and to control its trajectory according to the received acoustic signals so as to direct said equipment towards said position, performing the seismic acquisition, causing the acquisition equipments to move up to the surface, and retrieving the acquisition equipments on the surface.

Abstract: A method and device for the remote collection of data from aircraft or ship recorders, using a buoy (3) which may be ejected in the event of sinking and contains a double memory which stores the positions of the buoy during the drift thereof as well as information relating to the flight or crossing. A two-way radio communication means allows the buoy to transfer the contents of said memories to a remote collection means, which is a reconnaissance aeroplane.

Abstract: A device for heating a cylindrical component of given diameter is disclosed. The device includes at least two heaters each delivering a stream of hot gas and emerging in an annular chamber. The inside diameter of the annular chamber is slightly greater than the diameter of the cylindrical component. The device may be used for heating a metal journal in which a bearing ring for an inter-shaft bearing in a double-body turbomachine is mounted.

Abstract: A method and device for the remote collection of data from aircraft or ship recorders, using a buoy (3) which may be ejected in the event of sinking and contains a double memory which stores the positions of the buoy during the drift thereof as well as information relating to the flight or crossing.

Abstract: A seismic streamer incorporates apparatus for controlling its depth of immersion for modifying and maintaining its degree of immersion, wherein, the streamer being designed for stationary use and including a power supply network, the immersion control apparatus comprises a plurality of variable buoyancy ballasts connected to the power supply network of the streamer and installed at regular intervals along the seismic streamer and each associated with a microcontroller for at least controlling buoyancy of the corresponding ballast, a plurality of pressure sensors also installed at regular intervals along the streamer, at least one receiver for one or more desired value instructions, a bus for distributing the one or more desired value instructions to the ballasts, the microcontroller associated with a given ballasts being adapted to receive at least signals originating from at least one pressure sensor located in the proximity of the ballast and instruction signals originating from the receiver for instruction

Abstract: The invention relates to a method for acquiring seismic data at a plurality of positions spread out over a zone on the seabed which includes transmitting acoustic waves in the water layer above the zone by a plurality of sources, for each of the acquisition positions, dropping from the surface a seismic acquisition equipment, the equipment comprising a seismic acquisition unit and autonomous guiding equipment adapted to receive whilst descending acoustic signals from the sources and to control its trajectory according to the received acoustic signals so as to direct said equipment towards said position, performing the seismic acquisition, causing the acquisition equipments to move up to the surface, and retrieving the acquisition equipments on the surface.

Abstract: A device for heating a cylindrical component of given diameter is disclosed. The device includes at least two heaters each delivering a stream of hot gas and emerging in an annular chamber. The inside diameter of the annular chamber is slightly greater than the diameter of the cylindrical component. The device may be used for heating a metal journal in which a bearing ring for an inter-shaft bearing in a double-body turbomachine is mounted.

Abstract: A device for heating a cylindrical component of given diameter is disclosed. The device includes at least two heaters each delivering a stream of hot gas and emerging in an annular chamber. The inside diameter of the annular chamber is slightly greater than the diameter of the cylindrical component. The device may be used for heating a metal journal in which a bearing ring for an inter-shaft bearing in a double-body turbomachine is mounted.

Abstract: The invention relates to a method for acquiring seismic data at a plurality of positions spread out over a zone on the seabed which includes transmitting acoustic waves in the water layer above the zone by a plurality of sources, —for each of the acquisition positions, dropping from the surface a seismic acquisition equipment, the equipment comprising a seismic acquisition unit and autonomous guiding equipment adapted to receive whilst descending acoustic signals from the sources and to control its trajectory according to the received acoustic signals so as to direct said equipment towards said position, —performing the seismic acquisition, —causing the acquisition equipments to move up to the surface, and —retrieving the acquisition equipments on the surface.

Abstract: The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterised in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.

Abstract: A method of assembly of a turbomachine that includes a first module and a second module with a second shaft assembled by a bearing, the bearing including an outer ring shrink-fitted inside a journal integral with the first module and an inner ring integral with the second shaft. The second module is assembled on the first module by engagement of the second shaft, with the inner ring, inside the journal. The method includes a step of inserting the second module in the first module up to a determined distance such that the first and second modules are only partially assembled. The second shaft is centered with respect to the journal, the centering being controlled on the basis of measuring distance deviations with respect to a reference on the journal. The journal is expanded by heating its outer surface. After the step of expanding, the second module is displaced inside the first module so as to complete the assembly. This displacement step is started based on a predetermined temperature.

Abstract: The present invention relates to a device for heating a cylindrical component of given diameter, by means of hot gas, characterized in that it comprises at least two heaters (310, 312, 314) each delivering a stream of hot gas and emerging in an annular chamber (316), the inside diameter of which is slightly greater than said diameter. This device is used in particular for heating a metal journal (111) in which a bearing ring (123) for an inter-shaft bearing in a double-body turbomachine is mounted.