Patents by Inventor Hueng-Sik Choi

Hueng-Sik Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retinoid X receptor-interacting polypeptides and related molecules and methods
    Publication number: 20060287503
    Abstract: Disclosed is purified DNA encoding retinoid X receptor-interacting proteins and methods for producing RXR-interacting proteins expressed from such DNA.
    Type: Application
    Filed: May 30, 2006
    Publication date: December 21, 2006
    Inventors: David Moore, Wongi Seol, Hueng-Sik Choi
  • Retinoid X receptor-interacting polypeptides and related molecules and methods
    Patent number: 7115711
    Abstract: Disclosed is a method for determining whether a test protein is capable of interacting with a retinoid X receptor protein. The method involves: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including a retinoid X receptor protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the test protein covalently bonded to a gene activating moiety; and (b) determining whether the test protein increases expression of the reporter gene as an indication of its ability to interact with the retinoid X receptor protein. Also disclosed is purified DNA encoding retinoid X receptor-interacting proteins and the polypeptides expressed from such DNA.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: October 3, 2006
    Assignee: The General Hospital Corporation
    Inventors: David Moore, Wongi Seol, Hueng-Sik Choi
  • Car receptors and related molecules and methods
    Patent number: 6989242
    Abstract: Purified DNA encoding CAR receptors and the recombinant proteins expressed from such DNA are disclosed. The recombinant receptor polypeptides are used to identify CAR ligands and CAR receptor binding sites and are also used to produce therapeutics. Antibodies specific for CAR receptor polypeptides are also disclosed.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: January 24, 2006
    Assignee: The General Hospital Coporation
    Inventors: David D. Moore, Hueng-Sik Choi, Myriam I. Baes
  • Retinoid X receptor-interacting polypeptides
    Patent number: 5932699
    Abstract: Disclosed is a method for determining whether a test protein is capable of interacting with a retinoid X receptor protein. The method involves: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including a retinoid X receptor protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the test protein covalently bonded to a gene activating moiety; and (b) determining whether the test protein increases expression of the reporter gene as an indication of its ability to interact with the retinoid X receptor protein. Also disclosed is purified DNA encoding retinoid X receptor-interacting proteins and the polypeptides expressed from such DNA.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: August 3, 1999
    Assignee: The General Hospital Corporation
    Inventors: David Moore, Wongi Seol, Hueng-Sik Choi