Abstract: Topical compositions for skin include an active substance and a cell penetrating peptide consisting of following sequence: NYBX1BX2BNQX3. The cell penetrating peptide is not only capable of delivering the active substance into skin cells effectively but also promoting the activity of the active substance.

Abstract: Present invention relates to an allergy-inhibiting sea grape extract, its preparation method and thereof. The preparation method includes following steps: the sea grape is blended in distilled water in the weight ratio of 1:1˜20, mix thoroughly, stir at 20˜100° C. for 30˜120 minutes. The fluid obtained after the first filtration is the sea grape extract. The sea grape extract can be subjected to the second filtration by using EW, PW and DK membranes and freeze-dried to give a refined sea grape extract. The invention exhibits superior allergy-inhibiting effect; moreover, the prepared extract does not cause allergy and can be used in cosmetics and food.

Abstract: Present invention relates to an allergy-inhibiting sea grape extract, its preparation method and thereof. The preparation method includes following steps: the sea grape is blended in distilled water in the weight ratio of 1:1˜20, mix thoroughly, stir at 20-100° C. for 30˜120 minutes. The fluid obtained after the first filtration is the sea grape extract. The sea grape extract can be subjected to the second filtration by using EW, PW and DK membranes and freeze-dried to give a refined sea grape extract. The invention exhibits superior allergy-inhibiting effect; moreover, the prepared extract does not cause allergy and can be used in cosmetics and food.

Abstract: A method for preparing a composite matrix containing chitosan derivatives, comprising the steps of: (a) providing an anionic chitosan derivative solution (A); (b) providing a cationic polysaccharide solution (B); and (c) mixing solution (A) and solution (B) to form microcapsules. Metallic ion cross-linking agent and/or natural protein solution can be added optionally to adjust the mechanical strength of the shell and the interior physic state of the microcapsules.

Abstract: The present invention relates to a biodegradable thermal-sensitive gel system, which comprises at least one polysaccharide solution, at least one electrolytic salt, and at least one buffer solution for adjusting pH. A natural protein as well as a cross-linking agent can be added to the gel system optionally. Said gel system is liquid at room temperature (25° C.) and solidifies at or above 37° C.

Abstract: A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

Abstract: The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the chamber to effect crosslinking of the porous biodegradable polymer; and optionally (c) introducing a pure supercritical into the chamber to wash the crosslinked polymer until the crosslinking agent is substantially removed from the polymer.

Abstract: The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.

Abstract: The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the chamber to effect crosslinking of the porous biodegradable polymer; and optionally (c) introducing a pure supercritical into the chamber to wash the crosslinked polymer until the crosslinking agent is substantially removed from the polymer.

Abstract: A biodegradable composite matrix for enhancing angiogenesis. The matrix includes a biodegradable material and a phospholipid distributed in the biodegradable material as a liposome or micelle. Derivatives of phospholipid have chemo-attraction properties and thus induce the transfer of endothelial cells into the system through tropism-inductive mechanism. The biodegradable composite matrix induces an intracellular signal cascade that is different from cascade induced by a growth factor, and can coordinate with the growth factor-induced cascade to enhance angiogenesis. The present invention also includes the method for producing the biodegradable composite matrix.

Abstract: A biodegradable porous device for tissue engineering is disclosed, which comprises (A) a porous polymeric scaffold comprising a co-continuous phase of a first biodegradable polymer and a second biodegradable polymer which are incompatible with each other, wherein the first biodegradable polymer contains a continuous network of large, interconnected pores, and the second biodegradable polymer contains small, partially interconnected pores; (B) a biodegradable polymer fiber dispersed in, and compatible with the matrix of the first biodegradable polymer; and optionally (C) an active ingredient provided in the polymeric scaffold.

Abstract: A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

Abstract: The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.