Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.

Abstract: A recyclable package such as a Stand Up Pouch (SUP) is prepared using a coextruded polyethylene structure having a first surface layer, a first intermediate layer, a second intermediate layer, and a second surface layer which is a sealable layer. The coextruded structure contains two layers of High Density Polyethylene (HDPE) to provide stiffness. The structure also contains a layer of lower density polyethylene. The structure is optionally surface printed. This structure is suitable for preparing packages for a wide variety of flowable foods (including liquids and solids).

Abstract: Methods for altering feed throat passageway size, shape and position in a pellet fed extruder by means of a removable adapter are disclosed. Adapters chosen for optimal extrusion performance may be removed with little effort in a shorter time and may be more cost effective than other methods for optimization of extrusion including replacing the screw or by replacing the feed throat through purchase of a different extruder.

Abstract: A recyclable food package, such as Stand Up Pouch (SUP) is prepared using a polyethylene structure having a first web and a second web. Each of the first web and second web contains at least one layer of High Density Polyethylene (HDPE) to provide stiffness. The outer web also contains a layer of lower density polyethylene for improved optical properties. The laminated structure may be printed on one of the layers that form the interface between the two webs to protect the printing. This SUP design is suitable for preparing packages of a wide variety of flowable foods (including liquids and solids).

Abstract: A recyclable Stand Up Pouch (SUP) is prepared using a polyethylene structure having a first web and a second web. Each of the first web and second web contains at least one layer of High Density Polyethylene (HDPE) to provide stiffness. The outer web also contains a layer of lower density polyethylene for improved optical properties. The laminated structure is printed on one of the layers that form the interface between the two webs to protect the printing. This SUP design is suitable for preparing packages of a wide variety of flowable foods (including liquids and solids).

Abstract: The invention relates to a method for preparing an emulsion by membrane emulsification enabling control of the dispersed phase size and size distribution by interrupting extrusion of the dispersed phase.