Patents by Inventor Hugh Jonathan Herdon

Hugh Jonathan Herdon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER
    Publication number: 20090175788
    Abstract: Compounds of formula (I) and salts and solvates thereof, which are radiolabelled ligands for the glycine 1 transporter, are provided: wherein R1 is 3H, or a C1-6alkyl group incorporating a radionuclide selected from the group consisting of 3H, 11C, 14C, 13N, 15O, 76Br, 18F, 123I, 125I, 131I, 75Br, 76Br, 77Br and 82Br. Use of the compounds for the labelling and diagnostic imaging of the glycine 1 transporter functionality is disclosed.
    Type: Application
    Filed: June 20, 2007
    Publication date: July 9, 2009
    Inventors: Gabriella Gentile, Hugh Jonathan Herdon, Johannes Passchier, Roderick Alan Porter
  • Neurotransmitter transporter SC6
    Patent number: 6426405
    Abstract: The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: July 30, 2002
    Assignee: SmithKline Beecham P.L.C.
    Inventors: Anthony M Brown, Conrad Gerald Chapman, Israel Simon Gloger, Joanne Rachel Evans, William Cairns, Hugh Jonathan Herdon
  • Novel receptor
    Publication number: 20010027248
    Abstract: A receptor in substantially pure form obtainable from rat forebrain tissue which is characterized in that;
    Type: Application
    Filed: May 24, 2001
    Publication date: October 4, 2001
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Hugh Jonathan Herdon, Jeffrey Clifford Jerman, Wai Ngor Chan
  • Neurotransmitter transporter SC6
    Publication number: 20010012627
    Abstract: The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: February 28, 2001
    Publication date: August 9, 2001
    Inventors: Anthony M. Brown, Conrad Gerald Chapman, Israel Simon Gloger, Joanne Rachel Evans, William Cairns, Hugh Jonathan Herdon
  • Receptor that binds anti-convulsant compounds
    Patent number: 6245893
    Abstract: The claimed invention is substantially purified rat forebrain receptor, wherein said receptor: a) binds Compound A with a Kd of 40 nM and a Bmax of 220 pmol/g; b) binds Compound B with a Kd of 2 nM and a Bmax of 220 pmol/g protein; and c) has a molecular weight of about 130 kD. Compounds A and B are known anti-convulsant compounds, such that this receptor will be useful in screening for compounds that have therapeutic activity for the treatment of CNS-related disorders.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham P.L.C.
    Inventors: Hugh Jonathan Herdon, Jeffrey Clifford Jerman, Wai Ngor Chan
  • Neurotransmitter transporter SC6
    Patent number: 6238883
    Abstract: The SC6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SC6 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Anthony M Brown, Conrad Gerald Chapman, Israel Simon Gloger, Joanne Rachel Evans, William Cairns, Hugh Jonathan Herdon
  • Screening methods to identify anti-convulsant compounds
    Patent number: 5985334
    Abstract: A method for identifying anti-convulsant compounds is presented. The binding of test compounds with a receptor obtained from rat forebrain is determined. The receptor has a Kd of about 40 nM and a molecular weight of about 130 kD. Two pyran compounds that bind to the receptor are also disclosed.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: November 16, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Hugh Jonathan Herdon, Jeffrey Clifford Jerman, Wai Ngor Chan