Abstract: A method, system, and computer program product for automated testing of Internet of Things devices are provided. The method generates a device table for a set of devices. The device table includes a set of inputs and a set of controllable outputs for each device. A set of input signals are detected for a device for a subset of inputs associated with the device. The set of input signals are detected from one or more controllable outputs of a subset of devices. The device table is modified based on the set of input signals and the one or more controllable outputs to generate an association table representing a relation of the subset of inputs with the one or more controllable outputs. The method detects a fault in one or more device of the set of devices based on a test input signal and the association table.

Abstract: Provided are techniques for generating highlight queries. Data is analyzed using one or more schemas to identify patterns and frequencies of the patterns in the data. The patterns and the frequencies of the patterns are stored in a global patterns structure. A graph is analyzed to identify one or more of the patterns in the global patterns structure that are present in the graph and in which frequencies. The identified one or more of the patterns in the global patterns structure that are present in the graph are added to a per-user patterns structure with the frequencies of those patterns. The patterns in the per-user patterns structure are scored. A subset of the patterns in the per-user patterns structure that have scores above a threshold are selected as highlight queries. The selected subset of the patterns are executed as highlight queries to generate results, and the results are returned.

Abstract: Provided are techniques for generating highlight queries. Data is analyzed using one or more schemas to identify patterns and frequencies of the patterns in the data. The patterns and the frequencies of the patterns are stored in a global patterns structure. A graph is analyzed to identify one or more of the patterns in the global patterns structure that are present in the graph and in which frequencies. The identified one or more of the patterns in the global patterns structure that are present in the graph are added to a per-user patterns structure with the frequencies of those patterns. The patterns in the per-user patterns structure are scored. A subset of the patterns in the per-user patterns structure that have scores above a threshold are selected as highlight queries. The selected subset of the patterns are executed as highlight queries to generate results, and the results are returned.

Abstract: This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >1010) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed.

Abstract: A computing device, or a security component of a computing device, implements delayed attestation by initially providing first credentials to a remote access device to establish a first level of trust. The first credentials may be provided before or while the computing device or the security component is obtaining security information from a remote security device. The security information is used to generate second credentials that are subsequently provided to the remote access device to establish a second level of trust. The first credentials may comprise an encryption key that can be generated by the security component without having to retrieve information via a network, and the second credentials may comprise an attestation statement that is more trustworthy than the encryption key and that is generated based on a certificate retrieved from a remote security device (e.g., a certificate authority server).

Abstract: A computing device, or a security component of a computing device, implements delayed attestation by initially providing first credentials to a remote access device to establish a first level of trust. The first credentials may be provided before or while the computing device or the security component is obtaining security information from a remote security device. The security information is used to generate second credentials that are subsequently provided to the remote access device to establish a second level of trust. The first credentials may comprise an encryption key that can be generated by the security component without having to retrieve information via a network, and the second credentials may comprise an attestation statement that is more trustworthy than the encryption key and that is generated based on a certificate retrieved from a remote security device (e.g., a certificate authority server).

Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.

Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.

Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilising a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.

Abstract: A method of preparing a solution for use in DNA amplification reactions, including the steps of, mixing a binding agent with a base solution; subjecting the mixture (of a binding agent and base solution) to a stimulus which activates the binding agent, and upon activation, the binding agent binding to any DNA in the base solution so that it is unreactive and is not co-amplified during the DNA amplification reaction.

Abstract: Alkalophilic and thermophilic cellulases having high stability to elevated temperatures and pH have been isolated from an organism of unknown species, which most closely resembles those in the Caldicellulosiruptor genus and which has been called by us, Tok7B.1, These cellulases have been cloned and expressed in a recombinant system, so that they can be produced in quantity. These are particularly useful in treating cellulosic materials including cotton-containing fabrics, as detergent additives, and in aqueous compositions. We also provide genomic DNA which can be used in recombinant expression vectors and expression systems to produce enhanced alkali and/or temperature stability properties in cellulases other than those specifically described.

Abstract: A linear feedback shift register (LFSR) of interest is modelled in software by replicating the LFSR in at least two identically configured model LFSRs. One model LFSR contains only the higher order initial bits of the LFSR of interest, with zeroes in the lower order bit positions, and the other model LFSR has only the lower order bits, with zeroes in the higher order bit positions. The model LFSRs are represented by respective tables of model LFSR output values that would be produced after a predetermined number of register shifts. The tables are accessed based on the initial value of the LFSR of interest, and the results of one table are combined with the results of the other table using an exclusive OR operator to thereby determine the output of the LFSR of interest.