Patents by Inventor Hugo Caro

Hugo Caro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and their uses
    Publication number: 20050215491
    Abstract: Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. In particular, the compounds are based on the 1,6 linkage of a sugar residue and a cyclitol.
    Type: Application
    Filed: May 19, 2005
    Publication date: September 29, 2005
    Inventors: Manuel Martin-Lomas, Thomas Rademacher, Hugo Caro, Irene Francois
  • Treatment and diagnosis of cancer using inositolphosphoglycans antagonists
    Publication number: 20050031622
    Abstract: Inositolphosphoglycans (IPGs), and in particular A-type substances comprising myo-inositol, are tumour autocrine factors (TAFs), that is factors which cause tumour cell proliferation. The use of A-type IPG antagonists for the treatment of cancer and a method for the diagnosis or prognosis of cancer based on the presence or amount of IPGs in a sample from a patient is disclosed.
    Type: Application
    Filed: June 16, 2004
    Publication date: February 10, 2005
    Inventors: Thomas Rademacher, Hugo Caro
  • Cyclitol containing carbohydrates from human tissue which regulate glycogen metabolism
    Publication number: 20040022782
    Abstract: The application relates to the purification and characterisation of a family of P-type inositolphosphoglycans (IPGs) from human liver and placenta. These substances are shown to have P-type biological activity, e.g. activating pyruvate dehydrogenase (PDH) phosphatase. The characterisation of the compounds demonstrates that they contain metal ions, in particular Mn2+ and/or Zn2+, and optionally phosphate. The compounds and their antagonists have uses as pharmaceuticals, e.g. for the treatment of diabetes, and in screening for synthetic analogues.
    Type: Application
    Filed: June 18, 2003
    Publication date: February 5, 2004
    Applicant: Rodaris Pharmaceuticals Limited
    Inventors: Thomas William Rademacher, Hugo Caro
  • Cyclitol containing carbohydrates from human tissue which regulate lipogenic activity
    Publication number: 20010039027
    Abstract: The application relates to the purification and characterization of a family of A-type inositolphosphoglycans (IPGs) from human liver and placenta. These substances are shown to have the biological activity associated with A-type IPG fractions, namely regulating lipogenic activity and inhibiting cAMP dependent protein kinase. The characterization of the compounds demonstrates that they contain metal ions, in particular Zn2+, and optionally phosphate. The compounds and their antagonists have uses as pharmaceuticals, e.g. for the treatment of diabetes, and in screening for synthetic analogs.
    Type: Application
    Filed: February 1, 2001
    Publication date: November 8, 2001
    Inventors: Thomas William Rademacher, Hugo Caro
  • Cyclitol Containing carbohydrates from human tissue which regulate lipogenic activity
    Patent number: 6303580
    Abstract: The present invention provides for an isolated A-type substance having a structure identical to an A-type substance obtained from human liver or placenta, which is a cyclical containing carbohydrate comprising Zn2+ and related compositions.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: October 16, 2001
    Assignee: Rademacher Group Limited
    Inventors: Thomas William Rademacher, Hugo Caro
  • Cyclitol containing carbohydrates from human tissue which regulate glycogen metabolism
    Patent number: 6271204
    Abstract: The present invention provides for an isolated P-type substance having a structure identical to a P-type substance obtained from human liver or placenta, which is a cyclitol containing carbohydrate comprising Mn2+ and Zn2+ and related compositions.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: August 7, 2001
    Assignee: Rademacher Group Limited
    Inventors: Thomas William Rademacher, Hugo Caro
  • Use of glycosidase inhibitors
    Patent number: 5981494
    Abstract: The present invention is directed to the use of glycosidase inhibitors for inhibiting the conversion of a pro-toxin to a toxin by a glycosidase enzyme. In particular, the present invention relates to the use of glycosidase inhibitors for the treatment of malaria, endotoxic shock or septic shock.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: November 9, 1999
    Assignee: University College London
    Inventors: Thomas Rademacher, John Playfair, Hugo Caro, Janice Taverne, Nadeem Sheikh