Patents by Inventor Hugo de Almeida SILVA

Hugo de Almeida SILVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034159
    Abstract: Disclosed herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, that are inhibitors of inhibitors of epidermal growth factor receptor (EGFR), including EGFR C797S mutants. Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 24, 2022
    Publication date: January 30, 2025
    Inventors: Brian R. BLANK, Paul Anthony GIBBONS, Chudi NDUBAKU, F. Anthony ROMERO, Jae Hyuk CHANG, Johnny D. PHAM, Tucker Curran ROBERTS, Rakesh Harsukhlal VEKARIYA, Alexandria Daria Maria JEANNERET, Hugo de Almeida SILVA, Raphael Oluwagbemiga DADA, Kyle Conner McINTOSH, Estelle NEIGER, William BROWN, Harumi TAKASAKI, Cynthia Charlene CRIFAR, Dilan Emine POLAT
  • Publication number: 20240270722
    Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 10, 2022
    Publication date: August 15, 2024
    Inventors: Chudi NDUBAKU, Jared Thomas MOORE, Paul Anthony GIBBONS, Jae Hyuk CHANG, F. Anthony ROMERO, Xiaohui DU, Hiroyuki KAWAI, Stephane CIBLAT, Hong WANG, Vincent ALBERT, Lea CONSTANTINEAU-FORGET, Hugo de Almeida SILVA, Dilan Emine POLAT, Amit NAYYAR, Daniel Gordon Michael SHORE, Kejia WU, Joanne TAN
  • Publication number: 20240124426
    Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 18, 2023
    Publication date: April 18, 2024
    Inventors: Chudi NDUBAKU, Jared Thomas MOORE, Paul Anthony GIBBONS, Jae Hyuk CHANG, F. Anthony ROMERO, Xiaohui DU, Hiroyuki KAWAI, Stephane CIBLAT, Hong WANG, Vincent ALBERT, Lea CONSTANTINEAU-FORGET, Hugo de Almeida SILVA, Dilan Emine POLAT, Amit NAYYAR, Daniel Gordon Michael SHORE, Kejia WU, Joanne TAN
  • Patent number: 11858915
    Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 27, 2023
    Date of Patent: January 2, 2024
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Chudi Ndubaku, Jared Thomas Moore, Paul Anthony Gibbons, Jae Hyuk Chang, F. Anthony Romero, Xiaohui Du, Hiroyuki Kawai, Stephane Ciblat, Hong Wang, Vincent Albert, Lea Constantineau-Forget, Hugo De Almeida Silva, Dilan Emine Polat, Amit Nayyar, Daniel Gordon Michael Shore, Kejia Wu, Joanne Tan
  • Publication number: 20230365537
    Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 16, 2023
    Inventors: Chudi NDUBAKU, Jared Thomas MOORE, Paul Anthony GIBBONS, Jae Hyuk CHANG, F. Anthony ROMERO, Xiaohui DU, Hiroyuki KAWAI, Stephane CIBLAT, Hong WANG, Vincent ALBERT, Lea CONSTANTINEAU-FORGET, Hugo de Almeida SILVA, Dilan Emine POLAT, Amit NAYYAR, Daniel Gordon Michael SHORE, Kejia WU, Joanne TAN