Patents by Inventor Hugo Hubertus Knobel
Hugo Hubertus Knobel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11519900Abstract: A method for synchronizing data for gas samples with volatile organic compounds. The data includes chromatographic data indicative of molecule retention times. The method includes identifying or selecting marker molecules and clustering the plurality of gas samples into a plurality of clusters according to a clustering criterion. Next, a first correction of retention time deviations is performed on the data for the gas samples between clusters by using the marker molecules as anchor points to provide a coarse reduction of retention time deviations between the data. Finally, a second correction of retention time deviations is performed on the data, so as to further reduce retention time deviations between the data. The method reduces significant retention time deviations to allow, e.g., breath sample fingerprints obtained by different equipment at different times to be compared in one database for use on a digital platform.Type: GrantFiled: January 17, 2018Date of Patent: December 6, 2022Assignee: Koninklijke Philips N.V.Inventors: Johannes Weda, Teunis Johannes Vink, Hugo Hubertus Knobel, Tamara Mathea Elisabeth Nijsen
-
Publication number: 20210356453Abstract: A method (RT_A) for synchronizing data for a plurality of gas samples, e.g. breath samples, with volatile organic compounds. The data comprises chromatographic data indicative of molecule elution times, and preferably also mass spectrography data. The method comprises identifying or selecting (I_MM) marker molecules, e.g. 5-20 molecules, preferably easily identifiable molecules for each of the plurality of gas samples, and clustering (CL) the plurality of gas samples into a plurality of clusters according to a clustering criterion, e.g. including additional information such as time of obtaining the data and/or analyzing equipment used. Next, a first correction of retention time deviations (P_C1) is performed on the data for the gas samples between clusters by using the marker molecules as anchor points, so as to provide a coarse reduction of retention time deviations (d) between the data for the gas samples.Type: ApplicationFiled: January 17, 2018Publication date: November 18, 2021Inventors: JOHANNES WEDA, TEUNIS JOHANNES VINK, HUGO HUBERTUS KNOBEL, TAMARA MATHEA ELISABETH NIJSEN
-
Patent number: 11054412Abstract: Exhaled breath analysis in health and disease is an area of growing clinical interest with the potential to be adopted through the whole respiratory healthcare continuum. However, currently there is no standard for exhaled breath collection, and the optimal way to preconcentrate the highly humid exhaled breath is not known. Described is an optimized combination of sorbent materials and sample handling methods that allows quantitative capturing of exhaled molecules over a broad range in highly humid conditions. The invention can be applied in pre-concentration units of future devices for exhaled breath analysis, for example at the bedside.Type: GrantFiled: September 9, 2016Date of Patent: July 6, 2021Assignee: Koninklijke Philips N.V.Inventors: Hugo Hubertus Knobel, Ruud Johannes Theodorus Soers, Tamara Mathea Elisabeth Nijsen, Johannes Weda
-
Publication number: 20180246078Abstract: Exhaled breath analysis in health and disease is an area of growing clinical interest with the potential to be adopted through the whole respiratory healthcare continuum. However, currently there is no standard for exhaled breath collection, and the optimal way to preconcentrate the highly humid exhaled breath is not known. Described is an optimized combination of sorbent materials and sample handling methods that allows quantitative capturing of exhaled molecules over a broad range in highly humid conditions. The invention can be applied in pre-concentration units of future devices for exhaled breath analysis, for example at the bedside.Type: ApplicationFiled: September 9, 2016Publication date: August 30, 2018Inventors: HUGO HUBERTUS KNOBEL, RUUD JOHANNES THEODORUS SOERS, TAMARA MATHEA ELISABETH NIJSEN, JOHANNES WEDA
-
Patent number: 9719969Abstract: A pre-concentration device is provided for a gas analysis system (10) for collecting molecular contamination in a vacuum environment (11). The pre-concentration device (13) comprises a hollow element (15) having an entrance opening (20) for receiving molecules from the vacuum environment (11) in a collection phase, a gas outlet for transferring collected molecules to a vacuum compatible detector or second preconcentration device in a transfer phase. The device has an inner wall for adsorbing molecules in the collection phase and desorbing molecules in the transfer phase. The device has a filler element (14) that is movable from a first position outside the hollow element in the collection phase to a second position inside the hollow element in the transfer phase which second position leaves open a transfer channel to the gas outlet along the inner wall.Type: GrantFiled: May 25, 2016Date of Patent: August 1, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Ruud Johannes Theodorus Soers, Hugo Hubertus Knobel, Pieter Klaas De Bokx
-
Publication number: 20160266075Abstract: A pre-concentration device is provided for a gas analysis system (10) for collecting molecular contamination in a vacuum environment (11). The pre-concentration device (13) comprises a hollow element (15) having an entrance opening (20) for receiving molecules from the vacuum environment (11) in a collection phase, a gas outlet for transferring collected molecules to a vacuum compatible detector or second preconcentration device in a transfer phase. The device has an inner wall for adsorbing molecules in the collection phase and desorbing molecules in the transfer phase. The device has a filler element (14) that is movable from a first position outside the hollow element in the collection phase to a second position inside the hollow element in the transfer phase which second position leaves open a transfer channel to the gas outlet along the inner wall.Type: ApplicationFiled: May 25, 2016Publication date: September 15, 2016Inventors: Ruud Johannes Theodorus SOERS, Hugo Hubertus KNOBEL, Pieter Klaas DE BOKX
-
Patent number: 9375671Abstract: A pre-concentration device is provided for a gas analysis system (10) for collecting molecular contamination in a vacuum environment (11). The pre-concentration device (13) comprises a hollow element (15) having an entrance opening (20) for receiving molecules from the vacuum environment (11) in a collection phase, a gas outlet for transferring collected molecules to a vacuum compatible detector or second preconcentration device in a transfer phase. The device has an inner wall for adsorbing molecules in the collection phase and desorbing molecules in the transfer phase. The device has a filler element (14) that is movable from a first position outside the hollow element in the collection phase to a second position inside the hollow element in the transfer phase which second position leaves open a transfer channel to the gas outlet along the inner wall.Type: GrantFiled: October 20, 2011Date of Patent: June 28, 2016Assignee: Koninklijke Philips N.V.Inventors: Ruud Johannes Theodorus Soers, Hugo Hubertus Knobel, Pieter Klaas De Bokx
-
Publication number: 20130199269Abstract: A pre-concentration device is provided for a gas analysis system (10) for collecting molecular contamination in a vacuum environment (11). The pre-concentration device (13) comprises a hollow element (15) having an entrance opening (20) for receiving molecules from the vacuum environment (11) in a collection phase, a gas outlet for transferring collected molecules to a vacuum compatible detector or second preconcentration device in a transfer phase. The device has an inner wall for adsorbing molecules in the collection phase and desorbing molecules in the transfer phase. The device has a filler element (14) that is movable from a first position outside the hollow element in the collection phase to a second position inside the hollow element in the transfer phase which second position leaves open a transfer channel to the gas outlet along the inner wall.Type: ApplicationFiled: October 20, 2011Publication date: August 8, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Ruud Johannes Theodorus Soers, Hugo Hubertus Knobel, Pieter Klaas De Bokx