Abstract: The present invention refers to new amorphous and crystalline solid forms of desvenlafaxine, also known as O-desmethylvenlafaxine or desmethylvenlafaxine, and to its salts, solvates, hydrates and polymorphs thereof, as well as to their use in the manufacture of a pharmaceutical composition useful in the treatment of depression and/or as a selective serotonin and norepinephrine reuptake inhibitor and also in menopause-associated vasomotor disorders.

Abstract: Natural, organic, environmentally “green” biocide compositions comprising oregano oil in various natural delivery media.

Abstract: The present invention refers to new amorphous and crystalline solid forms of desvenlafaxine, also known as O-desmethylvenlafaxine or desmethylvenlafaxine, and to its salts, solvates, hydrates and polymorphs thereof, as well as to their use in the manufacture of a pharmaceutical composition useful in the treatment of depression and/or as a selective serotonin and norepinephrine reuptake inhibitor and also in menopause-associated vasomotor disorders.

Abstract: The invention relates to novel solid forms of fluoroquinolones, in particular to complex co-crystals and to solvates, hydrates and polymorphs thereof. These substances can be used to prepare a pharmaceutical composition containing same as an active ingredient, which can be used as an antibiotic. The compounds have a storage stability that is constant and above that of the salts or hydrates thereof.

Abstract: Natural, organic, environmentally “green” biocide compositions comprising oregano oil in various natural delivery media.

Abstract: The present invention relates to co-crystals of tadalafil with hydroxyl-substituted benzoic acid coformers having the following structure. Said co-crystals can be used to produce a pharmaceutical composition containing the same as the useful active ingredient. Said co-crystals can exhibit a constant storage stability.

Abstract: The present invention relates to novel solid forms of phosphodiesterase type 5 (PDE5) inhibitors, especially to complex co-crystals, and to the solvates and/or the polymorphs of same. Said substances can be used to produce a pharmaceutical composition containing same as the useful active ingredient. Said compounds can exhibit a constant storage stability.

Abstract: The present invention relates to the field of human and veterinary medicine. The invention solves the problem associated with the lack of an agent for improving the immune response in immunosuppressed individuals, or with autoimmunity problems as well as infections; reducing the effects of the stress, combating tissue fibrosis; the need for anti-inflammatory agents; treatments for acute and chronic hepatitis, treatments against malignant processes and metastasis, as well as thrombocytopenia, both in humans and animals. The present invention comprises a molecular complex formed by a metallic ion and a peptide as novel compound, which is denominated as an immunomodulator metallopeptide hereafter abbreviated as IMMP. Claims also include the process for obtaining the complex, the use of the metallopeptide for producing a therapeutic or nutraceutic agent, and the use of that agent in humans and animals.

Abstract: The invention relates to novel solid forms of fluoroquinolones, in particular to complex co-crystals and to solvates, hydrates and polymorphs thereof. These substances can be used to prepare a pharmaceutical composition containing same as an active ingredient, which can be used as an antibiotic. The compounds have a storage stability that is constant and above that of the salts or hydrates thereof.

Abstract: A system and method for completing a well with multiple zones of production is provided, including a casing having a plurality of valves integrated therein for isolating each well zone, establishing communication between each underlying formation and the interior of the casing, delivering a treatment fluid to each of the multiple well zones, and filtering produced fluids from each underlying formation.

Abstract: The present invention relates to methods of designing a hydraulic fracturing treatment in a subterranean reservoir and methods of treatment. Methods of the invention include quantifying reservoir parameters such as bottomhole temperature and formation permeability, then assessing the temporary variation in temperature of the formation due to the injection of calibration and/or clean up fluids. Treatment fluids are then design based upon the temporary temperature. The fluids are then pumped to treat the reservoir.

Abstract: A method of designing a hydraulic fracturing treatment in a subterranean reservoir comprising the steps of a) quantifying reservoir parameters including the bottomhole temperature and the formation permeability, b) assessing the temporary variation in temperature of the formation due to the injection of a treatment fluid and c) designing a fluid optimized for said temporary temperature.