Patents by Inventor Hugo O. Jauregui

Hugo O. Jauregui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of cryopreserving hepatocytes
    Patent number: 6136525
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99%. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: October 24, 2000
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler
  • Immortalized hepatocytes
    Patent number: 6107043
    Abstract: The invention features a virally-immortalized mammalian hepatocyte, which is derived from a normal liver cell, has differentiated hepatocyte-specific metabolic activity, has the ability to proliferate, and is nontumorigenic after prolonged culture.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: August 22, 2000
    Assignee: Rhode Island Hospital
    Inventors: Hugo O. Jauregui, Jin Liu
  • Isolation and culture of porcine hepatocytes
    Patent number: 6017760
    Abstract: A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and porcine hepatocytes isolated from a porcine liver by retrograde perfusion.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: January 25, 2000
    Assignee: Rhode Island Hospital
    Inventors: Hugo O. Jauregui, Sharda Naik, Henry Santangini, Donna M. Trenkler
  • Immortalized hepatocytes
    Patent number: 5869243
    Abstract: The invention features a virally-immortalized mammalian hepatocyte, which is derived from a normal liver cell, has differentiated hepatocyte-specific metabolic activity, has the ability to proliferate, and is nontumorigenic after prolonged culture.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: February 9, 1999
    Assignee: Rhode Island Hospital
    Inventors: Hugo O. Jauregui, Jin Liu
  • Cryopreserved hepatocytes and high viability and metabolic activity
    Patent number: 5795711
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99% and a metabolic activity 50-80% of fresh hepatocytes. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: August 18, 1998
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler
  • Perfusion device with hepatocytes
    Patent number: 5043260
    Abstract: A perfusion device to grow and maintain hepatocytes including a chamber having a perfusion inlet and a perfusion outlet, a semipermeable membrane in the chamber defining separate perfusion and hepatocyte compartments, and hepatocytes in the hepatocyte compartment attached via oligosaccharide-lectin recognition linkage to a biopolymer support in the hepatocyte compartment.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: August 27, 1991
    Assignee: Rhode Island Hospital
    Inventor: Hugo O. Jauregui
  • Implantable prosthetic device with lectin linked endothelial cells
    Patent number: 4795459
    Abstract: An implantable prosthetic device made of biocompatible polymer and having a substantially continuous layer of autologus living cells attached via oligosaccharidelectin recognition linkages.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: January 3, 1989
    Assignee: Rhode Island Hospital
    Inventor: Hugo O. Jauregui