Patents by Inventor Hugo Vanderstichele

Hugo Vanderstichele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of tauopathies
    Patent number: 7387879
    Abstract: The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: June 17, 2008
    Assignee: Innogenetics N.V.
    Inventors: Eugeen Vanmechelen, Hugo Vanderstichele
  • Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
    Publication number: 20080057593
    Abstract: Methods are provided for the prediction, diagnosis and differential diagnosis of Alzheimer's disease. More particularly, a method is provided to determine whether a subject that does not show any clinical signs of Alzheimer's disease has a likelihood to develop Alzheimer's disease. Further a method is provided for the diagnosis of subjects suffering from Alzheimer's disease and/or for the differential diagnosis of subjects suffering from Alzheimer's disease versus subjects suffering from other dementias such as dementia with Lewy bodies. The methods are based on the determination of the ratio of specific A? peptides.
    Type: Application
    Filed: June 5, 2007
    Publication date: March 6, 2008
    Inventors: Hugo Vanderstichele, Eugeen Vanmechelen, Geert De Meyer, Kaj Blennow, Vesna Kostanjevecki
  • Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
    Publication number: 20040265919
    Abstract: Methods are provided for the prediction, diagnosis and differential diagnosis of Alzheimer's disease. More particularly, a method is provided to determine whether a subject that does not show any clinical signs of Alzheimer's disease has a likelihood to develop Alzheimer's disease. Further a method is provided for the diagnosis of subjects suffering from Alzheimer's disease and/or for the differential diagnosis of subjects suffering from Alzheimer's disease versus subjects suffering from other dementias such as dementia with Lewy bodies. The methods are based on the determination of the ratio of specific A&bgr; peptides.
    Type: Application
    Filed: May 19, 2004
    Publication date: December 30, 2004
    Inventors: Hugo Vanderstichele, Eugeen Vanmechelen, Geert De Meyer, Kaj Blennow, Vesna Kostanjevecki
  • Diagnosis of tauopathies
    Publication number: 20040091942
    Abstract: The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
    Type: Application
    Filed: October 9, 2003
    Publication date: May 13, 2004
    Applicant: INNOGENETICS N.V.
    Inventors: Eugeen Vanmechelen, Hugo Vanderstichele
  • Differential diagnosis of neurodegeneration
    Publication number: 20040014142
    Abstract: The present invention relates to new methods for the specific detection, quantification and/or differential diagnosis of neurodegeneration in an individual making use of a combination assay detecting at least three neurological markers in one or more body fluids of said individual, the type and degree of neurodegeneration being reflected in the quantitative changes in the level of all of said neurological markers compared to the control sample. The present invention also relates to methods for the detection of Rab3a, SNAP25 and &agr;-synuclein in cerebrospinal fluid and to the use of these methods in a combination assay for specific detection, quantification and/or differential diagnosis of neurodegeneration.
    Type: Application
    Filed: May 22, 2003
    Publication date: January 22, 2004
    Applicant: INNOGENETICS N.V.
    Inventors: Eugeen VanMechelen, Hugo Vanderstichele, Andre Van De Voorde
  • Diagnosis of tauopathies
    Patent number: 6680173
    Abstract: The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: January 20, 2004
    Assignee: Innogenetics N.V.
    Inventors: Eugeen Vanmechelen, Hugo Vanderstichele
  • Differential diagnosis of neurological diseases
    Patent number: 6670137
    Abstract: The present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus and individual suffering from another neurological disease. More specifically, the present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus an individual suffering from dementia with Lewy bodies, versus an individual suffering from Parkinson's disease without dementia, versus an individual suffering from multi-system atrophy and/or versus an individual suffering from progressive supranuclear palsy, said method characterized that phospho-tau is used as a neurological marker.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: December 30, 2003
    Assignee: Innogenetics N.V.
    Inventors: Eugeen VanMechelen, Hugo Vanderstichele, Frank Hulstaert
  • DIAGNOSIS OF TAUOPATHIES
    Publication number: 20030194742
    Abstract: The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
    Type: Application
    Filed: January 24, 2001
    Publication date: October 16, 2003
    Inventors: Eugeen Vanmechelen, Hugo Vanderstichele
  • Differential diagnosis of neurological diseases
    Publication number: 20020019016
    Abstract: The present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus and individual suffering from another neurological disease. More specifically, the present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus an individual suffering from dementia with Lewy bodies, versus an individual suffering from Parkinson's disease without dementia, versus an individual suffering from multi-system atrophy and/or versus an individual suffering from progressive supranuclear palsy, said method characterized that phospho-tau is used as a neurological marker.
    Type: Application
    Filed: June 27, 2001
    Publication date: February 14, 2002
    Inventors: Eugeen Vanmechelen, Hugo Vanderstichele, Frank Hulstaert