Patents by Inventor Hugo Villar

Hugo Villar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes
    Patent number: 7964534
    Abstract: The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 21, 2011
    Assignee: Triad Liquidating Company, LLC
    Inventors: Mark Kelly, Hugo Villar, Jianqiang Wang, Min S. Lee, Yong Qin, Daniel S. Sem
  • NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES
    Publication number: 20110118148
    Abstract: The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
    Type: Application
    Filed: March 12, 2004
    Publication date: May 19, 2011
    Inventors: Mark Kelly, Hugo Villar, Jianqiang Wang, Min S. Lee, Yong Qin, Daniel S. Sem
  • Antagonists of MCP-1 function and methods of use thereof
    Publication number: 20050054668
    Abstract: Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.
    Type: Application
    Filed: October 19, 2004
    Publication date: March 10, 2005
    Inventors: Edgardo Laborde, Louise Robinson, Fanying Meng, Brian Peterson, Hugo Villar, Steven Anuskiewicz, Yoshiro Ishiwata, Shoji Yokochi, Yukiharu Matsumoto, Takuji Kakigami, Hideaki Inagaki, Takahito Jomori, Kouji Matsushima