Abstract: The invention provides compounds of formulae (I-1), or formulae (I-2), and pharmaceutically acceptable salts and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors; as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit, CSF1R, and PDGFR (PDGFR?, PDGFR?) kinases.

Abstract: The present invention belongs to the field of protein engineering, and relates to a hybrid peptide formed by a chymotrypsin inhibitory peptide and an insulin or an analog thereof. The hybrid insulin analogue can resist the degradation of the chymotrypsin to improve the stability, such that the curative effect of direct injection administration can be improved, and moreover, the insulin analogue can penetrate through small intestine epithelium to be directly absorbed and enter blood circulation, thereby achieving oral administration of insulin hybrid peptidedrugs. The present invention further provides a method for preparing a hybrid peptide comprising the chymotrypsin inhibiting peptide and insulin or an analog thereof.

Abstract: The present application relates to the technical field of battery equipment and electric vehicles, disclosing a battery pack liquid-cooled plate and a battery pack. A battery pack liquid-cooled plate comprises: a liquid-cooled bottom plate for bottom cooling of a battery, wherein a first cooling channel is provided in the liquid-cooled bottom plate; multiple liquid-cooled side plates used for side cooling of the battery, wherein a second cooling channel is provided in each liquid-cooled side plate, each liquid-cooled side plate and the liquid-cooled bottom plate are arranged perpendicular to each other, and a flow channel of each liquid-cooled side plate interconnects with each other through a multi-pass device to form a flow-channel structure.

Abstract: A sodium ion battery cathode material and its preparation method and application, belonging to the field of sodium ion battery technology. The sodium ion battery cathode material includes a polyanionic iron-manganese core material and a fast ion conductor layer coated on the outer surface of said polyanionic iron-manganese core material; the polyanionic iron-manganese core material contains iron and manganese, and the iron and manganese are non-uniformly distributed within the polyanionic iron-manganese core material; at the center of the polyanionic iron-manganese core material, the manganese content is higher than the iron content; on the surface layer of the polyanionic iron-manganese core material, the iron content is higher than the manganese content. The non-uniform distribution of iron and manganese can effectively mitigate the risk of structural collapse caused by metal ion migration during cycling; the fast ion conductor coating reduces side reactions caused by electrolyte erosion.

Abstract: A free-radical in-situ polymerization semi-solid-state battery includes a positive electrode, a negative electrode and a semi-solid electrolyte. The semi-solid electrolyte is formed through in-situ polymerization by adding a polymerizable monomer, a plasticizer and an initiator into a liquid electrolyte. The polymerizable monomer is a combination of vinylene carbonate (VC) and trimethylene carbonate (TMC) with a mass ratio of 20 to 35:0.1 to 1.5. By optimizing the components of the gel electrolyte, the impedance of the battery is reduced, the performance of the battery is improved, the hardness of the gel electrolyte is enhanced, the solid-solid interface in the battery is benefited, and the safety of the battery is improved.

Abstract: The present invention relates to a secondary battery electrolyte, which includes a composite electrolyte salt; the composite electrolyte salt comprises lithium hexafluorophosphate, lithium difluorosulfonate, and lithium sulfide salts; the lithium sulfide salts include substituted sulfates (R1—SO3—Li) and/or sulfonate structure lithium salts (R2—O—SO3—Li). The present invention employs a combination of LiPF6, lithium sulfide salts, and LiFSI, where LiFSI exhibits better hydrolysis stability, superior thermal stability, and higher lithium migration capability, significantly enhancing the battery's kinetics and high-temperature performance. Lithium sulfates and sulfonate structure lithium salts also possess high lithium migration capabilities. Moreover, their anion groups rich in S and O form films that improve the composition of the SEI film and reduce membrane impedance, thereby enhancing the battery's kinetic and high-temperature performance.

Abstract: A self-repair binder for batteries and its preparation method, which consists of binder, additives, solvent, and self-repair agent. The self-repair agent includes polymer microcapsules, which consist of capsule wall material and repair liquid core material. Additives act as thickeners to improve the viscosity and flowability of the binder, making it easier to apply and coat on the battery surface. The self-repair agent can be encapsulated by polymer microcapsules, allowing it to automatically release the repair binder when the battery suffers minor damage, thus achieving self-repair functionality. Additionally, the repair binder has excellent interfacial bonding with both the binder and the active materials of the cathode and anode, ensuring long-term repair effectiveness.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to a panel of ER regulated genes and method for using the panel for monitoring the response of an individual having cancer to treatment with amcenestrant, the method comprising determining a first ER activity score from a sample from the individual at a first time point before treatment with amcenestrant using the panel, then determining a second ER activity score from a sample from the individual at a second time point following administration of amcenestrant using the panel, and comparing the first ER activity score with the second ER activity score, wherein a decrease in the second ER activity score relative to the first ER activity score is predictive of target engagement of amcenestrant.

Abstract: Preparation of a silicon composite material, and a negative electrode plate containing same, relating to the field of silicon-based composite materials. The silicon composite material comprises silicon nanoparticles, carbon nanotubes, silicon oxide, lithium oxide, and lithium metasilicate. The carbon nanotubes and the silicon nanoparticles are dispersed and cross-linked to form a three-dimensional network structure. Silicon oxide, lithium oxide, and lithium metasilicate cover the three-dimensional network structure to form secondary particles. The secondary particles and graphite are homogenized and coated according to a specific particle size ratio to prepare the negative electrode plate containing the silicon composite material and having high-capacity development, good conductivity, high coulombic efficiency, small volume expansion, and high cycling stability.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Provided is a phase shifter including: a supporting board, a circuit board, a transmission structure, and an adjusting structure. The circuit board and the transmission structure are disposed on two sides of the supporting board. The adjusting structure is rotatably connected to the circuit board and the supporting board. The transmission structure includes a gear, a gear rack and an arc-shaped internal gear. The gear is engaged with the gear rack and the arc-shaped internal gear. The arc-shaped internal gear is connected to the adjusting structure. The circuit board is provided with a first strip line. The adjusting structure is provided with a second strip line. The gear rack moves to drive the gear to rotate and further drives the arc-shaped internal gear to rotate. The adjusting structure rotates along with the arc-shaped internal gear, such that the second strip line contacts different positions of the first strip line.

Abstract: The present invention relates to a composite current collector and its preparation method, electrodes, and batteries. The composite current collector includes an insulating substrate, a first metal layer set on both surfaces of the thickness direction of the insulating substrate, and a second metal layer set on the surface away from the insulating substrate on the first metal layer. Multiple colloidal particles are attached to the surface of the first metal layer away from the insulating substrate, with the colloidal particles evenly distributed. The second metal layer is set on the first metal layer, and the second metal layer encapsulates the evenly distributed colloidal particles. By setting the composite current collector with specific structures of the colloidal particles, it overcomes the issues of low electrode peel strength and capacity drop in long cycle batteries, significantly enhancing the stability of long cycle battery electrodes.

Abstract: A secondary battery positive electrode material, relating to the field of battery materials. The secondary battery positive electrode material comprises large particles with particle size of ?2 ?m and small particles with particle size of ?1 ?m. The surfaces of some of the small particles are provided with a carbon coating layer; and the surfaces of some of the large particles are not provided with a carbon coating layer. According to the positive electrode material, by means of gradation design of the large and small particles, the compaction density is improved. Moreover, the surfaces of the small particles are coated with a carbon layer to provide sufficient electron transport paths. Additionally, the surfaces of the large particles are not hindered by a carbon coating layer, so that the impedance in a charge and discharge process can be reduced.

Abstract: A top cover for a power battery including a top cover plate, a first post, a first fastener, a second post, a first sealing member, and an insulation plate.

Abstract: A ternary positive electrode material, a method for preparing the same, a positive electrode sheet and a lithium ion battery in which the ternary positive electrode material has a chemical composition of Lia(NixCoyM1-x-y)1-bM?bO2-cAc, wherein 0.75?a?1.2, 0.5?x<1, 0<y?0.1, 0?b?0.01, 0?c?0.2; M is at least one selected from the group consisting of Mn and Al; M? is at least one selected from the group consisting of Al, Zr, Ti, Y, Sr, W and Mg; A is at least one selected from the group consisting of S, F and N; and 2%?CCo1?CCo, 5%?CAl?CAl1. The lithium ion battery shows better short-term kinetic performances and long-term kinetic performances, and it also exhibits excellent stability in long-term cycles.

Abstract: A sewage purification treatment apparatus capable of being assembled in a prefabricated way includes a treatment table, an aeration tank, a filter tank, a water pump, a dosing assembly, a filtering assembly, a cleaning assembly and a washing assembly, the aeration tank and the filter tank are disposed at the top of the treatment table at an interval, an aeration plate is disposed at the bottom end of the inside of the aeration tank. The cleaning assembly works with the filtering assembly to automatically clean the screen in the filtering assembly to prevent impurities from blocking the screen, meanwhile, the screen can be automatically moved out of the filter tank for easy replacement, which is very convenient.

Abstract: A method and associated device, the method including: obtaining the state of charge of a replacement module, and obtaining the state of charge of a main circuit battery by the state of charge of the replacement module, wherein the replacement module replaces an original battery and the capacity of the replacement module is greater than the original battery, and the original battery is connected in series with the main circuit battery in a lithium iron phosphate battery branch of the battery system; conducting self-discharge detection on the replacement module and the main circuit battery, and carrying out balance control when the replacement module or the main circuit battery has a large self-discharge; and after balance control, determining an updated state of charge of the replacement module, and updating the state of charge of the main circuit battery according to the updated state of charge of the replacement module.

Abstract: The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.