Abstract: The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.

Abstract: An apparatus for stripping metal sheets from a cathode blank includes: a frame; a stripping assembly disposed on the frame; and a receiving mechanism including at least one receiving platform which is disposed on the frame for receiving the deposited metal sheets. The stripping assembly includes: first and second clipping mechanisms for clipping a conductive member on an upper end of the cathode blank; first and second stripping mechanisms for stripping the deposited metal sheets from two surfaces of the cathode blank; a bottom positioning mechanism for positioning a lower end of the cathode blank; and first and second loosening mechanisms each including a push rod which is movably disposed on the frame in the transversal direction for pushing the cathode blank.

Abstract: Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (?-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.

Abstract: In one embodiment, packet flows are distributed among groups, such as, but not limited to, queues or links. For example in the context of a bundled interface in which multiple links appear as a single logical interface on each of the sender and receiver, packet flows are distributed among these multiple links by the sender. When one or more links become unavailable, packet flows of the affected links are reassigned to other active links, while packet flows assigned to the unaffected links remain associated with the same link in contrast to prior systems which do not attempt to preserve prior associations between packet flows and links. By maintaining these associations, the receiver of the packets does not need to adjust to the different arrival links of packet flows.

Abstract: A transverse adjustment mechanism for a bilateral half-spring type load-carrying head is installed in the casing of the load-carrying head of the lifting unit of a pit type unwheeling machine, fixedly connected with the casing, directly connected to an adjustment unit at the end of the load-carrying head, and installed on a lead screw of the adjustment unit. The transverse adjustment mechanism includes an adjusting nut, an adjusting nut guide, a guiding tube, and a guiding sleeve, a nut mounting plate, a flange plate, a compression spring and a sliding shaft. The invention is currently applied to the transverse adjustment of the no-loading heads and transverse fine adjustment of the load-carrying heads of the CRH train. The structure is reliable and practical, safe, convenient and energy-saving to use and satisfies the demand for the synchronous lifting operation of the entire CRH train of the compatible pit type unwheeling machine.

Abstract: The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.

Abstract: An apparatus for stripping metal sheets from a cathode blank comprises: a frame; a stripping assembly disposed on the frame; and a receiving mechanism comprising at least one receiving platform which is disposed on the frame for receiving the deposited metal sheets. The stripping assembly comprises: at least one clipping mechanism for clipping a conductive member on an upper end of the cathode blank; first and second stripping mechanisms for stripping the deposited metal sheets from two surfaces of the cathode blank; a bottom positioning mechanism for positioning a lower end of the cathode blank; and first and second loosening mechanisms each comprising a push rod which is movably disposed on the frame in the transversal direction for pushing the cathode blank.

Abstract: In one embodiment, packet flows are distributed among groups, such as, but not limited to, queues or links. For example in the context of a bundled interface in which multiple links appear as a single logical interface on each of the sender and receiver, packet flows are distributed among these multiple links by the sender. When one or more links become unavailable, packet flows of the affected links are reassigned to other active links, while packet flows assigned to the unaffected links remain associated with the same link in contrast to prior systems which do not attempt to preserve prior associations between packet flows and links. By maintaining these associations, the receiver of the packets does not need to adjust to the different arrival links of packet flows.

Abstract: The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.

Abstract: A programmable logic device (PLD) with a programmable logic core, block memory, and I/O circuitry has one or more blocks of standard-cell logic (SLBs) that are integrated into the PLD design to enable each SLB to be programmably connected to any one or more of the programmable core, the block memory, and/or the I/O circuitry. The addition of standard-cell-based functional blocks creates a PLD with increased overall logic density, a net smaller die size per function, lowered cost, and improvements to both power and performance characteristics relative to equivalent conventional PLDs, such as FPGAs.

Abstract: A programmable logic device (PLD) with a programmable logic core, block memory, and I/O circuitry has one or more blocks of standard-cell logic (SLBs) that are integrated into the PLD design to enable each SLB to be programmably connected to any one or more of the programmable core, the block memory, and/or the I/O circuitry. The addition of standard-cell-based functional blocks creates a PLD with increased overall logic density, a net smaller die size per function, lowered cost, and improvements to both power and performance characteristics relative to equivalent conventional PLDs, such as FPGAs.

Abstract: A programmable logic device (PLD) with a programmable logic core, block memory, and I/O circuitry has one or more blocks of standard-cell logic (SLBs) that are integrated into the PLD design to enable each SLB to be programmably connected to any one or more of the programmable core, the block memory, and/or the I/O circuitry. The addition of standard-cell-based functional blocks creates a PLD with increased overall logic density, a net smaller die size per function, lowered cost, and improvements to both power and performance characteristics relative to equivalent conventional PLDs, such as FPGAs.