Abstract: The present disclosure relates to the field of biomedicine, in particular to the use of MCM8-cGAS-STING-IFN-I signal pathway as a disease target, including the use in the preparation of an animal model of a disease or the preparation of a product for the diagnosis, prevention, or treatment of a disease. In particular, the present disclosure comprises the use of a reagent for quantitatively detecting the gene expression or protein expression or protein activity of MCM8 in the preparation of a product for the diagnosis of a disease caused by dysfunctional mitophagy or caused by abnormal activation of cGAS-STING-IFN-I signaling pathway.

Abstract: A method for positioning an underwater glider based on a virtual TDOA of a single beacon is provided. In the method, a positioning beacon periodically sends positioning messages, where the positioning message includes longitude, latitude and depth information of the positioning beacon; the underwater glider receives the positioning messages and records TOAs at which the positioning messages arrive at an acoustic positioning signal receiving module; and the underwater glider parses the positioning messages and stores positioning message data, creates virtual beacons based on beacon information and attitude information of the underwater glider, corrects the TOAs, and calculates a position of the underwater glider according to a TDOA algorithm. According to the method, the underwater glider passively listens to and receives the positioning messages without sending a positioning request to the positioning beacon, making the entire positioning process energy-saving with a certain degree of concealment.

Abstract: The present disclosure provides a method for optimizing a protograph-based LDPC code over an underwater acoustic (UAW) channel. The traditional protograph-based LDPC code over an UAW channel does not consider performance in an error floor region. The method first determines parameters such as a protograph-based LDPC code length, a basic protograph, a target decoding threshold, a threshold adjustment factor, and an ACE check parameter. The protograph is optimized, and the method constructs a parity check matrix by using a UAW channel-based PEG/ACE hybrid algorithm, performs ACE check on the parity check matrix, and calculates a decoding threshold for the matrix passing the check. If the decoding threshold is within a range of an iterative decoding threshold, the parity check matrix is a final optimized matrix. Otherwise, the method continues to optimize the protograph until a parity check matrix passing the check is obtained.

Abstract: A method for positioning an underwater glider based on a virtual TDOA of a single beacon is provided. In the method, a positioning beacon periodically sends positioning messages, where the positioning message includes longitude, latitude and depth information of the positioning beacon; the underwater glider receives the positioning messages and records TOAs at which the positioning messages arrive at an acoustic positioning signal receiving module; and the underwater glider parses the positioning messages and stores positioning message data, creates virtual beacons based on beacon information and attitude information of the underwater glider, corrects the TOAs, and calculates a position of the underwater glider according to a TDOA algorithm. According to the method, the underwater glider passively listens to and receives the positioning messages without sending a positioning request to the positioning beacon, making the entire positioning process energy-saving with a certain degree of concealment.

Abstract: The present disclosure provides a method for optimizing a protograph-based LDPC code over an underwater acoustic (UAW) channel. The traditional protograph-based LDPC code over an UAW channel does not consider performance in an error floor region. The method first determines parameters such as a protograph-based LDPC code length, a basic protograph, a target decoding threshold, a threshold adjustment factor, and an ACE check parameter. The protograph is optimized, and the method constructs a parity check matrix by using a UAW channel-based PEG/ACE hybrid algorithm, performs ACE check on the parity check matrix, and calculates a decoding threshold for the matrix passing the check. If the decoding threshold is within a range of an iterative decoding threshold, the parity check matrix is a final optimized matrix. Otherwise, the method continues to optimize the protograph until a parity check matrix passing the check is obtained.

Abstract: A process for making activated carbon monolith using PTFE as binder is disclosed and described. The process includes carbon-PTFE paste preparation, shearing the paste in a calender with hot rollers, and forming carbon monoliths using compression shaping equipment.

Abstract: Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by preconditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment ha the effect of decreasing apoptosis/necrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.

Abstract: Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by preconditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment ha the effect of decreasing apoptosis/necrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.

Abstract: Flavone analogues of formula ##STR1## wherein; X is O or S;R.sub.1 is C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl or R.sub.2 O is a sugar residue;R.sub.3 is H, C.sub.1 -C.sub.6 alkyl or R.sub.3 O is a sugar residue;R.sub.4 is H, OH, or a sugar residue;R.sub.5 is H, C.sub.1 -C.sub.6 alkyl, or R.sub.5 O is a sugar residue;m is an integer of 1 or 2; andn is an integer from 0 to 5,are useful as anti-rejection agents in organ transplants.