Abstract: Some embodiments of the present disclosure provide a Light Emitting Diode (LED) lamp cap, the LED lamp cap includes a metal casing and an adjusting part, the adjusting part includes an adjusting member disposed on the upper part of the metal casing and a connecting part disposed in the metal casing, the adjusting member is connected with a switch through the connecting part, and the connecting part is configured for rotating by rotating the adjusting member so as to change a gear of the switch to adjust color temperature or brightness or timing or sensing of an LED light source.

Abstract: The invention is directed to composition and methods for the diagnosis, treatment and prevention of various disorders including but not limited to cancer and neurological disorders. In particular, the invention is directed to compositions and methods for the inhibition of PC4.

Abstract: Some embodiments of the present disclosure provide a Light Emitting Diode(LED) lamp cap, the LED lamp cap includes a metal casing and an adjusting part, the adjusting part includes an adjusting member disposed on the upper part of the metal casing and a connecting part disposed in the metal casing, the adjusting member is connected with a switch through the connecting part, and the connecting part is configured for rotating by rotating the adjusting member so as to change a gear of the switch to adjust color temperature or brightness or timing or sensing of an LED light source.

Abstract: Disclosed herein are de-bondable polyurethane adhesives based on thermally expandable microspheres, obtainable or obtained by the reaction of the components of (A) at least one di- or polyisocyanate, (B) at least one polyol, (C) catalyst, (D) thermally expandable microspheres, and (E) other additives, wherein the isocyanate index of the reaction is set in the range of from 28 to 65. Additionally disclosed herein is a method of using the de-bondable polyurethane adhesives for de-bonding metal and cutting pad during wafer cutting. Further disclosed herein is a method of using the de-bondable polyurethane adhesives in mechanical property testing sample preparation.

Abstract: Disclosed in the present invention are a pyrazolone-fused pyrimidine compound, and a preparation method and a use therefor. Provided in the present invention is a pyrazolone-fused pyrimidine compound as in formula (I), said compound having better inhibitory activity towards WEE1 kinase.

Abstract: Disclosed are a pyrazolone-fused pyrimidine compound, a preparation method for same and applications thereof. Provided in the present invention is the pyrazolone-fused pyrimidine compound as represented by formula (II). The compound has improved inhibitory activity with respect to WEE1 kinase.

Abstract: Described herein is a feminine hygiene absorbent article, including: (A) an upper liquid-pervious layer, (B) a lower liquid-impervious layer, (C) a fluid-absorbent core between the layer (A) and the layer (B), including 5% to 50% by weight of water-absorbent polymer particles G and not more than 95% by weight of fibrous material, based on the sum of water-absorbent polymer particles G and fibrous material; (D) an optional acquisition-distribution layer between (A) and (C), (E) an optional tissue layer disposed immediately above and/or below (C); and (F) other optional components, where the water-absorbent polymer particles G are obtainable by agglomerating a blend of non-surface post-crosslinked fine water-absorbent polymer particles and surface post-crosslinked fine water-absorbent polymer particles, and drying, grinding, sieving and classifying the agglomerated water-absorbent polymer particles.

Abstract: Described herein is a fluid-absorbent core including at least two layers, an upper layer and a lower layer, each layer including from 0 to 10% by weight fibrous material and from 90 to 100% by weight water-absorbent polymer particles, based on the sum of water-absorbent polymer particles and fibrous material, where within the upper layer (91) is a water absorbent mixture including at least 10% by weight of a first type of water-absorbent polymer particles, water-absorbent polymer particles G, with a vortex of less than 30 s and at least 50% by weight of a second type of water-absorbent polymer particles, water-absorbent polymer particles H, with a CRC of at least 25 g/g. Also described herein is a fluid-absorbent article including the fluid-absorbent core.

Abstract: The invention is directed to composition and methods for the diagnosis, treatment and prevention of various disorders including but not limited to cancer and neurological disorders. In particular, the invention is directed to compositions and methods for the inhibition of PC4.

Abstract: The present invention discloses a substituted pyridine compound represented by formula I, and a pharmaceutically acceptable salt, stereoisomer and tautomer thereof. The compounds of the present invention are useful in the treatment of cancers.

Abstract: A heterodyne optical spectroscopy system comprises a light source that acts as a local oscillator (LO); a beam splitting component that generates a reference beam from the LO; a signal component that generates a sample signal from a sample; a beam blocker that can turn off the sample signal to generate blank shots; a composite signal detection subsystem that detects a heterodyned signal that is a mix of the sample signal and a portion of the LO; a composite reference detection subsystem synchronized to the signal detection subsystem to detect a portion of the reference beam; and a processor that processes digital signals from the signal detection subsystem and the reference detection subsystem. A very versatile reference scheme is developed to treat different heterodyne spectroscopies in a unified way, which achieves optimal noise suppression.

Abstract: The present invention discloses a substituted pyridine compound represented by formula I, and a pharmaceutically acceptable salt, stereoisomer and tautomer thereof. The compounds of the present invention are useful in the treatment of cancers.

Abstract: The present invention discloses a nitrogen-containing fused heterocyclic compound, as well as a preparation method, intermediate, composition and application thereof. The nitrogen-containing fused heterocyclic compound of the present invention as represented by formula (I), as well as the pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, metabolite or drug precursor thereof, exhibit a high selectivity and a high inhibitory activity with respect to CDK4 and CDK6 at a molecular level, an excellent inhibitory activity with respect to breast cancer cells at a cellular level, and significant inhibition of tumor cell proliferation associated with cyclin-dependent kinase activity at an animal level. The invention also exhibits a good stability with respect to human or mouse liver microsomes without significant inhibition of metabolic enzymes, good in vivo absorption in mice and rats, a high bioavailability and good druggability.

Abstract: The present invention discloses a nitrogen-containing fused heterocyclic compound, as well as a preparation method, intermediate, composition and application thereof. The nitrogen-containing fused heterocyclic compound of the present invention as represented by formula (I), as well as the pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, metabolite or drug precursor thereof, exhibit a high selectivity and a high inhibitory activity with respect to CDK4 and CDK6 at a molecular level, an excellent inhibitory activity with respect to breast cancer cells at a cellular level, and significant inhibition of tumor cell proliferation associated with cyclin-dependent kinase activity at an animal level. The invention also exhibits a good stability with respect to human or mouse liver microsomes without significant inhibition of metabolic enzymes, good in vivo absorption in mice and rats, a high bioavailability and good druggability.

Abstract: A heterodyne optical spectroscopy system comprises a light source that acts as a local oscillator (LO); a beam splitting component that generates a reference beam from the LO; a signal component that generates a sample signal from a sample; a beam blocker that can turn off the sample signal to generate blank shots; a composite signal detection subsystem that detects a heterodyned signal that is a mix of the sample signal and a portion of the LO; a composite reference detection subsystem synchronized to the signal detection subsystem to detect a portion of the reference beam; and a processor that processes digital signals from the signal detection subsystem and the reference detection subsystem. A very versatile reference scheme is developed to treat different heterodyne spectroscopies in a unified way, which achieves optimal noise suppression.

Abstract: The present invention relates to cleaning composition, preferably a laundry detergent composition, comprising a cationic polymer capable of improving the overall sudsing profile of such cleaning composition.

Abstract: A method for improving sudsing profile of laundry detergent compositions with a cationic polymer. Related liquid detergent compositions having a cationic polymer. The cationic polymer may be characterized by having a weight average molecular weight (Mw) ranging from 1,000 to 300,000 Daltons and by containing: (i) from 35 mol % to 85 mol % of a first, nonionic structural unit derived from (meth)acrylamide (AAm); (ii) from 10 mol % to 65 mol % of a second, cationic structural unit; and (iii) from 0.1 mol % to 35 mol % of a third, anionic structural unit derived from (meth)acrylic acid (AA) or anhydride thereof, while the total mol % of (i)-(iii) adds up to 100 mol %, and the molar ratio of (ii) to (iii) is greater than 1.

Abstract: The present invention relates to cleaning composition, preferably a laundry detergent composition, comprising a cationic polymer capable of improving the overall sudsing profile of such cleaning composition.

Abstract: The present invention relates to a method for selecting features of EEG signals based on a decision tree: firstly, acquired multi-channel EEG signals are pre-processed, and then the pre-processed EEG signals are performed with feature extraction by utilizing principal component analysis, to obtain a analysis data set matrix with decreased dimensions; superior column vectors are obtained through analyzing from the analysis data set matrix with decreased dimensions by utilizing a decision tree algorithm, and all the superior column vectors are jointed with the number of the columns increased and the number of the rows unchanged, to be reorganized into a final superior feature data matrix; finally, the reorganized superior feature data matrix is input to a support vector machine (SVM) classifier, to perform a classification on the EEG signals, to obtain a classification accuracy.

Abstract: Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional positive factor 4 (PC4). Also provided are methods of screening for cancer inhibition agents based on inhibition of PC4 expression or function.