Abstract: Use of a mulberry extract in the preparation of a product for treating and/or improving polycystic ovarian syndrome. It is demonstrated in the experiment that the mulberry twig alkaloids can reduce the ovarian weight of rats with polycystic ovarian syndrome and improve the ovarian pathology, regulate the estrous cycle of rats with polycystic ovarian syndrome in the intervention process, and can remarkably adjust the secretion level of sex hormones in rats with polycystic ovarian syndrome.

Abstract: A circuit includes a first transistor, a second transistor, and a resistor. The first transistor is coupled between a switch voltage input and a switch voltage output. The first transistor has a first control terminal. The second transistor is coupled between the switch voltage input and the first control terminal. The second transistor has a second control terminal coupled to a low-power mode terminal. The resistor is coupled in series with the second transistor between the first control terminal and the switch voltage input.

Abstract: A transistor is coupled between a first voltage input and a voltage output in a first current path. First circuitry is coupled to a second voltage input, a control terminal of the transistor, and the voltage output. Second circuitry is coupled between the control terminal and ground in a second current path and between the control terminal and ground in a third current path parallel to the second current path. The second current path includes the control terminal, first and second terminals of the second circuitry, and ground. The third current path includes the control terminal, a second and the third terminal of the second circuitry, and ground. Third circuitry is coupled between the control terminal and the voltage output in a fourth current path. The fourth current path includes the control terminal, first and second terminals of the third circuitry, and the voltage output.

Abstract: Aspects of the disclosure relate to methods for analyzing compositions comprising RNA species with unique nucleotide sequences for identification and/or ratio determination of RNAs. The disclosure is based, in part, on methods of cleaving identifying sequences from RNAs in a composition, and detecting the abundance of each identifying sequence to quantify the abundance of corresponding RNA species. Other aspects relate to methods for producing compositions comprising more than two RNA species, such as multivalent RNA compositions. The disclosure is based, in part, on methods of determining the proper amount of input DNA for in vitro transcription (IVT) reactions that will result in RNA being transcribed in a predetermined ratio. In some aspects, the disclosure relates to pharmaceutical compositions comprising multivalent RNA compositions produced by methods described, by the disclosure.

Abstract: Novel methods for identification and analysis of mRNA are provided herein. The methods may involve digestion and fingerprinting analysis.

Abstract: A suspension frame assembly of a magnetic levitation vehicle, includes multiple suspension frames which are sequentially connected; and each suspension frame includes two longitudinal beam bodies arranged in parallel. A supporting wheel and a holding arm are fixedly provided on both ends of each longitudinal beam body; and two anti-rolling devices mounted between mounting frames of two of the supporting wheels at a same end of the two longitudinal beam bodies; and the two longitudinal beam bodies of one of the suspension frames are respectively hingedly connected to the two longitudinal beam bodies of an adjacent suspension frame; an air-spring arm beam is provided at a hinged part of the two suspension frames, and is mounted on the holding arm of one of the two longitudinal beam bodies which are hingedly connected.

Abstract: In some examples, a converter circuit can be configured to operate in a buck-boost mode. The converter circuit can include a ramp generator that can be configured to generate first and second ramp signals that at least partially overlap respective portions of a buck-boost region during each intermediate clock cycle between clock cycles of a clock signal. By generating the first and second ramp signals during each intermediate clock cycle, first and second drivers can be provided to toggle switches of a power stage, such that an output voltage provided by the power stage can be averaged out over clock cycles of the clock signal to allow for a gradual transition between buck and boost modes of operation of the converter circuit. In some examples, the converter circuit can be configured to operate in a test mode and can be configured to implement trimming of a ramp signal.

Abstract: In some examples, a converter circuit can be configured to operate in a buck-boost mode. The converter circuit can include a ramp generator that can be configured to generate first and second ramp signals that at least partially overlap respective portions of a buck-boost region during each intermediate clock cycle between clock cycles of a clock signal. By generating the first and second ramp signals during each intermediate clock cycle, first and second drivers can be provided to toggle switches of a power stage, such that an output voltage provided by the power stage can be averaged out over clock cycles of the clock signal to allow for a gradual transition between buck and boost modes of operation of the converter circuit. In some examples, the converter circuit can be configured to operate in a test mode and can be configured to implement trimming of a ramp signal.

Abstract: Embodiments of the present disclosure disclose a method and an apparatus. The apparatus includes interface circuitry and processing circuitry. The processing circuitry obtains attribute information of multimedia information associated with a multimedia provider. The attribute information includes website information of a website used to display the multimedia information and identifier (ID) information associated with the multimedia information. The processing circuitry generates a machine-readable identification code to be scanned by a user device of a user based on at least the website information. Based on the ID information, the processing circuitry obtains a first image corresponding to the multimedia information. The processing circuitry determines an image area in the first image in which the machine-readable identification code is to be inserted. The processing circuitry inserts the machine-readable identification code into the image area to generate a second image.

Abstract: A suspension frame assembly of a magnetic levitation vehicle, which includes: multiple suspension frames which are sequentially connected; and each suspension frame includes: two longitudinal beam bodies arranged in parallel, wherein a supporting wheel and a holding arm are fixedly provided on both ends of each longitudinal beam body; and two anti-rolling devices mounted between mounting frames of two of the supporting wheels at a same end of the two longitudinal beam bodies; and the two longitudinal beam bodies of one of the suspension frames are respectively hingedly connected to the two longitudinal beam bodies of an adjacent suspension frame; an air-spring arm beam is provided at a hinged part of the two suspension frames, and is mounted on the holding arm of one of the two longitudinal beam bodies which are hingedly connected.

Abstract: Embodiments of the present disclosure disclose a method and an apparatus. The apparatus includes interface circuitry and processing circuitry. The processing circuitry obtains attribute information of multimedia information associated with a multimedia provider. The attribute information includes website information of a website used to display the multimedia information and identifier (ID) information associated with the multimedia information. The processing circuitry generates a machine-readable identification code to be scanned by a user device of a user based on at least the website information. Based on the ID information, the processing circuitry obtains a first image corresponding to the multimedia information. The processing circuitry determines an image area in the first image in which the machine-readable identification code is to be inserted. The processing circuitry inserts the machine-readable identification code into the image area to generate a second image.

Abstract: The disclosure discloses a method for querying group's dispatching area information, which comprises: a user sending a request for querying group's dispatching area information to a base station through a user terminal; and the base station querying the group's dispatching area information according to request for querying the group's dispatching area information, and returning a response to the group's dispatching area information query to the user terminal. The disclosure also discloses a query system for the querying group's dispatching area information correspondingly. The present invention can improve the validity, the dispatching reliability and accuracy of the group call.

Abstract: Methods for producing proteins and glycoproteins in Pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant Pichia pastoris strains that do not display a ?-mannosyltransferase 2 activity with respect to an N-glycan or O-glycan and do not display at least one activity selected from a ?-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins. These recombinant Pichia pastoris strains can produce proteins and glycoproteins that lack detectable ?-mannosidase resistant ?-mannose residues thereon and thus, lack cross binding activity to antibodies against host cell antigens. Further described are methods for producing bi-sialylated human erythropoietin in Pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens.

Abstract: Methods for producing proteins and glycoproteins in Pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant Pichia pastoris strains that do not display a ?-mannosyltransferase 2 activity with respect to an N-glycan or O-glycan and do not display at least one activity selected from a ?-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins. These recombinant Pichia pastoris strains can produce proteins and glycoproteins that lack detectable ?-mannosidase resistant ?-mannose residues thereon and thus, lack cross binding activity to antibodies against host cell antigens. Further described are methods for producing bi-sialylated human erythropoietin in Pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens.

Abstract: The disclosure discloses a method for querying group's dispatching area information, which comprises: a user sending a request for querying group's dispatching area information to a base station through a user terminal; and the base station querying the group's dispatching area information according to request for querying the group's dispatching area information, and returning a response to the group's dispatching area information query to the user terminal. The disclosure also discloses a query system for the querying group's dispatching area information correspondingly. The present invention can improve the validity, the dispatching reliability and accuracy of the group call.

Abstract: Methods for producing proteins and glycoproteins in Pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant Pichia pastoris strains that do not display a ?-mannosyltransferase 2 activity with respect to an N-glycan or O-glycan and do not display at least one activity selected from a ?-mannosyltransferase 1, 3, and 4 activity to produce recombinant proteins and glycoproteins. These recombinant Pichia pastoris strains can produce proteins and glycoproteins that lack detectable ?-mannosidase resistant ?-mannose residues thereon and thus, lack cross binding activity to antibodies against host cell antigens. Further described are methods for producing bi-sialylated human erythropoietin in Pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens.

Abstract: Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of Pichia pastoris glycoengineered to produce a GCSF wherein greater than 18% of the molecules comprise an 0-glycan with one mannose per (0-glycan is described. In particular aspects, the GCSF is PEGylated at the JV-terminus.

Abstract: An output stage for an LED driver is provided. In particular, a low voltage clamp, which uses several cascode circuits, is provided to protect low voltage switching transistors in the range of two times higher voltage application under both normal and fault conditions. Additionally, a circuit for regulating the bias voltage applied to each of the cascode circuits is provided to prevent damage during startup, while an internal voltage regulator is settling.

Abstract: A circuit for independently controlling slew and propagation delay of a current DAC is provided. The circuit applies dual slope technique with feed-back control the gate (or control electrode) of a switching transistor to make propagation delay independent control from rise/fall slew rate. This allows one to adjust propagation delay and current slew rate separately to achieve better performance.

Abstract: In a method and system for sensing current in a switching regulator (SWR) operating in a current mode, a power switch is coupled to receive the current from a switching element, the power switch being controlled by a gate signal. An inrush of the current causes an initial transient spike (ITS). A buffer having a buffer input and a buffer output is coupled to receive the gate signal and provide a buffered gate signal. The buffer output is disabled during the ITS. A sense switch (SW) is coupled to receive a portion of the current from the switching element, the SW being turned on by the buffered gate signal after the initial transient spike. A sense resistor (SR) is coupled to receive the portion of the current from the SW. An amplifier converts the portion of the current through the SR to a voltage signal for controlling the SWR.