Abstract: The present invention encompasses engineered nucleases which recognize and cleave a recognition sequence within the first exon of the human T cell receptor (TCR) alpha constant region gene. The engineered meganucleases can exhibit at least one optimized characteristic, such as enhanced (i.e., increased) specificity or efficiency of cleavage, when compared to the first-generation meganuclease TRC 1-2x.87EE. The present invention also encompasses methods of using such engineered nucleases to make genetically-modified cells, and the use of such cells in a pharmaceutical composition and in methods for treating diseases, such as cancer.

Abstract: A positioning method, a device, a system, a terminal, an LMF entity, and a medium, used to solve the problem of low positioning accuracy of UE-based OTDOA in the prior art.

Abstract: A light-regulating mechanism comprising a first ball head connector, a second ball head connector, a third ball head connector and a sliding connector. One end of the first ball head connector and one end of the second ball head connector are connected to an illumination unit. The other ends thereof are connected to a supporting frame or a light body. The illumination unit is provided with a sliding support. The sliding connector can slide on the sliding support. One end of the third ball head connector is connected to the sliding connector in a sliding manner, and the other end thereof can move on the supporting frame or the light body to drive the sliding connector to slide on the sliding support, so that light regulation in a first direction is realized. Further disclosed are a vehicle light module comprising the light-regulating mechanism, a vehicle light and a vehicle.

Abstract: A liquid crystal display panel includes an array substrate and an opposite substrate that are disposed opposite to each other; the liquid crystal display panel has a display region and at least one non-display region disposed beside the display region. The array substrate is of a multi-layer structure and includes a pixel electrode layer and a plurality of protrusions disposed in the at least one non-display region, and the opposite substrate includes a common electrode layer. A protrusion has a structure including at least one film, and a film of the at least one film is located in a layer included in the array substrate.

Abstract: A foldable treadmill includes a running belt and a running board module that includes a first running board sub-module and a second running board sub-module symmetrically arranged on both sides of an intermediate running board sub-module. Two groups of folding connection assemblies are symmetrically arranged on both sides of a center line along a width direction of the running belt. A first connection part is coupled to the first running board sub-module and the intermediate running board sub-module, and a second connection part is coupled to the second running board sub-module and the intermediate running board sub-module. A motion part drives the first running board sub-module to rotate relative to the intermediate running board sub-module through the first connection part, and drives the second running board sub-module to rotate relative to the intermediate running board sub-module through the second connection part, to fold or unfold the foldable treadmill.

Abstract: The present invention relates to protein kinase C beta II inhibiting compounds of Formula (A): wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. The invention further relates to pharmaceutical compositions comprising the compounds of Formula (A), or pharmaceutically acceptable salts thereof, and methods for treating a disease or disorder selected from the group consisting of Alzheimer's disease, cancer, a cardiovascular disease, a central nervous system disorder, depression, a dermatological disease, diabetes mellitus, a complication arising from diabetes mellitus, a disease in which the liver is a target organ inflammation, an inflammatory disorder, ischemia, and a viral disease.

Abstract: An exemplary laser light source system of a modular high-efficiency heat-dissipation uniform field is described. The light beam emitted by the blue laser light source is incident to the reflecting-blue transmitting-yellow beam combining mirror after passing through the scattering plate, and then is incident to the fluorescent unit through the lens group. The light beam generated after the excitation of the fluorescent unit is incident to the light pipe through the lens group I, the reflecting-blue transmitting-yellow beam combining mirror, the reflecting-red transmitting-blue-green beam combining mirror and the lens group II in sequence. The laser light source system of a modular high-efficiency heat-dissipation uniform field can effectively dissipate the heat generated by the laser, and obtain uniform picture projection output at the same time, which has a good practical application value.

Abstract: A short circuit protection circuit may comprise a first configuration channel line extending from a first connector, a first resistor connected to the first configuration channel line; a voltage divider connected to a junction point on the first configuration channel line, the voltage divider comprising a second resistor and a thermistor, and a field effect transistor (FET) comprising a source, gate, and drain. The thermistor may be connected to a ground line. The drain of the FET may be connected to the first resistor, the source of the FET may be connected to the ground line, and the gate of the FET may be connected to a second junction point between the second resistor and thermistor of the voltage divider.

Abstract: The present invention relates to the technical field of vehicle illumination and, in particular, relates to a vehicle lamp optical element assembly, a vehicle lamp comprising the vehicle lamp optical element assembly, and an automobile comprising the vehicle lamp. The vehicle lamp optical element assembly comprises a primary optical element assembly and a secondary optical element assembly, wherein the primary optical element assembly comprises a primary optical element and a first support for supporting the primary optical element, and the secondary optical element assembly comprises a secondary optical element and a second support for supporting the secondary optical element, wherein the first support and the second support are connected in a matching manner so as to enable the primary optical element and the secondary optical element to be relatively fixed.

Abstract: A Lamb wave resonator includes a piezoelectric material layer, a first finger electrode, a second finger electrode, at least two floating electrodes, and at least two gaps. The first finger electrode is disposed on one side of the piezoelectric material layer and includes a first main portion and first fingers. The second finger electrode is disposed on the side of the piezoelectric material layer and includes a second main portion and second fingers. The first fingers are parallel to and alternately arranged with the second fingers. The floating electrodes are disposed between each first finger and each second finger, and the gaps are disposed at two ends of each floating electrode, respectively.

Abstract: A curved screen and a display device are disclosed. The curved screen includes a first substrate, a second substrate, and a liquid crystal layer disposed between the first and second substrates. The curved screen is bent and concave along the first substrate. The first substrate includes a substrate and a planarization layer disposed on a concave side of the substrate. A plurality of grooves are defined in the planarization layer and arranged at intervals along a direction of a bending edge of the curved screen, and extend in parallel along a direction of a non-bending edge. The depth of each groove before bending is greater than after bending.

Abstract: A drilling device for geotechnical engineering investigation is provided, including an outer supporting ring seat, where a center of the outer supporting ring seat is rotatably connected with a middle supporting ring seat through a first supporting shaft rod; a center of the middle supporting ring seat is rotatably connected with an inner supporting ring seat through a second supporting shaft rod; the first supporting shaft rod and the second supporting shaft rod are vertically crossed; a second rotating motor is fixedly installed at one end of the first supporting shaft rod on an outer surface of the outer supporting ring seat; a pow output end of the second rotating motor is fixedly connected with the first supporting shaft rod, an other end of the first supporting shaft rod is provided with a first locking mechanism for position limitation.

Abstract: An encryption and decryption system is provided, which includes a transmitting device and a receiving device. The transmitting device is configured to store original images and a correspondence table. The receiving device is connected to the transmitting device for storing the correspondence table, wherein the transmitting device generates an encrypted string. The transmitting device selects a representative morphed image from multiple morphed images according to the encrypted string. The transmitting device transmits the representative morphed image to the receiving device and does not transmit the encrypted string to the receiving device. The receiving device recognizes the first original image serial number and the second original image serial number from the representative morphed image. The receiving device looks up the correspondence table according to the first original image serial number and the second original image serial number to generate the encrypted string.

Abstract: Disclosed are a method and device for transmitting a positioning reference signal. The method includes a base station determining a time-frequency resource for sending a PRS according to configuration information of the PRS, mapping a PRS sequence to the time-frequency resource for sending the PRS, and sending the mapped PRS on the time-frequency resource for sending the PRS, wherein the configuration information of the PRS comprises PRS frequency domain resource information; the PRS frequency domain resource information comprises PRS resource element (RE) frequency shift information, and the PRS RE frequency shift information is correlated with a PRS OFDM symbol index value calculated from a PRS occasion.

Abstract: Disclosed is a sorting device configured to sort N numbers with N rounds of sorting processes from a first round sorting process to an Nth round sorting process and obtain N-rounds sort results from a first-round sort result to an Nth-round sort result, wherein at least two pairs of numbers of the N numbers are sorted in each of the N rounds of sorting processes concurrently, a Kth-round sort result is dependent on a (K?1)th-round sort result, the Nth-round sort result is the N numbers in a descending/ascending order, and the N is an integer greater than two. The sorting device includes sorting circuits and duplicating circuits that are selectively used for each of the N rounds of sorting processes. Each sorting circuit is configured to sort two numbers and obtain the collating sequence of the two numbers. Each duplicating circuit is configured to output a number it received.

Abstract: The present application discloses a terminal positioning method and device. In the present application, a positioning server receives positioning measurement information reported by a terminal, acquires downlink-positioning reference signal angle information corresponding to downlink-positioning reference signal resource information reported by a base station, and positions the terminal according to the positioning measurement information reported by the terminal and the downlink-positioning reference signal angle information reported by the base station. The positioning measurement information reported by the terminal includes the downlink-positioning reference signal resource information and a downlink-positioning reference signal measurement corresponding to the downlink-positioning reference signal resource information.

Abstract: Embodiments of the present disclosure provide a method and apparatus for correcting a Tx delay, and a storage medium. The method includes receiving Tx delay (Tx Delay) parameter information transmitted by a transmitting node, and transmitting positioning reference signal configuration information to a receiving node; and correcting a positioning measurement value on the basis of the Tx Delay parameter information, the positioning measurement value being obtained by means of the receiving node measuring, according to the positioning reference signal configuration information, a positioning reference signal transmitted by the transmitting node. In the embodiments of the present disclosure, by using Tx Delay parameter information, the effect of a Tx delay on a time-related positioning measurement value can be eliminated, and the positioning precision is effectively improved.

Abstract: The present invention provides a new architecture of system-on-chip ultrasonic transducer array. It is based on fusion bond of two active wafers which have prefabricated CMOS integrated circuits and CMUT structures; precise thin-down of one wafer to form CMUT monocrystalline silicon membrane; and then to vertically connect CMUT array to CMOS IC layers underneath. This architecture can realize a high-density CMUT array with multiple layers of CMOS devices, such as all supporting CMOS ICs, to achieve a SOC solution. The present invention further provides a manufacturing method for above-mentioned SOC CMUT approach, and this manufacturing process can be realized in both 8 inch and 12-inch wafer manufacturing fabs. The disclosed manufacturing processes are more compatible with existing CMOS process flow, more cost-competitive for mass production.

Abstract: A method and a device for accessing a system information area or a network area are provided. The method includes: receiving, by a terminal, at least one initial access signal (IAS) transmitted from the system information area or the network area; and obtaining, by the terminal, one or more of a subframe boundary, a system bandwidth, a starting frequency and an ending frequency of the system information area or the network area based on the received IAS.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a sensor activation and correlation system. One of the methods includes obtaining information describing a flight plan for implementation. A trigger associated with activating a camera included in an unmanned aerial vehicle (UAV) is determined to be satisfied. Information indicating that the camera is to capture an image is provided to the camera. A first timestamp associated with the image is obtained and stored. Information indicating that the image was captured is received and associated with the obtained first timestamp. Information indicating that the camera captured the image is provided to a user device in communication with the UAV.