Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.

Abstract: A display panel includes a base substrate, a display structure layer located on the base substrate of a display region and including multiple display region metal layers, a touch structure layer, multiple contact pads, and a first inorganic insulating layer. The touch structure layer is located on a side of the display structure layer away from the base substrate. The multiple contact pads are located in the first bezel region, and at least one contact pad includes at least one contact pad metal layer. The first inorganic insulating layer exposes at least part of surfaces of contact pad metal layers of the multiple contact pads away from the base substrate. The contact pad metal layer of the at least one contact pad exposed by the first inorganic insulating layer and one of the multiple display region metal layers of the display structure layer are of a same layer structure.

Abstract: The present disclosure provides a display panel including a display component, an encapsulation structure and a guiding layer. The display component includes an electrode layer. The encapsulation structure is stacked on the display component. The electrode layer is adjacent to the encapsulation structure. The guiding layer is disposed in or on the encapsulation structure, and the guiding layer is connected to the electrode layer of the display component, and the guiding layer is configured to transfer heat generated by the display component to outside when the display component is in a working process.

Abstract: A computer-implemented method, system, and computer program product for identifying application programming interface relationships of a product. Entity information for the product is generated. The entity information identifies a plurality of entities of the product, attributes of the entities, and relationships between the entities. The plurality of entities include application programming interfaces of the product and other entities of the product. The entity information is processed by a graph attention network to identify degrees of relationships between the application programming interfaces and the entities of the product.

Abstract: Disclosed herein is a two-component system for preparing deodorant polyurethane foams, which system includes component A including (b) at least one compound having at least two hydrogen atoms reactive toward isocyanates, (c) optionally chain extender and/or crosslinking agent, (d) blowing agent, (e) catalyst, and (f) optionally auxiliaries and additives, and component B including (a) at least one polyisocyanate, and (g) at least one anhydride. Further disclosed herein are a method of preparing deodorant polyurethane foams by the two-component system and a method of using such polyurethane foams in certain applications.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: A scheduling method and system for the operation of reservoirs to recharge freshwater for repelling saltwater intrusion under changing conditions. Research data of a research area is collected, the research area is generalized, and the river network topology of the area is constructed; the research data acquire the seawater flow data of each station in the research area for N time periods, analyze the correlation between the flow of a predetermined station and the saltwater intrusion and build a seawater flow spatial-temporal evolution model; rainfall data and freshwater runoff of each station are acquired to analyze the variation trends of freshwater flow and hydrological regime of each station and a first ending point and build a freshwater flow spatial-temporal evolution model; and a scheduling model for recharging freshwater for repelling saltwater intrusion is built for simulation, a scheduling method is provided, and a scheduling scheme set is formed.

Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.

Abstract: A computer-implemented method, system, and computer program product for identifying application programming interface relationships of a product. Entity information for the product is generated. The entity information identifies a plurality of entities of the product, attributes of the entities, and relationships between the entities. The plurality of entities include application programming interfaces of the product and other entities of the product.

Abstract: An optical assembly, a camera module having the optical assembly, and a smart device having the camera module.

Abstract: The present invention relates to fused imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.

Abstract: Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.

Abstract: A method for speed prediction may include obtaining current vehicle speeds associated with first vehicles that pass through a target road section in a current time interval. The method may also include determining a current road speed associated with the target road section in the current time interval based on the current vehicle speeds. The method may also include determining a predicted speed difference between the current road speed and a future road speed associated with the target road section in a future time interval based on the current road speed and a trained prediction model, which is based on prior speed differences, wherein the current time interval and the future time interval are separated by a first time period. The method may also include estimating the future road speed based on the predicted speed difference and the current road speed.

Abstract: A method for determining link topology relationships in an on-demand service area is provided. The method may include obtaining one or more historical orders associated with the on-demand service area and determining a sequence of links with respect to each of the one or more historical orders. The method may further include generating one or more link groups regarding each link of the sequence of links associated with the one or more historical orders. Each of the one or more link groups may include the each link and one or more subsequent links of the each link. The method may further include determining link topology relationships based on the one or more link groups.

Abstract: A method for speed prediction may include obtaining current vehicle speeds associated with first vehicles that pass through a target road section in a current time interval. The method may also include determining a current road speed associated with the target road section in the current time interval based on the current vehicle speeds. The method may also include determining a predicted speed difference between the current road speed and a future road speed associated with the target road section in a future time interval based on the current road speed and a trained prediction model, which is based on prior speed differences, wherein the current time interval and the future time interval are separated by a first time period. The method may also include estimating the future road speed based on the predicted speed difference and the current road speed.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An optical assembly, a camera module having the optical assembly, and a smart device having the camera module.

Abstract: The present invention relates to pyrimidine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.