Abstract: The present invention relates to crystal forms of A, B, C, D, E, F and G of selumetinib sulfate and the preparation method thereof. The crystal forms A, B and F of selumetinib sulfate are obtained by adding 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-vinyloxy-ethoxy)-amide (SEL-3) into an organic solvent; further, crystal form A of selumetinib sulfate can be as a raw material to prepare crystal forms C, D and E of selumetinib sulfate, and crystal form C of selumetinib sulfate can be as a raw material to prepare crystal form G of selumetinib sulfate.

Abstract: The present disclosure provides a preparation method of tofacitinib citrate, which comprises the following steps: passing an intermediate TOF-2 into hydrogen at a normal pressure in the presence of a catalyst to obtain an intermediate TOF-3; in the presence of a solvent and a base, under a reduced pressure of ?490 mmHg to ?760 mmHg, and at a temperature of 10° C. to 25° C., reacting TOF-3 with ethyl cyanoacetate to generate an intermediate TOF-4; heating and dissolving TOF-4 and citric acid in a solvent, and performing separation by cooling to obtain tofacitinib citrate. The present disclosure obtains tofacitinib citrate with high yield, high purity and low impurities by changing a gas flow rate and a reaction temperature and pressure of a hydrogenation reaction. Therefore, the preparation method is suitable for industrial production.

Abstract: The present invention relates to a method for removing water from a compound solution and performing conjugate acid conversion. The method uses a nanometer film to perform reverse osmosis for the compound solution to remove water, and provides a conjugate acid to replace the acidic substances in the compound solution in order to obtain compound conjugate acid salts. The method of the present invention can effectively reduce the water content of the compound solution and replace the conjugate acid of the compound to form the desired compound conjugate acid salt.

Abstract: The present invention relates to a method for removing water from a compound solution and performing conjugate acid conversion. The method uses a nanometer film to perform reverse osmosis for the compound solution to remove water, and provides a conjugate acid to replace the acidic substances in the compound solution in order to obtain compound conjugate acid salts. The method of the present invention can effectively reduce the water content of the compound solution and replace the conjugate acid of the compound to form the desired compound conjugate acid salt.

Abstract: Provided is a non-ferromagnetic spacing composite layer, comprising first, second and third spacing layers stacked in sequence. The first and third spacing layers are each made of Re, Rh, Ir, W, Mo, Ta, or Nb, and the second spacing layer is made of Ru. The second spacing layer has a thickness of equal to or more than 0.18 nm, and the non-ferromagnetic spacing composite layer has a total thickness of 0.6 nm to 1 nm. Also, provided are a method of preparing the non-ferromagnetic spacing composite layer, a synthetic antiferromagnetic laminated structure, and an MRAM. The synthetic antiferromagnetic laminated structure can maintain a certain coupling strength and the RKKY indirect interaction after thermal treatment, thereby keeping the recording function of MRAM.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: A light emitting device driver circuit includes: a power conversion circuit, an error amplifier circuit, a sample-and-hold circuit, a load current generation circuit and a feed-forward capacitor. When the light emitting device driver circuit is in a disable phase, the sample-and-hold circuit connects a feedback signal with a second reference voltage and the sample-and-hold circuit disconnects the feedback signal from a load node, whereby the feed-forward capacitor samples a sample voltage and holds it after the disable phase transits to an enable phase. In the enable phase, the sample-and-hold circuit disconnects the feedback signal from the second reference voltage and the sample-and-hold circuit connects the feedback signal with the load node, so that during a predetermined period following the transition, there is a sufficient difference between two input terminals of the error amplifier circuit so that the load current is raised to a desired current level within the predetermined period.

Abstract: A light emitting device driver circuit includes: a power conversion circuit, an error amplifier circuit, a sample-and-hold circuit, a load current generation circuit and a feed-forward capacitor. When the light emitting device driver circuit is in a disable phase, the sample-and-hold circuit connects a feedback signal with a second reference voltage and the sample-and-hold circuit disconnects the feedback signal from a load node, whereby the feed-forward capacitor samples a sample voltage and holds it after the disable phase transits to an enable phase. In the enable phase, the sample-and-hold circuit disconnects the feedback signal from the second reference voltage and the sample-and-hold circuit connects the feedback signal with the load node, so that during a predetermined period following the transition, there is a sufficient difference between two input terminals of the error amplifier circuit so that the load current is raised to a desired current level within the predetermined period.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: A metamaterial is suitable for receiving a detecting wave. The detecting wave interacts with the metamaterial. The metamaterial includes a substrate and at least one unit cell placed on the substrate. The size of the unit cell is at least less than ? of the wavelength of the detecting wave. A biological and chemical detecting system using the metamaterial is also disclosed.

Abstract: A method for attaching a conductive particle to the apex of a probe tip comprises the steps of: moving the apex of a probe tip close to a conductive particle and applying a bias voltage between the probe tip and the conductive particle so that the conductive particle can permanently attach to the apex. The method uses only a bias voltage to transfer and attach conductive particles to the apex of a probe tip, and no surface treatment of the probe tip is required.

Abstract: The preset invention relates to a new method for treating brain tumor with an antipsychotic phenothiazine derivative as a brain tumor cell inhibitor or a brain tumor stem cell inhibitor. In particular, an antipsychotic phenothiazine is accessible to brain via blood-brain barrier, which should be beneficially in treatment of brain tumor.

Abstract: A cobalt-iron alloy sputtering target is made by melting and casting process and consists of cobalt, iron and additive metal, wherein the cobalt has an increased pass through flux content in the cobalt-iron alloy sputtering target and the additive metal has a content from 8 at % 20 at % and is at least one metal selected from the group consisting of tantalum, zirconium, niobium, hafnium, aluminum and chromium. The cobalt-iron alloy sputtering target has increased pass through flux.

Abstract: A method for attaching a conductive particle to the apex of a probe tip comprises the steps of: moving the apex of a probe tip close to a conductive particle and applying a bias voltage between the probe tip and the conductive particle so that the conductive particle can permanently attach to the apex. The method uses only a bias voltage to transfer and attach conductive particles to the apex of a probe tip, and no surface treatment of the probe tip is required.

Abstract: A forecasting system takes advantage of an E-mail system of the internet to forecast different days of a following menstruation period of a woman via different terminals, such as a mobile telephone which supports WAP and a personal computer which is capable of connecting with the internet. The working of the forecasting system includes entering via a terminal relative information of menstruation of a woman, establishing a data base in a data server of the internet depending on the entered information, calculating an ovulation day, impregnable days, starting and ending days of a following menstrual flow of the woman, and sending out inquired forecast information to the woman via the different terminals.

Abstract: A system of watching a person to be diagnosed/treated in time includes a database server; a network server; and a communication devices; wherein the database server is built-in with a database of vaccination and with a software, so that a) the database server determines time for a person to be diagnosed/treated according to medical criteria on his/her medical data recorded in the database; b) said network server and said communication means notify said person to be diagnosed/treated according to the determined time in advance the determined time; and c) said network server and said communication means remind said person of the diagnosis/treatment if said network server should fail to receive a confirmation of his/her diagnosis/treatment after the determined time.

Abstract: A system of watching a person's blood pressure includes a database server; a network server; and a communication devices; wherein the database server is built-in with a database of blood pressure and with a software, so that a) the database server determines time for a person to measure his/her blood pressure according to medical criteria on his/her blood pressure history recorded in the database; b) the network server and the communication device notify the person to measure his/her blood pressure in advance the determined time and report his/her measured blood pressure to the network server according to the determined time; and c) the network server and the communication device remind the person of the blood pressure measurement if the network server should fail to receive his/her measured blood pressure after the determined time.

Abstract: A system of watching a person's blood sugar includes a database server; a network server; and a communication devices; wherein the database server is built-in with a database of blood sugar and with a software, so that a) the database server determines time for a person to measure his/her blood sugar according to medical criteria on his/her blood sugar history recorded in the database; b) the network server and the communication device notify the person to measure his/her blood sugar in advance the determined time and report his/her measured blood sugar to the network server according to the determined time; and c) the network server and the communication device remind the person of the blood sugar measurement if the network server should fail to receive his/her measured blood sugar after the determined time.

Abstract: A system of watching a person to be vaccinated in time includes a database server; a network server; and a communication devices; wherein the database server is built-in with a database of vaccination and with a software, so that a) the database server determines time for a person to be vaccinated according to medical criteria on his/her vaccination history recorded in the database; b) said network server and said communication means notify said person or his/her proxy the determined vaccination time in advance the determined vaccination time; and c) said network server and said communication means remind said person or his/her proxy of the vaccination if said network server should fail to receive a confirmation of his/her vaccination after the determined vaccination time.

Abstract: A hydrogen peroxide destroying composition is disclosed, which includes 1-30% of a hydrogen peroxide destroying component, 0.5-40% of a binder, 0-20% of a disintegrant and 0.02-3% of a chlorophyll coloring agent, based on the weight of the hydrogen peroxide destroying composition. When the hydrogen peroxide destroying composition of the present invention in the form of a tablet or pills added into a H.sub.2 O.sub.2 -containing aqueous medium for disinfecting contact lens, said coloring agent will color the aqueous medium indicating an initiation of neutralization of residual H.sub.2 O.sub.2 caused by the hydrogen peroxide destroying component after a period of time from the addition.