Abstract: The present disclosure relates to Clostridium botulinum neurotoxin serotype A (BoNT/A) compositions with a plurality of 900 kDa Clostridium botulinum neurotoxin serotype A (BoNT/A) complex species. Provided herein are compositions comprising BoNT/A that have a low level of oxidation at specific methionine positions of 150 kDa BoNT/A.

Abstract: The present disclosure relates to Clostridium botulinum neurotoxin serotype A (BoNT/A) compositions with a plurality of 900 kDa Clostridium botulinum neurotoxin serotype A (BoNT/A) complex species. Provided herein are compositions comprising BoNT/A that have a low level of oxidation at specific methionine positions of 150 kDa BoNT/A.

Abstract: The present disclosure provides example wavelength selective switch (WSS), wavefront control element, and integrated liquid crystal on silicon (LCoS). One example WSS includes an input port fiber array, a demultiplexing/multiplexing grating group, an output port fiber array, and a beam deflection component group including two beam deflection components and at least one wavefront control element located between the demultiplexing/multiplexing grating group and the beam deflection component group or integrated with the LCoS. At least one beam deflection component is a LCoS. The input port fiber array receives multi-wavelength optical signals. The demultiplexing/multiplexing grating group demultiplexes and outputs the multi-wavelength optical signals. The beam deflection component group deflects the multi-wavelength optical signals to the demultiplexing/multiplexing grating group. The demultiplexing/multiplexing grating group multiplexes the multi-wavelength optical signals to the output port fiber array.

Abstract: Provided herein are compositions comprising a Clostridium botulinum neurotoxin serotype A (BoNT/A) complex comprising a 150 kDa BoNT/A. Said 150 kDa BoNT/A is in the form of a plurality of sequence variant species, wherein the plurality of sequence variant species comprises a 150 kDa BoNT/A sequence variant species with a C-terminal truncated light chain.

Abstract: The present disclosure relates to Clostridium botulinum neurotoxin serotype A (BoNT/A) compositions with a plurality of 900 kDa Clostridium botulinum neurotoxin serotype A (BoNT/A) complex species. Provided herein are compositions comprising BoNT/A that have a low level of oxidation at specific methionine positions of 150 kDa BoNT/A. Further provided herein are methods of producing a composition comprising BoNT/A using a low temperature during the process of fermenting Clostridium botulinum bacteria.

Abstract: The present disclosure relates to a resource allocation method, a resource allocation apparatus and a storage medium. The method comprises: constructing a comprehensive data system from medical insurance data and clinical path data, and determining effect parameters of different diseases accordingly; determining marginal effect parameters of a plurality of diseases according to the medical insurance data and the effect parameters of the plurality of diseases; determining resource allocation increments of the plurality of diseases in the whole disease spectrum according to the marginal effect parameters and increase amount of medical insurance resources.

Abstract: An electrical switching cluster system includes a plurality of input nodes, a plurality of intermediate nodes, and a plurality of output nodes. Each of the input nodes performs electrical switching on electrical signals to obtain a plurality of groups of first electrical signals, and converts one group of first electrical signals into a multi-wavelength first optical signal. Each of the intermediate nodes demultiplexes a plurality of first optical signals to obtain a plurality of groups of second optical signals, and multiplexes optical signals of different wavelengths in the plurality of groups of second optical signals to obtain a plurality of multi-wavelength third optical signals. Each of the output nodes converts one third optical signal into one group of second electrical signals, and performs electrical switching on a plurality of groups of second electrical signals to output the plurality of groups of second electrical signals through any output port.

Abstract: Methods and apparatus for a reconfigurable optical add-drop multiplexer (ROADM) cluster node are provided. In some embodiments, the ROADM cluster node includes a set of g line chassis for performing line functionality. In some embodiments, the ROADM cluster node further includes a set of h add-drop chassis for performing add-drop functionality. In some embodiments, each of the g line chassis includes a set of N line cards and a set of M interconnect cards. In some embodiments, the ROADM cluster node further includes a set of M interconnect chassis configured for interconnecting each line chassis to each other line chassis. In some embodiments, the set of M interconnect chassis is further configured for interconnecting each line chassis to each of the h add-drop chassis. In some embodiments, the ROADM cluster node separates the line functionality and add-drop functionality. In some embodiments, 1.15N?M?1.5N.

Abstract: A method of wavelength selection and a communication apparatus is applied to fields such as optical communication, optical switching, digital central networks, microwave photonics, liquid crystal antennas, optical phased arrays, beam forming, beam scanning, laser radars, laser projection, laser televisions, holographic display, adaptive optics, laser beam shaping, laser processing, ultrafast laser pulse shaping, laser active imaging, optical tomography scanning, and retinal imaging. When port switching occurs in a WSS apparatus, only image data of a changed local image of an LCoS image is updated within each time interval that is shorter than duration of one image frame, and a driving voltage for a pixel on the LCoS display screen is refreshed based on a priority.

Abstract: A spatial light modulator is provided, including a backplane inside which a drive circuit is disposed, a phase adjustment unit, an electrode, and an electrical connection portion. The phase adjustment unit includes a lower cavity mirror, a cavity layer, and an upper cavity mirror, and the lower cavity mirror is located between the cavity layer and the backplane. The electrode includes a first electrode and a second electrode, and the electrode is located inside or on a surface of the phase adjustment unit, and is located on a side that is of the lower cavity mirror and that faces away from the backplane. The electrical connection portion is electrically connected to the electrode and the drive circuit, to form a drive electric field between the first electrode and the second electrode, and adjust a refractive index of the phase adjustment unit.

Abstract: An optical selective switch includes N input ports, M output ports, an input passive deflection element, an input active deflection element, an output passive deflection element, and an output active deflection element. Each input port is configured to receive input light. Each output port is configured to output to-be-output light from the output port. The input passive deflection element is configured to deflect the input light to a direction corresponding to an intermediate output port. The input active deflection element is configured to deflect the input light to a direction corresponding to a target output port based on the deflection of the input passive deflection element. The output passive deflection element is configured to deflect the to-be-output light to the direction corresponding to the intermediate output port. The output active deflection element is configured to deflect the to-be-output light to the target output port.

Abstract: An under counter safe for securing items and providing quick access includes upper and lower sections forming an interior cavity, with the upper section attachable to the underside of a countertop, desk, or other surface. A linkage mechanism may connect the upper and lower sections, allowing the lower section to be raised or lowered with respect to the upper section to allow access to the interior cavity. A dual locking mechanism may secure the lower section to the upper mechanism at two points, and a release mechanism may simultaneously disengage both locking points to allow access. The release mechanism may be manually or electronically activated.

Abstract: The present disclosure provides example wavelength selective switch (WSS), wavefront control element, and integrated liquid crystal on silicon (LCoS). One example WSS includes an input port fiber array, a demultiplexing/multiplexing grating group, an output port fiber array, and a beam deflection component group including two beam deflection components and at least one wavefront control element located between the demultiplexing/multiplexing grating group and the beam deflection component group or integrated with the LCoS. At least one beam deflection component is a LCoS. The input port fiber array receives multi-wavelength optical signals. The demultiplexing/multiplexing grating group demultiplexes and outputs the multi-wavelength optical signals. The beam deflection component group deflects the multi-wavelength optical signals to the demultiplexing/multiplexing grating group. The demultiplexing/multiplexing grating group multiplexes the multi-wavelength optical signals to the output port fiber array.

Abstract: A wavelength switching apparatus includes M input components, a first optical component, a first switch array, a second switch array, a second optical component, and K output components. The M input components include at least one local input component having N input ports, and a light beam input by the local input component can be converged, under an action of the first optical component, on a row of switch units that are in the first switch array and that are corresponding to the local input component. In this way, this is equivalent to further connecting an N*1-dimensional WSS to an input end of an M*K-dimensional WSS, so that the wavelength switching apparatus can integrate a wavelength adding function based on the M*K-dimensional WSS.

Abstract: Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.

Abstract: A method for brewing a beverage, a water concentrate for brewing the beverage and the beverage thereof are provided, wherein the water concentrate includes a hardness between 10,000 ppm and 100,000 ppm, a calcium ion concentration between 300 ppm and 10,000 ppm, a magnesium ion concentration between 200 ppm and 20,000 ppm, a sodium ion concentration between 30 ppm and 1,000 ppm, a potassium ion concentration between 30 ppm and 1,000 ppm, a bicarbonate ion between 10 ppm and 300 ppm, and a pH between 6 and 9. By controlling the hardness and mineral composition of the water concentrate, the invention increases the affinity to amino acids, flavonoid compounds, polyphenolic compounds, terpenoid compounds, alkaloids, and organic acids in coffee or tea beverages, and adds the content of substances which are helpful to the human body in addition to improving the taste and flavor of the beverages.

Abstract: Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.

Abstract: Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.

Abstract: A wavelength switching apparatus includes M input components, a first optical component, a first switch array, a second switch array, a second optical component, and K output components. The M input components include at least one local input component having N input ports, and a light beam input by the local input component can be converged, under an action of the first optical component, on a row of switch units that are in the first switch array and that are corresponding to the local input component. In this way, this is equivalent to further connecting an N*1-dimensional WSS to an input end of an M*K-dimensional WSS, so that the wavelength switching apparatus can integrate a wavelength adding function based on the M*K-dimensional WSS.