Abstract: It provides methods of treating no-GCB DLBCL with (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4, 5, 6, 7-tetrahydropyrazolo-[1, 5-a] pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof. It provides methods of treating non-GCB DLBCL in a subject, comprising administering to the subject in need thereof (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4, 5, 6, 7-tetrahydropyrazolo-[1, 5-a] pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an anti-CD20 antibody.

Abstract: Systems, methods, circuits, and apparatus including computer-readable mediums for managing page buffer circuits in memory devices are provided. In one aspect, a memory device includes a memory cell array, memory cell lines connecting respective lines of memory cells, and a page buffer circuit including page buffers coupled to the memory cell lines. Each page buffer includes a sensing latch circuit and a storage latch circuit. The sensing latch circuit includes a sensing transistor coupled to a sensing node and at least one sensing latch unit having a first node coupled to the sensing node and a second node coupled to a first terminal of the sensing transistor. The storage latch circuit includes at least one storage latch unit having third and fourth nodes coupled to the sensing node and a gate terminal of the sensing transistor. A second terminal of the sensing transistor is coupled to a ground.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: This application provides a data encryption method, a data decryption method, a secure data backup method, a secure data restoration method, and an electronic device. Different types of data packets in the card data are separately encrypted by using a secure element SE and a trusted execution environment TEE. In the encryption process, a user and a third-party card data provider are introduced, and are separately responsible for generation, storage, and delivery of one of key factors. Then, a real backup key is generated with reference to a key factor provided by a mobile phone party. After being encrypted in the SE and the TEE by using the backup key, the card data is uploaded to a cloud server for backup. The application can ensures data backup security in the SE and the TEE.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: A memory unit with an asymmetric group-modulated input scheme and a current-to-voltage signal stacking scheme for a plurality of non-volatile computing-in-memory applications is configured to compute a plurality of multi-bit input signals and a plurality of weights. A controller splits the multi-bit input signals into a plurality of input sub-groups and generates a plurality of switching signals according to the input sub-groups, and the input sub-groups are sequentially inputted to the word lines. The current-to-voltage signal stacking converter converts the bit-line current from a plurality of non-volatile memory cells into a plurality of converted voltages according to the input sub-groups and the switching signals, and the current-to-voltage signal stacking converter stacks the converted voltages to form an output voltage. The output voltage is corresponding to a sum of a plurality of multiplication values which are equal to the multi-bit input signals multiplied by the weights.

Abstract: Systems, methods, circuits, and apparatus for managing flip flop circuits are provided. In one aspect, a flip flop circuit includes a first sub-circuit having a first inner node between a first input node and a first output node, a second sub-circuit having a second inner node between a second input node and a second output node, and a third sub-circuit coupled between the first and second inner nodes. The third sub-circuit is configured to be: in an open state to conductively disconnect the first and second inner nodes, and in a close state to conductively connect the first and second inner nodes, such that a first output at the first output node corresponds to a second input at the second input node and a second output at the second output node corresponds to a first input at the first input node.

Abstract: A memory unit with an asymmetric group-modulated input scheme and a current-to-voltage signal stacking scheme for a plurality of non-volatile computing-in-memory applications is configured to compute a plurality of multi-bit input signals and a plurality of weights. A controller splits the multi-bit input signals into a plurality of input sub-groups and generates a plurality of switching signals according to the input sub-groups, and the input sub-groups are sequentially inputted to the word lines. The current-to-voltage signal stacking converter converts the bit-line current from a plurality of non-volatile memory cells into a plurality of converted voltages according to the input sub-groups and the switching signals, and the current-to-voltage signal stacking converter stacks the converted voltages to form an output voltage. The output voltage is corresponding to a sum of a plurality of multiplication values which are equal to the multi-bit input signals multiplied by the weights.

Abstract: A method for analyzing gait of a user includes: detecting, by left and right motion sensors respectively mounted on left and right shoes, movement of the left and right shoes so as to generate and output left-foot motion information and right-foot motion information; and by a processing unit, performing gait analysis based on plural sets of coordinates in a Cartesian coordinate system that are contained in the left-foot motion information and the right-foot motion information so as to generate a result of the gait analysis.

Abstract: A memory unit is controlled by a word line, a reference voltage and a bit-line clamping voltage. A non-volatile memory cell is controlled by the word line and stores a weight. A clamping module is electrically connected to the non-volatile memory cell via a bit line and controlled by the reference voltage and the bit-line clamping voltage. A clamping transistor of the clamping module is controlled by the bit-line clamping voltage to adjust a bit-line current. A cell detector of the clamping module is configured to detect the bit-line current to generate a comparison output according to the reference voltage. A clamping control circuit of the clamping module switches the clamping transistor according to the comparison output and the bit-line clamping voltage. When the clamping transistor is turned on by the clamping control circuit, the bit-line current is corresponding to the bit-line clamping voltage multiplied by the weight.

Abstract: A method for analyzing gait of a user includes: detecting, by left and right motion sensors respectively mounted on left and right shoes, movement of the left and right shoes so as to generate and output left-foot motion information and right-foot motion information; and by a processing unit, performing gait analysis based on plural sets of coordinates in a Cartesian coordinate system that are contained in the left-foot motion information and the right-foot motion information so as to generate a result of the gait analysis.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: A method for obtaining a relation between a winding state and a leakage reactance parameter of a transformer by using simulation software is provided. The method includes: establishing a simulation transformer based on a size of a physical transformer; setting parameters of the simulation transformer, setting a winding of the simulation transformer in a predetermined winding state; obtaining a predetermined number of values of a leakage reactance parameter of the simulation transformer in the winding state; and performing statistics on all the values to obtain a value range of the leakage reactance parameter in a case that the winding is in the winding state. The value range is used as a value range of a leakage reactance parameter of the physical transformer in a case that a winding of the physical transformer is in the winding state.

Abstract: A data transmission method is performed by at least one processor of a terminal, and includes displaying one or more messages, each of the one or more messages including a data file, based on a touch and hold input on one of the one or more messages, displaying an option for displaying one or more icons respectively indicating one or more hardware devices capable of executing the data file of the one of the one or more messages, based on a touch input on the option, displaying the one or more icons respectively indicating the one or more hardware devices, and based on a touch input on one of the one or more icons indicating one of the one or more hardware devices, sending, to the one of the one or more hardware devices, the data file of the one of the one or more messages.

Abstract: A data transmission method is performed by at least one processor of a terminal, and includes displaying one or more messages, each of the one or more messages including a data file, based on a touch and hold input on one of the one or more messages, displaying an option for displaying one or more icons respectively indicating one or more hardware devices capable of executing the data file of the one of the one or more messages, based on a touch input on the option, displaying the one or more icons respectively indicating the one or more hardware devices, and based on a touch input on one of the one or more icons indicating one of the one or more hardware devices, sending, to the one of the one or more hardware devices, the data file of the one of the one or more messages.

Abstract: The present invention resides in the surprising discovery of the previously unrecognized synergistic effects resulted from combined use of narigenin and asiatic acid. New methods and compositions are therefore provided for the treatment or prevention of various types of cancer.

Abstract: The present invention provides for modified natural killer (NK) cells that are resistant to TGF-? stimulation due to suppressed Smad3 activity in these cells. Also provided are compositions comprising these modified NK cells, as well as methods of treating cancer by using the cells.

Abstract: A method for producing isopropyl benzene includes the following steps. Step A: feeding a first stream containing benzene and a first stream containing propylene into a first reaction zone to contact a first catalyst for alkylation, and obtaining a first stream containing isopropyl benzene from the first reaction zone, dividing the first stream containing isopropyl benzene into a stream Ia and a stream IIa, the stream Ia circulating back into the first reaction zone and the stream IIa entering into a second reaction zone, having the stream entering the second reaction zone to contact a second catalyst for alkylation, and obtaining a second stream containing isopropyl benzene from the second reaction zone, and purifying at least a partial stream IIIa of the second stream containing isopropyl benzene, and obtaining a product isopropyl benzene.

Abstract: The present invention discloses a method for heat treatment of hypereutectoid steel rail, including the following steps: holding the temperature of the steel rail of which temperature is above 900° C. after finish rolling, conducting a first cooling stage for the steel rail at the first cooling speed after the temperature holding to reduce the temperature of railhead surface layer of the steel rail to 700-750° C., conducting a second cooling stage for the steel rail at the second cooling speed to reduce the temperature of railhead surface layer of the steel rail to 550° C., conducting a third cooling stage for the steel rail at the third cooling speed to reduce the temperature of railhead surface layer of the steel rail to 450° C. or less, and continuing to cool the steel rail in the air.

Abstract: A catalyst for catalytic cracking in a fluidized-bed is disclosed. The catalyst comprises a support and a composition having the chemical formula (on the basis of the atom ratio): AaBbPcOx for use in the industrial production of ethylene and propylene by catalytically cracking naphtha.