Patents by Inventor Hui-Yin Li

Hui-Yin Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
    Publication number: 20080312259
    Abstract: The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
    Type: Application
    Filed: June 12, 2008
    Publication date: December 18, 2008
    Applicant: INCYTE CORPORATION
    Inventors: James D. Rodgers, Hui-Yin Li
  • POLYMORPHIC FORMS OF 6-11 BICYCLIC KETOLIDE DERIVATIVES
    Publication number: 20080248105
    Abstract: The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 9, 2008
    Inventors: Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Sun Or, Hui-Yin Li
  • Polymorphic forms of 6-11 bicyclic ketolide derivatives
    Patent number: 7384921
    Abstract: The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: June 10, 2008
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Sun Or, Hui-Yin Li
  • SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES
    Publication number: 20070027186
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: September 7, 2006
    Publication date: February 1, 2007
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7153960
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Salts of N-[2-({(3R)-1-[trans-4-hydroxy-4-(6-methoxypyridin-3-yl)-cyclohexyl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide
    Publication number: 20060111404
    Abstract: The present invention pertains to bis(methanesulfonic acid), bis(ethanesulfonic acid), and camphoric acid salts of chemokine receptor inhibitor N-[2-({(3R)-1-[trans-4-hydroxy-4-(6-methoxypyridin-3-yl)-cyclohexyl]-pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)-benzamide, methods of preparing the same, and methods of using the same.
    Type: Application
    Filed: November 21, 2005
    Publication date: May 25, 2006
    Inventors: Chu-Biao Xue, Brian Metcalf, Hui-Yin Li, Hao Feng, Joseph Glenn
  • Novel stable compositions of water and oxygen sensitive compounds and their method of preparation
    Publication number: 20050288257
    Abstract: The present application described a new formulation for oxygen and/or water sensitive compounds with an inert material such as paraffin. The new formulation provides stability for the oxygen and/or water sensitive compounds in the air and can be handled easily. The new formulation of the present invention is useful as ligands and/or catalysts for preparation of pharmaceuticals, agrochemical, other fine chemicals and other synthetic compounds.
    Type: Application
    Filed: June 23, 2005
    Publication date: December 29, 2005
    Inventors: Douglass Taber, Hui-Yin Li
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Publication number: 20050245566
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: June 8, 2005
    Publication date: November 3, 2005
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Polymorphic forms of 6-11 bicyclic ketolide derivatives
    Publication number: 20050203035
    Abstract: The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
    Type: Application
    Filed: February 14, 2005
    Publication date: September 15, 2005
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Or, Hui-Yin Li
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Patent number: 6919451
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: July 19, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Efficient process for the preparation of a factor Xa inhibitor
    Publication number: 20040198787
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1
    Type: Application
    Filed: April 15, 2004
    Publication date: October 7, 2004
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Patent number: 6747158
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: June 8, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Patent number: 6667332
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: December 23, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Christopher A. Teleha, Jia C. Zhou, Thomas E. Smyser
  • Efficient process for the preparation of a factor Xa inhibitor
    Publication number: 20030212117
    Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1
    Type: Application
    Filed: May 7, 2003
    Publication date: November 13, 2003
    Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Lucius T. Rossano, Christopher A. Teleha, Jiacheng Zhou, Thomas E. Smyser
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Publication number: 20030181466
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described.
    Type: Application
    Filed: December 3, 2002
    Publication date: September 25, 2003
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Efficient method for the conversion of nitriles to amidines
    Patent number: 6610858
    Abstract: The present invention relates to processes for the conversion of nitriles to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: August 26, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Efficient ligand-mediated Ullmann coupling of anilines and azoles
    Patent number: 6541639
    Abstract: The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: April 1, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Pasquale N. Confalone, Hui-Yin Li, Philip Ma, Lynette M. Oh, Lucius T. Rossano, Charles G. Clark, Chris Teleha
  • Efficient method for the conversion of nitriles to amidines
    Publication number: 20020165400
    Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.
    Type: Application
    Filed: April 25, 2002
    Publication date: November 7, 2002
    Inventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
  • Synthesis of 1,3,5-trisubstituted pyrazoles
    Patent number: 6465656
    Abstract: A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: October 15, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Pasquale N. Confalone, Hui-Yin Li, Philip Ma
  • Efficient ligand-mediated ullmann coupling of anilnies and azoles
    Publication number: 20020099225
    Abstract: The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
    Type: Application
    Filed: July 25, 2001
    Publication date: July 25, 2002
    Inventors: Jiacheng Zhou, Pasquale N. Confalone, Hui-Yin Li, Philip Ma, Lynette M. Oh, Lucius T. Rossano, Charles G. Clark, Chris Teleha