Abstract: A fiber-metal laminate having a honeycomb sandwich structure and a preparation method thereof are provided. Firstly, based on material reduction processing technology, a recessed polygonal structure is obtained according to a design trajectory, and an upper layer and a lower layer are closed to form a recessed honeycomb sandwich structure. Then, processed surfaces of the upper layer and the lower layer are chemically treated to passivate the processed surfaces, with the aim of increasing the adhesion between a fiber layer and the metal layers. Then, a viscous mixture is filled into the recessed structures of the metal layers to ensure the multifunctional characteristics and impact resistance of the fiber-metal laminate. Then, a fiber prepreg is laid between the upper layer and the lower layer to obtain a prefabricated fiber-metal laminate. Finally, the prefabricated fiber-metal laminate undergoes thermal curing treatment under pressure in a hot-pressing tank, thereby obtaining the fiber-metal laminate.

Abstract: The invention relates to a method of selecting a subject for treatment with a combination of an AXL inhibitor (AXLi) and an immune checkpoint modulator (ICM), the method comprising: identifying subjects having an AXL-related disease characterised by the presence of cells having modified STK11 activity or expression; and, selecting thus identified subjects for treatment. The invention also relates to an AXL inhibitor (AXLi) and an immune checkpoint modulator (ICM) for use in the treatment of an AXL-related disease.

Abstract: The present invention relates to a method for preparing 2,6-dichloropyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between pyridine and chlorine gas. The preparation process comprises the following steps: enabling pyridine and chlorine gas to continuously experience chlorination reaction under irradiation of ultraviolet light by using pyridine and chlorine gas as starting materials and using trifluoromethyl chlorobenzene as a solvent, and cooling a chlorination reaction product and the solvent to obtain pyridine chlorination solution. Advantages: firstly, it pioneers the precedent of direct and high-selectivity preparation of 2,6-dichloropyridine through liquid phase photochlorination, and not only can the 2,6-dichloropyridine product with purity greater than or equal to 99.

Abstract: Disclosed are markers for nasopharyngeal carcinoma (NPC) diagnosis and prognostic prediction, and use thereof. The INSL5 level in a plasma sample can be determined by means of ELISA. It was found that the INSL5 plasma level is significantly different between NPC patients and healthy population. The analysis results of a ROC curve show that an area under curve of INSL5 is 0.941, the critical value of the INSL5 level is 2.45 ng/ml, and the sensitivity and specificity thereof are 93.2% and 81.5% respectively. In the healthy cohort, the INSL5 level in EBV-positive plasma is significantly higher than that in EBV-negative plasma. The EBV-negative subjects comprise 34 healthy individuals and 72 NPC patients, and the INSL5 levels are observed to be significantly different between these two cohorts. The results of the ROC curve show that the area under curve of INSL5 is 0.988, the critical value of the INSL5 level is 2.25 ng/ml, and the sensitivity and specificity thereof are 97.2% and 91.2% respectively.

Abstract: The present invention relates to a method for preparing 2-chloro-6-trichloromethylpyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between 2-methylpyridine with chlorine gas, in which 2-methylpyridine and chlorine gas are used as starting materials, trifluoromethyl chlorobenzene is used as a solvent, 2-methylpyridine is prepared into a liquid raw material by using the solvent trifluoromethyl chlorobenzene, and the liquid raw material is continuously fed to perform liquid phase photochlorination reaction at temperature of 160-240° C. under irradiation of ultraviolet light to obtain 2-chloro-6-trichloromethylpyridine solution.

Abstract: The present invention relates to a method for preparing 2,6-dichloropyridine with product purity greater than or equal to 99.0% through gas phase photochlorination of pyridine by using trifluoromethyl chlorobenzene as a solvent for reaction between pyridine and chlorine gas. Gasified pyridine and heated chlorine gas are enabled to continuously experience chlorination reaction under irradiation of ultraviolet light by using gasified pyridine and heated chlorine gas as starting materials and using heated trifluoromethyl chlorobenzene as a solvent, and a gas phase reaction product and the solvent are cooled to obtain pyridine chlorination solution. Advantages: firstly, it pioneers the precedent of direct and high-selectivity preparation of 2,6-dichloropyridine through gas phase photochlorination, and not only can the 2,6-dichloropyridine product with purity greater than or equal to 99.

Abstract: A loudspeaker module comprises a loudspeaker unit and a module housing. A front acoustic cavity and a rear acoustic cavity are formed between the module housing and the loudspeaker unit. The upper and lower ends of the front acoustic cavity and the rear acoustic cavity are open. The upper and lower end surfaces of the module housing are combined with a terminal electronic device through sealing cushions. An electronic device is also disclosed. The upper and lower surfaces of the module housing are combined with the circuit board or the device housing through sealing cushions. Such a structure fully utilizes the spaces of the loudspeaker module and the electronic device, expands the internal space of the loudspeaker module, increases the sizes of the loudspeaker unit and the sound cavities, and accordingly improves the acoustical performance of the product.

Abstract: A loudspeaker module comprises a loudspeaker unit and a module housing. A front acoustic cavity and a rear acoustic cavity are formed between the module housing and the loudspeaker unit. The upper and lower ends of the front acoustic cavity and the rear acoustic cavity are open. The upper and lower end surfaces of the module housing are combined with a terminal electronic device through sealing cushions. An electronic device is also disclosed. The upper and lower surfaces of the module housing are combined with the circuit board or the device housing through sealing cushions. Such a structure fully utilizes the spaces of the loudspeaker module and the electronic device, expands the internal space of the loudspeaker module, increases the sizes of the loudspeaker unit and the sound cavities, and accordingly improves the acoustical performance of the product.

Abstract: This invention is involved with a preparation method of 2,6-dichloro-4-trifluoromethyl-aniline. With this process, p-Chlorobenzotrifluoride is used as the starting material and subjected to halogenation reaction and ammoniation reaction and through separation of reaction products the desired 2,6-dichloro-4-trifluoromethyl-aniline is obtained. In addition, ammonia is recovered from the surplus ammonia water in ammoniation reaction. This applied invention in characterized by simple process, cheap and easy-available raw materials, high reaction yield and friendly environment.

Abstract: This invention is involved with a preparation method of 2,6-dichlor-4-trifluoromethyl aniline. With this process, 4-chlorotrifluoromethyl benzene is used as the starting material and subjected to halogenation reaction and ammoniation reaction and through separation of reaction products the desired 2,6-dichlor-4-trifluoromethyl aniline is obtained. In addition, ammonia is recovered from the surplus ammonia water in ammoniation reaction. This applied invention in characterized by simple process, cheap and easy-available raw materials, high reaction yield and friendly environment.