Abstract: The present invention provides a detection reagent and therapeutic target for B cell tumor after targeted therapy and related applications. The reagent composition comprises 3 groups of antibodies, with the first group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD24 an antibody, an anti-CD20 antibody, an anti-CD81 antibody, an anti-CD45 antibody; the second group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD20 antibody, an anti-CD72 antibody, an anti-CD45 antibody; and the third group of antibodies including an anti-cytoplasmic CD79a antibody. The reagent composition of the present invention can be applied for the detection of B-lymphocyte tumors after targeted therapy by flow cytometry.

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Abstract: Flow cell devices, cartridges, and systems are described that provide reduced manufacturing complexity, lowered consumable costs, and flexible system throughput for nucleic acid sequencing and other chemical or biological analysis applications. The flow cell device can include a capillary flow cell device or a microfluidic flow cell device.

Abstract: A server with a cooling system which can maintain a constant and preferred operating temperature for the server includes a computer and a heat dissipation device for dissipating heat generated by the computer. The heat dissipation device includes a liquid tank and a heat exchange device. The liquid tank defines an accommodating cavity for accommodating non-conductive cooling liquid and the computer. The heat exchange device is connected to the liquid tank to exchange heat with the non-conductive cooling liquid in the liquid tank.

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Abstract: A server includes a case, a mounting frame, a heating element, a connecting plate, and a cooling mechanism. The heating element, the connecting plate, and the cooling mechanism are mounted on the mounting frame. The heating element is detachably mounted on the connecting plate. The cooling mechanism is coupled to the heating element. The mounting frame is detachably mounted in the case. The connecting plate includes a plug portion configured to plug with an operating mechanism mounted in the case.

Abstract: A server includes a case, a mounting frame, a heating element, a connecting plate, and a cooling mechanism. The heating element, the connecting plate, and the cooling mechanism are mounted on the mounting frame. The heating element is detachably mounted on the connecting plate. The cooling mechanism is coupled to the heating element. The mounting frame is detachably mounted in the case. The connecting plate includes a plug portion configured to plug with an operating mechanism mounted in the case.

Abstract: Provided are methods and systems for analyzing nucleic acids in a biological sample in a manner that retains the spatial and/or cellular origin of the nucleic acids within the biological sample. Compositions and kits are also provided that enable the methods and systems of the instant disclosure.

Abstract: A hard disk fixing mechanism implemented in a chasses includes a fixing frame, at least one mounting frame, and at least one fixing mechanism. The fixing frame includes a base plate and a first fixing plate arranged on the base plate. The first fixing plate defines at least one through slot. The base plate bears the mounting frame. The mounting frame mounts a hard disk. The mounting frame includes a projecting portion. The projecting portion defines a through hole. The projecting portion extends from the through slot to an opposite side of the first fixing plate. The fixing mechanism includes a sliding block. The sliding block is movably arranged on the first fixing plate and extends into the through hole to lock the mounting frame.

Abstract: A supporting base for servers of different types and sizes includes two sliding rails and a mounting apparatus. The supporting base includes sliding portions on each side and supporting brackets corresponding to the two sliding portions. When the two supporting brackets are unmounted, the supporting base and sliding rails have a first distance, and when the two supporting brackets are mounted to the two sliding portions, the two sliding rails have a second distance.

Abstract: A method of fatigue life prediction including: calculating a critical crack size of an object of interest; identifying a first flaw in ultrasound data of the object of interest; determining that the first flaw interacts with a second flaw, the first flaw is to be merged with the second flaw, or the first flaw is isolated; calculating an initial crack size based on the determination; and calculating an increase in the initial crack size due to fatigue and creep to determine a number of load cycles until the initial crack size reaches the critical crack size.

Abstract: A method of fatigue life prediction including: calculating a critical crack size of an object of interest; identifying a first flaw in ultrasound data of the object of interest; determining that the first flaw interacts with a second flaw, the first flaw is to be merged with the second flaw, or the first flaw is isolated; calculating an initial crack size based on the determination; and calculating an increase in the initial crack size due to fatigue and creep to determine a number of load cycles until the initial crack size reaches the critical crack size.

Abstract: A trace-detecting computer input device such as a touch input device, optical tracing module, or optical tracing plate includes a trace-detecting module and a microswitch. The trace-detecting module has a neutral position and a depressed position. A first control signal is generated when an object moves across the top of the trace-detecting module. When the trace-detecting module is in the depressed position, the microswitch is activated to generate a second control signal which is in addition to the trace-detecting first control signal.

Abstract: The present invention relates to a wired input device with an adjustable cable arrangement. The wired input device may include, but is not limited to, a computer mouse, track ball, or game controller. To enable adjustment of cable position, the wired input device includes an adjustment mechanism that permits the position and direction at which the cable exits the device to be changed.

Abstract: A trace-detecting computer input device such as a touch input device, optical tracing module, or optical tracing plate includes a trace-detecting module and a microswitch. The trace-detecting module has a neutral position and a depressed position. A first control signal is generated when an object moves across the top of the trace-detecting module. When the trace-detecting module is in the depressed position, the microswitch is activated to generate a second control signal which is in addition to the trace-detecting first control signal.

Abstract: The present invention relates to a wired input device with an adjustable cable arrangement. The wired input device may include, but is not limited to, a computer mouse, track ball, or game controller. To enable adjustment of cable position, the wired input device includes an adjustment mechanism that permits the position and direction at which the cable exits the device to be changed.

Abstract: A system for querying reports using a mobile computing device includes a database server (107), an application server (103) to access and handle information stored in the database server, and mobile terminals (101) each connected with the application server by communication channels (115, 113). Each mobile terminal includes an information searching module (305), a link-switching module (303), a data synchronization module (309), a data filter module (307), and a data storage (310). The information searching module further includes a vehicle orders daily searching sub-module (3050), and a distributor orders daily searching sub-module (3052). The link-switching module is for switching states of connection as between the mobile terminal and the application server. The data synchronization module is for downloading information for synchronization from the application server.