Abstract: Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.

Abstract: Provided are a vehicle body and a vehicle. The vehicle body includes: two A pillars; a front impact beam; two front longitudinal beams having front ends connected to the front impact beam, and each of the front longitudinal beams being connected to the A-pillar at the same side therewith by means of a plurality of force transmission paths; a dash panel having lower portion provided with a dash centre aisle and connected to the two A-pillars; an dash upper cross member provided at an upper portion of the dash panel; a dash lower vertical member having an upper end connected to the dash upper cross member and a lower end extending to the dash centre aisle; and two front floor longitudinal beams.

Abstract: Provided are a vehicle body and a vehicle. The vehicle body includes: a front longitudinal beam; a first bracket; an upper side beam having a front lower end connected to an outer end of the first bracket; a front floor longitudinal beam having a front end connected to a rear end of the front longitudinal beam and having a linear configuration; a rocker panel having a front end connected to the rear end of the front longitudinal beam; and a rear floor longitudinal beam connected to a rear end of the front floor longitudinal beam and a rear end of the rocker panel to make the front floor longitudinal beam, the rocker panel, and the rear floor longitudinal beam form a closed-loop force transmission structure.

Abstract: Provided are a vehicle body and a vehicle. The vehicle body includes: a front longitudinal beam; a first bracket; an upper side beam having a front lower end connected to an outer end of the first bracket; a front floor longitudinal beam having a front end connected to a rear end of the front longitudinal beam and having a linear configuration; a rocker panel having a front end connected to the rear end of the front longitudinal beam; and a rear floor longitudinal beam connected to a rear end of the front floor longitudinal beam and a rear end of the rocker panel to make the front floor longitudinal beam, the rocker panel, and the rear floor longitudinal beam form a closed-loop force transmission structure.

Abstract: Provided are a vehicle body and a vehicle. The vehicle body includes: two A pillars; a front impact beam; two front longitudinal beams having front ends connected to the front impact beam, and each of the front longitudinal beams being connected to the A-pillar at the same side therewith by means of a plurality of force transmission paths; a dash panel having lower portion provided with a dash centre aisle and connected to the two A-pillars; an dash upper cross member provided at an upper portion of the dash panel; a dash lower vertical member having an upper end connected to the dash upper cross member and a lower end extending to the dash centre aisle; and two front floor longitudinal beams.

Abstract: The present invention provides a thermally curable pressure-sensitive adhesive composition, which, based on the total weight of the composition, comprises the following components: a) 35-99% by weight of a reactive polymethacrylate component having a glass transition temperature Tg of ?35° C. to 32° C., and having a reactive functional group which can react with benzoxazine to form an interpenetrating polymer network; and b) 1-65% by weight of a benzoxazine component of the following formula: wherein: X is selected from the group consisting of a covalent bond, C1-C6 alkylene, C3-C10 cycloalkylene group, C?O, S, S?O or O?S?O R1 and R2 are the same or different and independently of each other selected from the group consisting of hydrogen, C1-C6 alkyl, or C5-C14 aryl, and R4 is selected from the group consisting of hydrogen, halogen or C1-C6 alkyl.

Abstract: The present invention provides a thermally curable pressure-sensitive adhesive composition, which, based on the total weight of the composition, comprises the following components: a) 35-99% by weight of a reactive polymethacrylate component having a glass transition temperature Tg of ?35° C. to 32° C., and having a reactive functional group which can react with benzoxazine to form an interpenetrating polymer network; and b) 1-65% by weight of a benzoxazine component of the following formula: wherein: X is selected from the group consisting of a covalent bond, C1-C6 alkylene, C3-C10 cycloalkylene group, C?O, S, S?O or O?S?O R1 and R2 are the same or different and independently of each other selected from the group consisting of hydrogen, C1-C6 alkyl, or C5-C14 aryl, and R4 is selected from the group consisting of hydrogen, halogen or C1-C6 alkyl.

Abstract: The present disclosure provides a method of making a mammal (e.g., a rodent, such as a mouse) by integrating an intact polynucleotide sequence into a specific genomic locus of the mammal to result in a transgenic mammal. A transgenic mammal made by the methods of the present disclosure would contain a known copy number (e.g., one) of the inserted polynucleotide sequence at a predetermined location. The method involves introducing a site-specific recombinase and a targeting construct, containing a first recombination site and the polynucleotide sequence of interest, into the mammalian cell. The genome of the cell contains a second recombination site and recombination between the first and second recombination sites is facilitated by the site-specific, uni-directional recombinase. The result of the recombination is site-specific integration of the polynucleotide sequence of interest in the genome of the mammal. This inserted sequence is then also transmitted to the progeny of the mammal.

Abstract: A scanner for an electronic device having image display functionality includes lower and upper housings, a scan unit, and an adaptor. The lower housing is formed on opposite sides with a paper inlet and a paper outlet. The upper housing is mounted on the lower housing, and includes a main body provided with a terminal hole, and a support member disposed proximate to the terminal hole and to abut against the electronic device when the electronic device is connected to the scanner. The scan unit includes a scan module disposed between the lower and upper housings, a control module coupled to the scan module, and a connecting terminal coupled to the control module and accessible via the terminal hole. The adaptor is removably mounted to the connecting terminal so as to permit direct electrical connection between the scanner and the electronic device.

Abstract: A scanner for an electronic device having image display functionality includes lower and upper housings, a scan unit, and an adaptor. The lower housing is formed on opposite sides with a paper inlet and a paper outlet. The upper housing is mounted on the lower housing, and includes a main body provided with a terminal hole, and a support member disposed proximate to the terminal hole and to abut against the electronic device when the electronic device is connected to the scanner. The scan unit includes a scan module disposed between the lower and upper housings, a control module coupled to the scan module, and a connecting terminal coupled to the control module and accessible via the terminal hole. The adaptor is removably mounted to the connecting terminal so as to permit direct electrical connection between the scanner and the electronic device.

Abstract: The present disclosure provides a method of making a mammal (e.g., a rodent, such as a mouse) by integrating an intact polynucleotide sequence into a specific genomic locus of the mammal to result in a transgenic mammal. A transgenic mammal made by the methods of the present disclosure would contain a known copy number (e.g., one) of the inserted polynucleotide sequence at a predetermined location. The method involves introducing a site-specific recombinase and a targeting construct, containing a first recombination site and the polynucleotide sequence of interest, into the mammalian cell. The genome of the cell contains a second recombination site and recombination between the first and second recombination sites is facilitated by the site-specific, uni-directional recombinase. The result of the recombination is site-specific integration of the polynucleotide sequence of interest in the genome of the mammal. This inserted sequence is then also transmitted to the progeny of the mammal.

Abstract: Disclosed herein are transgenic mouse tumor models. A portion of the cells of the disclosed transgenic mice undergo directed somatic recombination and the mouse is therefore a mosaic for homozygous knockout of p53, NF1, or both p53 and NF1 genes. The homozygous null cells resulting from the somatic recombination also express a detectable fluorescent protein, and the resulting sibling cells, which are wild type for p53, NF1, or both p53 and NF1, express a different detectable fluorescent protein. Also disclosed herein are methods of identifying compounds for treating or preventing a tumor, using the disclosed transgenic mice.

Abstract: Recombination in mammalian somatic cell chromosomes is promoted and marked by a method called mosaic analysis with double marker (MADM). Mouse “knock-in” techniques are used to create pairs of chromosomes in which recombinase target sites are placed at homologous chromosomal locations. The knock-in constructs are engineered so that cellular markers, such as green or red fluorescent protein (GFP or RFP), are only expressed after recombinase-induced recombination. This system provides high-sensitivity detection of recombinase-induced mitotic recombination, even down to the single cell level. When this recombination is induced in a mouse heterozygous for a mutation in a gene distal to the “knock-in” locus on the same chromosome, it results in homozygosity of this mutation in the labeled cells. This allows the analysis in singly-labeled neurons of genes whose pleiotropic effects might otherwise result in early lethality.

Abstract: Recombination in mammalian somatic cell chromosomes is promoted and marked by a method called mosaic analysis with double marker (MADM). Mouse “knock-in” techniques are used to create pairs of chromosomes in which recombinase target sites are placed at homologous chromosomal locations. The knock-in constructs are engineered so that cellular markers, such as green or red fluorescent protein (GFP or RFP), are only expressed after recombinase-induced recombination. This system provides high-sensitivity detection of recombinase-induced mitotic recombination, even down to the single cell level. When this recombination is induced in a mouse heterozygous for a mutation in a gene distal to the “knock-in” locus on the same chromosome, it results in homozygosity of this mutation in the labeled cells. This allows the analysis in singly-labeled neurons of genes whose pleiotropic effects might otherwise result in early lethality.