Patents by Inventor Huichen GUO

Huichen GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING FOOT-AND-MOUTH DISEASE VIRUS-LIKE PARTICLES, AND TEST STRIP FOR DETECTING FOOT-AND-MOUTH DISEASE
    Publication number: 20210016272
    Abstract: A test strip for detecting a serotype O foot-and-mouth disease, the test strip including: a bottom board; a detection layer being disposed on the bottom board and including a detection line and a control line; an absorbent layer being disposed at one end of the detection layer close to the control line; a gold colloidal conjugate pad being disposed at the other side of the detection layer close to the detection line; and a sample pad is disposed on a top of the gold colloidal conjugate pad. The gold colloidal conjugate pad is coated with colloidal gold particles that are conjugated with a Staphylococcus protein A (SPA) marker. The detection line is coated or impregnated with serotype O FMDV-like particles, and the control line is coated or impregnated with rabbit IgG.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 21, 2021
    Inventors: Shiqi SUN, Huichen GUO, Yun ZHANG, Yanyan CHANG, Yanquan WEI, Jiaxi RU, Xiaoying ZHI, Ping DU, Xiangtao LIU, Hong YIN, Jianxun LUO
  • Method for preparing foot-and-mouth disease virus-like particles
    Patent number: 10829741
    Abstract: A method for preparing serotype O foot-and-mouth disease virus-like particles, the method including: construction of small ubiquitin-like modifier fusion expression vector, construction of recombinant expression vectors, construction of recombinant co-expression vector, expression and purification of proteins, and in-vitro assembly of serotype O foot-and-mouth disease virus-like particles. The disclosure also provides a test strip for detecting serotype O foot-and-mouth disease including a bottom board, and a detection layer disposed on the top of the bottom board. A detection line and a control line are disposed on the detection layer. An absorbent layer is disposed at one end of the detection layer close to the control line, and an immuno-gold pad is disposed at the other side of the detection layer close to the detection line. A sample pad is disposed on the top of the immuno-gold pad.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 10, 2020
    Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Shiqi Sun, Huichen Guo, Yun Zhang, Yanyan Chang, Yanquan Wei, Jiaxi Ru, Xiaoying Zhi, Ping Du, Xiangtao Liu, Hong Yin, Jianxun Luo
  • Virus-like particle of Senecavirus A
    Patent number: 10532077
    Abstract: A virus-like particle of Senecavirus A, the particle including a structural protein VP0, a structural protein VP1 and a structural protein VP3. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO: 1. The structural protein VP1 is encoded by a gene sequence represented by SEQ ID NO: 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO: 3.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 14, 2020
    Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Huichen Guo, Shiqi Sun, Shichong Han, Hu Dong, Xiaoran Guo, Hong Yin, Jianxun Luo
  • Mineralized foot-and-mouth disease virus like particles, and preparation method and use thereof
    Patent number: 10532092
    Abstract: Foot-and-mouth disease virus like particles, the particles including a structural protein VP0, a structural protein VP1 including a mineralization peptide, a structural protein VP3, and a calcium phosphate coat. The structural protein VP1 including a mineralization peptide is encoded by a gene sequence represented by SEQ ID NO. 7, SEQ ID NO. 8 or SEQ ID NO. 9. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO. 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO. 3. The calcium phosphate coat covers the structural protein VP0, the structural protein VP1 including a mineralization peptide, and the structural protein VP3.
    Type: Grant
    Filed: July 4, 2018
    Date of Patent: January 14, 2020
    Assignees: LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES, ZHEJIANG UNIVERSITY
    Inventors: Huichen Guo, Shiqi Sun, Ping Du, Zhidong Teng, Ruikang Tang, Ruibo Zhao, Jiaxi Ru, Yanquan Wei, Yun Zhang, Yuan Gao, Junwu Ma, Xiangtao Liu, Hong Yin
  • METHOD FOR PREPARING FOOT-AND-MOUTH DISEASE VIRUS-LIKE PARTICLES, AND TEST STRIP FOR DETECTING FOOT-AND-MOUTH DISEASE
    Publication number: 20190367885
    Abstract: A method for preparing serotype O foot-and-mouth disease virus-like particles, the method including: construction of small ubiquitin-like modifier fusion expression vector, construction of recombinant expression vectors, construction of recombinant co-expression vector, expression and purification of proteins, and in-vitro assembly of serotype O foot-and-mouth disease virus-like particles. The disclosure also provides a test strip for detecting serotype O foot-and-mouth disease including a bottom board, and a detection layer disposed on the top of the bottom board. A detection line and a control line are disposed on the detection layer. An absorbent layer is disposed at one end of the detection layer close to the control line, and an immuno-gold pad is disposed at the other side of the detection layer close to the detection line. A sample pad is disposed on the top of the immuno-gold pad.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 5, 2019
    Inventors: Shiqi SUN, Huichen GUO, Yun ZHANG, Yanyan CHANG, Yanquan WEI, Jiaxi RU, Xiaoying ZHI, Ping DU, Xiangtao LIU, Hong YIN, Jianxun LUO
  • VIRUS-LIKE PARTICLE OF SENECAVIRUS A
    Publication number: 20190350990
    Abstract: A virus-like particle of Senecavirus A, the particle including a structural protein VP0, a structural protein VP1 and a structural protein VP3. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO: 1. The structural protein VP1 is encoded by a gene sequence represented by SEQ ID NO: 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO: 3.
    Type: Application
    Filed: May 15, 2019
    Publication date: November 21, 2019
    Inventors: Huichen GUO, Shiqi SUN, Shichong HAN, Hu DONG, Xiaoran GUO, Hong YIN, Jianxun LUO
  • MINERALIZED FOOT-AND-MOUTH DISEASE VIRUS LIKE PARTICLES, AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20190008944
    Abstract: Foot-and-mouth disease virus like particles, the particles including a structural protein VP0, a structural protein VP1 including a mineralization peptide, a structural protein VP3, and a calcium phosphate coat. The structural protein VP1 including a mineralization peptide is encoded by a gene sequence represented by SEQ ID NO. 7, SEQ ID NO. 8 or SEQ ID NO. 9. The structural protein VP0 is encoded by a gene sequence represented by SEQ ID NO. 2. The structural protein VP3 is encoded by a gene sequence represented by SEQ ID NO. 3. The calcium phosphate coat covers the structural protein VP0, the structural protein VP1 including a mineralization peptide, and the structural protein VP3.
    Type: Application
    Filed: July 4, 2018
    Publication date: January 10, 2019
    Inventors: Huichen GUO, Shiqi SUN, Ping DU, Zhidong TENG, Ruikang TANG, Ruibo ZHAO, Jiaxi RU, Yanquan WEI, Yun ZHANG, Yuan GAO, Junwu MA, Xiangtao LIU, Hong YIN