Abstract: The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy.

Abstract: Disclosed is a method for treating ophthalmic inflammatory conditions in a subject by providing immune checkpoints inhibitors to the subject. Further disclosed are combinations of immune checkpoint inhibitors comprising enhanced therapeutic efficiency.

Abstract: The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

Abstract: Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.

Abstract: A method of operating a social networking application via an external device includes at an external device having one or more processors and memory storing programs executed by the one or more processors, receiving one or more new message notifications of a social networking application from a social networking terminal; acquiring a playback instruction from a user to play a new message of the social networking application on the external device; transmitting the playback instruction to the social networking terminal; receiving a first voice message corresponding to the new message of the social networking application from the social networking terminal; and playing the first voice message on the external device.

Abstract: The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

Abstract: A method of operating a social networking application via an external device includes at an external device having one or more processors and memory storing programs executed by the one or more processors, receiving one or more new message notifications of a social networking application from a social networking terminal; acquiring a playback instruction from a user to play a new message of the social networking application on the external device; transmitting the playback instruction to the social networking terminal; receiving a first voice message corresponding to the new message of the social networking application from the social networking terminal; and playing the first voice message on the external device.

Abstract: The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4; R2 is selected from H, F, Cl, Br or I; R3 is selected from H or C1-C4 alkyl; X is selected from S or CH2; wherein R4 is selected from C1-C10 alkyl.

Abstract: A method of operating a social networking application via an external device includes at an external device having one or more processors and memory storing programs executed by the one or more processors, receiving one or more new message notifications of a social networking application from a social networking terminal; acquiring a playback instruction from a user to play a new message of the social networking application on the external device; transmitting the playback instruction to the social networking terminal; receiving a first voice message corresponding to the new message of the social networking application from the social networking terminal; and playing the first voice message on the external device.

Abstract: Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.

Abstract: The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy.

Abstract: An input device includes an input module and a fixing module matching the input module. The input module is a sphere having a cavity, the input module includes a signal detection unit and a signal output unit, the signal detection unit and the signal output unit are placed in the cavity after being electrically connected, the signal detection unit is configured to generate a corresponding input signal according to a preset operation performed by a user on the input module, and the signal output unit is connected to an external terminal and configured to output the input signal to the terminal. The fixing module is configured to fix the input device on a preset flat surface.

Abstract: The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4; R2 is selected from H, F, Cl, Br or I; R3 is selected from H or C1-C4 alkyl; X is selected from S or CH2; wherein R4 is selected from C1-C10 alkyl.

Abstract: An input device includes an input module and a fixing module matching the input module. The input module is a sphere having a cavity, the input module includes a signal detection unit and a signal output unit, the signal detection unit and the signal output unit are placed in the cavity after being electrically connected, the signal detection unit is configured to generate a corresponding input signal according to a preset operation performed by a user on the input module, and the signal output unit is connected to an external terminal and configured to output the input signal to the terminal. The fixing module is configured to fix the input device on a preset flat surface.

Abstract: A method of operating a social networking application via an external device includes at an external device having one or more processors and memory storing programs executed by the one or more processors, receiving one or more new message notifications of a social networking application from a social networking terminal; acquiring a playback instruction from a user to play a new message of the social networking application on the external device; transmitting the playback instruction to the social networking terminal; receiving a first voice message corresponding to the new message of the social networking application from the social networking terminal; and playing the first voice message on the external device.

Abstract: The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy.