Abstract: Provided herein is a heavy chain constant region comprising a CH1 domain, a hinge region, a CH2 domain and a CH3 domain, wherein the sequences of said CH1 domain and hinge region derive from the sequences of CH1 domain and hinge region in human IgG2, the sequences of said CH2 domain and CH3 domain derive from the sequences of CH2 domain and CH3 domain in human IgGs; and wherein, said antibody heavy chain constant region has an affinity to human Fc?RIIB equal to or higher than the affinity of human IgG1 to human Fc?RIIB, said antibody heavy chain constant region has an I/A ratio equal to or higher than human IgG1 has. Also provided are antibodies or fusion proteins based on a heavy chain constant region according to the above, wherein the antibody heavy chain constant region significantly enhances agonistic activity of the antibodies or fusion proteins and improves efficacy of the antibodies or fusion proteins in treating diseases like tumors and autoimmune diseases.

Abstract: The disclosure provides a modified EPI sequence for acquiring multi-shot and multi-echo images with interleaved blip-up and blip-down phase encoding; the blip-up and blip-down images are processed by topup in FSL to estimate the inhomogeneous main magnetic field B0 map that causes image distortions; the B0 map is then incorporated into the encoding matrix with a low rank constraint to form a joint reconstruction model; the joint reconstruction model is solved to obtain multiple distortion-free images; and the multiple distortion-free images are matched to dictionary to simultaneous acquire the quantitative T2(=1/R2) and T2*(=1/R2*) maps. In the phantom and in-vivo measurements, the disclosed method rapidly acquires the comparable quantitative images within one hold-breath (for 20 s) to the conventional mapping method, thus providing important practical application value for evaluation of liver damage, iron level and cancer lesion.

Abstract: This application provides a binder composition. The binder composition includes a first fluoropolymer and a second fluoropolymer, where the first fluoropolymer includes polyvinylidene fluoride with a weight-average molecular weight of 5000000-9000000, and a weight-average molecular weight of the second fluoropolymer is not greater than 600000. Featuring good processability, this binder composition, even added in small amounts, can provide electrode plates with great adhesion force and improve the cycling performance of a battery.

Abstract: The present application relates to a binder, a binder composition, a preparation method, a negative electrode slurry, a negative electrode plate, a secondary battery, a battery module, a battery pack and an electrical apparatus. The binder here comprises: an inner core material having a glass transition temperature of ?50° C. to 0° C., and a shell layer material located on at least part of the surface of the inner core material and having a glass transition temperature of 60° C. to 100° C.

Abstract: This application provides a binder composition. The binder composition includes a first fluoropolymer and a second fluoropolymer, where the first fluoropolymer includes polyvinylidene fluoride with a weight-average molecular weight of 1,500,000-5,000,000, and a weight-average molecular weight of the second fluoropolymer does not exceed 600,000. The binder composition has good processability, achieves high adhesion force for the electrode plate when added in small amounts, and improves the cycling performance of the battery.

Abstract: The present invention belongs to the technical field of antibacterial drugs, and discloses a pyrrolylacylpiperidylamine compound and use thereof. The present invention in particular relates to a pyrrolylacylpiperidylamine compound and a pharmaceutically acceptable salt thereof, and use thereof in the preparation of a medicament for resisting infections with bacteria, mycoplasma or chlamydia.

Abstract: This application belongs to the field of optical cables and provides a reinforced protection micro-bunched cable and a manufacturing process thereof. The reinforced protection micro-bunched cable includes reinforced protection micro-bunched tubes; the outer surface of the reinforced protection micro-bunched tube is arranged with bumps and there is a gap between bumps. The thickness of the micro-bunched tube wall at the gap between the bumps is still small, and the bump material is softer than the tube body material. The thickness of the micro-bunched tube wall at the gap between the bumps is still small, which can meet the construction requirements of easiness for stripping; the bump can effectively buffer the external force; further, the added bumps can increase the longitudinal tensile properties of the whole tube, and the tube was not easy to be broken under tension.

Abstract: Proposed are a semiconductor layer including Sn-based perovskite including a chloride-based compound and an iodine-based compound, a thin film transistor including the same, and a manufacturing method thereof. The semiconductor layer includes a perovskite complex, where the perovskite complex includes a Sn-based perovskite and an additive including at least one selected from the group consisting of a first additive and a second additive, the first additive includes at least one selected from the group consisting of a chloride-based compound and an acetate-based compound, and the second additive includes an iodide-based compound (iodide). Thus, a transistor, an environmentally friendly material free of Pb, having high charge mobility and being easily industrialized, can be provided.

Abstract: A unidirectional stranded micro-bundle optical cable and a manufacturing process thereof, where the unidirectional stranded micro-bundle optical cable provided by the present disclosure includes micro-bundle tubes, a reinforcing layer, a water-blocking tape and an outer sheath; a first water-blocking yarn is arranged between the micro-bundle tubes, a tearing rope is arranged in the water-blocking tape, and a reinforcing member is arranged in the outer sheath; the micro-bundle tubes adopt a spiral stranding with a stranding mode of unidirectional stranding and a stranding pitch of 800 mm to 900 mm; the reinforcing layer adopts a spiral stranding with a stranding mode of unidirectional stranding and a stranding pitch of 600 mm to 800 mm; a stranding direction of the micro-bundle tube is opposite to a stranding direction of the reinforcing layer.

Abstract: A magnetic field fresh-keeping apparatus and an air-cooled refrigeration device. The magnetic field fresh-keeping apparatus comprises a drawer container, a drawer, a magnet assembly, and a waterproof structure. The front side of the drawer container has an opening. The drawer is slidably mounted within the drawer container. The magnet assembly comprises a first magnet and a second magnet disposed on opposite sides of the drawer container. The magnet mounting cavity comprises a first mounting cavity for accommodating the first magnet and a second mounting cavity for accommodating the second magnet, and the first mounting cavity and the second mounting cavity are both configured to allow an airflow to pass through so as to cool the first magnet and the second magnet. The waterproof structure is configured to waterproof the magnet assembly.

Abstract: The present application provides a negative electrode plate, comprising a current collector and a negative electrode film layer, wherein the negative electrode film layer comprises a negative electrode active material, a copolymer formed by acrylonitrile and acrylic acid components, and a polyol. Optionally, the negative electrode film layer further comprises a polyether. The cross-linked polymer and polyether described in the present application can reduce the rebound rate of the negative electrode plate during cycling, thereby improving the capacity retention rate of the battery.

Abstract: An embodiment of the present application provide an electrode assembly, a battery cell, a battery, and an electrode assembly manufacturing equipment and method. Among that, the electrode assembly includes a negative electrode plate and a positive electrode plate which form a bending region. The positive electrode plate includes bending portions located in the bending region, the bending portion includes a positive electrode current collecting layer and a positive active substance layer, and at least one side surface of the positive electrode current collecting layer is provided with the positive active substance layer in a thickness direction of the positive electrode plate. At least one positive active substance layer is provided with the barrier layer, at least a part of the barrier layer is intercalated in the positive active substance layer provided with the barrier layer, and coats at least a part of particles in the positive active substance layer.

Abstract: A display module includes a display panel, at least one bonding circuit board, a plurality of chip-on-films, and a plurality of buffer devices. The at least one bonding circuit board each include first differential lines, and a first differential line includes a P-polarity differential sub-line and an N-polarity differential sub-line. An end of a chip-on-film is connected to the first differential line, and the other end of the chip-on-film is connected to the display panel. The buffer devices are arranged on the bonding circuit board, a buffer device is connected to ends, proximate to the chip-on-film, of the P-polarity differential sub-line and the N-polarity differential sub-line, and the buffer device is configured to reduce signal reflection between the first differential line and the chip-on-film.

Abstract: A planetary bevel gear automatic limited slip differential includes five portions that are a main differential, a planetary bevel gear controller, a left drive axle shaft, a right drive axle shaft, and clutches. The planetary bevel gear controller includes an outer control unit and an inner control unit, the outer control unit includes four planetary bevel gears on an outer layer and a bevel gear fixed on a housing, and the inner control unit includes inner planetary bevel gears on an inner side and two bevel gears which have the same parameters and are meshed with the planetary bevel gears. The bevel gears are fixedly connected with outer rings of two overrunning clutches, respectively, and inner rings of the overrunning clutches and the right drive axle shaft are connected together by splines.

Abstract: A system and a method identify an adverse geological body in a tunnel based on hyperspectral technology analysis. The system includes a wall-climbing robot, a controller, and a signal processor, wherein the wall-climbing robot is provided with a plurality of groups of hyperspectral light sources and receivers, and the hyperspectral light sources and the receivers are arranged at intervals; the controller is configured to control the operation of the wall-climbing robot to ensure that the wall-climbing robot moves on a tunnel face according to a set spiral path; and the signal processor communicates with the receivers to receive the acquired spectrum data, draws a mineral distribution map of the tunnel face with the path raveled by the wall-climbing robot as a plane, and identifies an adverse geological body by identifying categories and distribution characteristics of the representative minerals.

Abstract: Provided is a positive electrode slurry, a secondary battery, a battery module, a battery pack and a power consuming device. The positive electrode slurry comprises a positive electrode active substance, a conductive agent and a binder, wherein the binder comprises a polymer A, and the polymer A comprises a structural unit derived from a monomer containing a cyano group, a structural unit derived from a monomer containing an amide group, and a structure unit derived from a monomer containing an ester group. In the present invention, the polymer A is used as the binder of the positive electrode slurry, such that the stability and processability of the positive electrode slurry are improved, and the adhesive force of the positive electrode plate is increased.

Abstract: The present application provides a binder, including a polyvinylidene fluoride having a weight average molar mass of 1.5 million to 5.0 million; optionally, the polyvinylidene fluoride has a weight average molar mass of 1.8 million to 3.2 million.

Abstract: The present application provides a binder, a preparation method therefor, a secondary battery, a battery module, a battery pack, and a power consuming device. The binder comprises a polymer comprising structural units derived from a monomer represented by formula I and structural units derived from a monomer represented by formula II, wherein R1 and R2 are each independently selected from hydrogen or substituted or unsubstituted C1-5 alkyl, R3 is selected from hydrogen or methyl, and R4 is selected from substituted or unsubstituted C1-9 alkyl. The binder can be coated on the surface of the positive electrode active material, which is beneficial to maintain the structural integrity of the positive electrode active material during the cycling of the positive electrode plate, thereby improving the cycling performance of the battery.

Abstract: The present application provides a conductive binder, the conductive binder is formed by reacting polyimide with a conductive agent, and the conductive binder comprises a structural unit represented by formula I containing trifluoromethyl, wherein, R1 and R2 are each independently selected from substituted C6-C25 aromatic groups. For the conductive binder, in the case of a low content of conductive agent and a low amount of conductive binder added, it can greatly reduce the membrane resistance, improve the adhesion of the electrode plate and the cycling capacity retention rate of the battery, and reduce the internal resistance increase rate of the battery in the cycling process.

Abstract: Provided are a binder composition, an electrode, a battery and a power consuming device. The binder composition comprises a fluoropolymer A and a copolymer B, wherein the copolymer B comprises a structural unit derived from a monomer containing a cyano group and a structural unit derived from a monomer containing an ester group. The binder of the present application has a strong bonding force, and the cycling performance of the secondary battery comprising same is excellent.