Abstract: Disclosed herein is a device for detecting nucleic acids, the device comprising a CRISPR-Cas13a-mediated graphene field-effect transistor comprising a source electrode; a drain electrode; a gate electrode; a detection channel; where the channel comprises a CRISPR-Cas13a-mediated graphene layer; where Cas13a is operative to function as an effector protein that targets a specific RNA sequence for cleavage based on a recognition of the RNA sequence by crRNA. Disclosed herein too is a device for detecting nucleic acids, the device comprising a CRISPR-Cas12a-mediated graphene field-effect transistor comprising a source electrode; a drain electrode; a gate electrode; a detection channel; where the channel comprises a CRISPR-Cas12a-mediated graphene layer; where Cas12a is operative to function as an effector protein that targets a specific DNA sequence for cleavage based on a recognition of the DNA sequence by crRNA.

Abstract: A key assembly, which includes a support plate, a flexible circuit board, a buffer block, and a pressing assembly. The support plate has a first surface and a second surface that are opposite to each other. The support plate has an accommodating portion that is recessed from the first surface to a side of the second surface, and the accommodating portion limits an accommodating groove. The flexible circuit board is superposed on the first surface, and the flexible circuit board has a through hole that is correspondingly connected to the accommodating groove. The buffer block is disposed in the accommodating groove, and passes through the through hole. The buffer block has a buffer support surface that protrudes from the flexible circuit board away from one side surface of the support plate. The pressing assembly includes a keycap, a support mechanism, and a connecting rod.

Abstract: A metal-resin composite, a surface treatment method, and a substrate of a printed circuit board (PCB) for high-frequency and high-speed signal transmission comprise a surface-treated metal, and the surface-treated metal includes a nano-scale pore array that is used for filling of a resin and vertically extends from a surface to an interior of a metal, where nano-scale pillars are provided to extend from bottoms to openings of nano-scale pores of the nano-scale pore array. The pillar-in-pore structure makes a resin entering a nano-scale pore have an ultra-high anchoring effect on a resin body outside the nano-scale pore. Therefore, on the premise of not using an additive such as a T liquid or a coupling agent, the present disclosure greatly improves a tensile bonding strength at an interface between a resin body and a metal substrate, and also eliminates a decline in an interfacial bonding strength of a composite.

Abstract: Embodiments of this application provide a keyboard and an electronic device, implementing press buffering and noise reduction. The keyboard includes a support plate and a plurality of keys located on one side of the support plate. Each key includes a key cap and a lifting/lowering assembly, and the lifting/lowering assembly is located between the support plate and the key cap. The lifting/lowering assembly includes a first support and a second support. The first support and the second support each include a first end and a second end. A first buffer structure is further provided on the inner surface of the key cap. When the key cap is pressed, the second end of the first support is in contact with the first buffer structure, and the second end of the second support is in contact with the first buffer structure.

Abstract: A rapid fermentation method for shrimp paste based on combined strain fortification is provided. Cladosporium Z3 and Enterococcus faecalis X1 were deposited in the Chinese typical culture preservation center under preservation numbers CCTCC NO: M 2022487 and CCTCC NO: M 2022486, respectively. Two strains were employed to ferment the small hairy shrimp in two steps, utilizing each strain's properties, which enabled the fermentation capacity to be maximized to increase the fermentation speed and stabilize the quality. In addition, the pollution of miscellaneous bacteria is inhibited by strain-enhanced fermentation.

Abstract: A microspheric ionomer having a cross-linked structure, a preparation method therefor, applications thereof, and a preparation system thereof. The ionomer comprises structure units A represented by formula (1), structure units B represented by formula (2), and a cross-linking structure provided by a cross-linking agent, M being separately selected from H, a metal cation, and a straight chain, a saturated alkyl of branched or ring-shaped C1-C20, R being H or a methyl; and metal cations are introduced to part of structure units A in the ionomer. The ionomer shows an outstanding effect on nucleation of PET, serves as a nucleating agent for PET modification, so as to obtain a corresponding PET composition.

Abstract: A rapid fermentation method for shrimp paste based on combined strain fortification is provided. Cladosporium Z3 and Enterococcus faecalis X1 were deposited in the Chinese typical culture preservation center under preservation numbers CCTCC NO: M 2022487 and CCTCC NO: M 2022486, respectively. Two strains were employed to ferment the small hairy shrimp in two steps, utilizing each strain's properties, which enabled the fermentation capacity to be maximized to increase the fermentation speed and stabilize the quality. In addition, the pollution of miscellaneous bacteria is inhibited by strain-enhanced fermentation.

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: A method for early diagnosis of keratoconus based on multi-modal data considers a mutual relationship between both eyes using four refractive maps for corneas of the both eyes and absolute corneal elevation data, and combines the deep convolutional network method, the traditional support vector machine (SVM) method in machine learning, and the elevation map enhancement method with adjustable best-fit-sphere (BFS) to identify sensitivity and specificity of a focus and balance the sensitivity and specificity. With multi-dimensional comprehensive judgment of a keratoconus morbidity with a patient as a unit, combined with binocular data including both manual selection features and deep network learning from big data, the diagnosis method has higher robustness and accuracy.

Abstract: A method for early diagnosis of keratoconus based on multi-modal data considers a mutual relationship between both eyes using four refractive maps for corneas of the both eyes and absolute corneal elevation data, and combines the deep convolutional network method, the traditional support vector machine (SVM) method in machine learning, and the elevation map enhancement method with adjustable best-fit-sphere (BFS) to identify sensitivity and specificity of a focus and balance the sensitivity and specificity. With multi-dimensional comprehensive judgment of a keratoconus morbidity with a patient as a unit, combined with binocular data including both manual selection features and deep network learning from big data, the diagnosis method has higher robustness and accuracy.

Abstract: An automatic traction device for a lower limb fracture osteosynthesis includes a chassis structure, a lower leg supporting structure and an upper leg supporting structure connected two by two. The automatic traction device further includes a tibia distal position adjusting device, for adjusting a position and an angle of a distal end of a tibia, on the lower leg supporting structure and close to the first end portion of the lower leg supporting structure; and a tibia proximal position adjusting device, for adjusting a position and an angle of a proximal end of a tibia, on the lower leg supporting structure and close to the second end portion of the lower leg supporting structure.

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: An automatic traction device for a lower limb fracture osteosynthesis includes a chassis structure, a lower leg supporting structure and an upper leg supporting structure connected two by two. The automatic traction device further includes a tibia distal position adjusting device, for adjusting a position and an angle of a distal end of a tibia, on the lower leg supporting structure and close to the first end portion of the lower leg supporting structure; and a tibia proximal position adjusting device, for adjusting a position and an angle of a proximal end of a tibia, on the lower leg supporting structure and close to the second end portion of the lower leg supporting structure.

Abstract: The present disclosure relates to systems and methods for personalized recommendation. The systems may perform the methods to detect an application executing on the user terminal. The systems may perform the methods to communicate with the application with respect to a service request sent by the user via the user terminal. The systems may perform the methods to obtain one or more current context-related features and one or more current-user-related features with respect to the user, and a plurality of candidate recommendation items. The systems may perform the methods to select a target recommendation item from the plurality of candidate recommendation items based on the one or more current context-related features and the one or more current user-related features, using a trained recommendation model, and provide the target recommendation item to the application to generate a presentation, on a display of the user terminal of the user.

Abstract: Disclosed are 4-amino-2-butenamides of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.

Abstract: The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.