Abstract: A method of converting a poorly water soluble crystalline compound to an amorphous compound and a method of increasing the solubility of a poorly water soluble crystalline compound in biorelevant fluid at pH 6.5 is disclosed. The method includes dissolving the compound and a polymer in a solvent to form a solution, the polymer being present in the solution in an amount such that after electrospraying the solution the compound is in an amorphous form, electrospraying the solution using an electrospray system, the electrospraying forming nanoparticles, collecting the nanoparticles on a substrate, and removing the nanoparticles in the form of a powder.

Abstract: Methods of electrospraying particles are disclosed that include electrospraying a liquid spray composition from the nozzle, the liquid spray composition including a liquid and a compound that exhibits a melting point and a crystallization temperature, and at least one of exposing particles formed from the liquid spray composition to a temperature modified environment, exposing particles formed from the liquid spray composition to an organic solvent, and collecting particles formed from the liquid spray composition on at least one of a temperature modified collector, a liquid collector, a variable topography collector, and a dry ice collector.