Patents by Inventor Huilin L. Qi

Huilin L. Qi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
    Patent number: 6013267
    Abstract: The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: January 11, 2000
    Assignees: North American Vaccine, Inc., The Rockefeller University
    Inventors: Milan S. Blake, Joseph Y. Tai, Huilin L. Qi, Shu-Mei Liang, Lucjan J.J. Hronowski, Jeffrey K. Pullen
  • Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
    Patent number: 5879686
    Abstract: The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: March 9, 1999
    Assignees: North American Vaccine, Inc., The Rockefeller University
    Inventors: Milan S. Blake, Joseph Y. Tai, Huilin L. Qi, Shu-Mei Liang, Lucjan J. J. Hronowski, Jeffrey K. Pullen
  • Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
    Patent number: 5747287
    Abstract: The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: May 5, 1998
    Assignees: North American Vaccine, Inc., The Rockefeller University
    Inventors: Milan S. Blake, Joseph Y. Tai, Huilin L. Qi, Shu-Mei Liang, Lucjan J. J. Hronowski, Jeffrey K. Pullen
  • Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
    Patent number: 5439808
    Abstract: The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins yard fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: August 8, 1995
    Assignees: North American Vaccine, Inc., The Rockefeller University
    Inventors: Milan S. Blake, Joseph Y. Tai, Huilin L. Qi, Shu-Mei Liang, Lucjan J. J. Hronowski, Jeffrey K. Pullen